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- Dåderman, Anna Maria, 1953-, et al.
(författare)
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Violent behavior, impulsive decision-making, and anterograde amnesia while intoxicated with Flunitrazepam and alcohol or other drugs : A case study in forensic psychiatric patients
- 2002
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Ingår i: The journal of the American Academy of Psychiatry and the Law. - Bloomfield, CT, USA. - 1093-6793 .- 1943-3662. ; 30:2, s. 238-251
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Tidskriftsartikel (refereegranskat)abstract
- It is known that many male juvenile delinquents commit violent crimes while intoxicated with flunitrazepam (FZ), often in combination with alcohol or other drugs. We have also noted the combined abuse of FZ with, for example, alcohol in male forensic psychiatric patients. Our objective was to study violent behavior, impulsive decision making, and amnesia in male forensic psychiatric patients who were intoxicated predominantly with FZ, to increase knowledge of the abuse of FZ in vulnerable subjects. We studied five forensic psychiatric patients, all of whom were assessed in 1998. All of the subjects reported earlier reactions to FZ, including hostility and anterograde amnesia. At the time of their crimes they were all intoxicated with FZ, often in combination with alcohol or other drugs, such as amphetamine or cannabis. In contrast to their behavior based on their ordinary psychological characteristics, their crimes were extremely violent, and the subjects lacked both the ability to think clearly and to have empathy with their victims. Our observations support the view that FZ abuse can lead to serious violent behavior in subjects characterized by vulnerable personality traits, and that this effect is confounded by the concurrent use of alcohol or other drugs. It is evident that FZ causes anterograde amnesia. Previous research and the results presented herein allow us to draw the following conclusion: on the basis of the neuropsychopharmacologic properties of FZ, legal decisions, such as declaring FZ an illegal drug, are needed in countries where it is now legal.
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- Jacobsson, Josefin A., et al.
(författare)
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Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly
- 2011
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:5, s. e20158-
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Tidskriftsartikel (refereegranskat)abstract
- Background: The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals' height, but offers no insight into the regional body fat composition or distribution. Objective: To examine whether the FTO gene is associated with overweight and body composition-related phenotypes rather than BMI, we measured waist circumference, total fat mass, trunk fat mass, leg fat mass, visceral and subcutaneous adipose tissue, and daily energy intake in 985 humans (493 women) at the age of 70 years. In total, 733 SNPs located in the FTO gene were genotyped in order to examine whether rs9939609 alone or the other SNPs, or their combinations, are linked to obesity-related measures in elderly humans. Design: Cross-sectional analysis of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Results: Neither a single SNP, such as rs9939609, nor a SNP combination was significantly linked to overweight, body composition-related measures, or daily energy intake in elderly humans. Of note, these observations hold both among men and women. Conclusions: Due to the diversity of measurements included in the study, our findings strengthen the view that the effect of FTO on body composition appears to be less profound in later life compared to younger ages and that this is seemingly independent of gender.
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- Nilsson, Magnus, et al.
(författare)
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A 9-band WCDMA/EDGE transceiver supporting HSPA evolution
- 2011
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Ingår i: [Host publication title missing]. - 0193-6530. ; , s. 366-368
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Konferensbidrag (refereegranskat)abstract
- The future of cellular radio ICs lies in the integration of an ever-increasing number of bands and channel bandwidths. This paper presents a transceiver together with the associated discrete front-end components. The transceiver supports 4 EDGE bands and 9 WCDMA bands (l-VI and Vlll-X), while the radio can be configured to simultaneously support the 4 EDGE bands and up to 5 WCDMA bands: 3 high bands (HB) and 2 low bands (LB). The RX is a SAW-less homodyne composed of a main RX and a diversity RX. To reduce package complexity with so many bands, we chose to minimize the number of ports by using single-ended RF interfaces for both RX and TX. This saves seve ral package pins, but requires careful attention to grounding. The main RX has 8 LNA ports and the diversity RX has 5, with some LNAs supporting multiple bands. On the TX side, 2 ports are used for all EDGE bands and 4 for the WCDMA bands.
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| 5. |
- Roland, P, et al.
(författare)
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A database generator for human brain imaging
- 2001
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Ingår i: TINS - Trends in Neurosciences. - 0166-2236 .- 1878-108X. ; 24:10, s. 562-564
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Tidskriftsartikel (refereegranskat)abstract
- Sharing scientific data containing complex information requires new concepts and new technology. NEUROGENERATOR is a database generator for the neuroimaging community. A database generator is a database that generates new databases. The scientists submit raw PET and fMRI data to NEUROGENERATOR, which then processes the data in a uniform way to create databases of homogenous data suitable for data sharing, met-analysis and modelling the human brain at the systems level. These databases are then distributed to the scientists.
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| 8. |
- Almqvist, Nils, et al.
(författare)
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Imaging human erythrocyte spectrin with atomic force microscopy
- 1994
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Ingår i: Micron. - : Elsevier BV. - 0968-4328 .- 1878-4291. ; 25:3, s. 227-232
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Tidskriftsartikel (refereegranskat)abstract
- Isolated spectrin covalently attached to a surface in a liquid environment as well as dried on mica has been studied with a contact-mode atomic force microscope. Both pyramidal and conical-type cantilever tip facets were used in the AFM. Our images show structures and give dimensions that correlate well with previous structural studies using transmission electron microscopy.
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| 10. |
- Anistratov, Pavel, 1990-
(författare)
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Computation of Autonomous Safety Maneuvers Using Segmentation and Optimization
- 2019
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis studies motion planning for future autonomous vehicles with main focus on passenger cars. By having automatic steering and braking together with information about the environment, such as other participants in the traffic or obstacles, it would be possible to perform autonomous maneuvers while taking limitations of the vehicle and road–tire interaction into account. Motion planning is performed to find such maneuvers that bring the vehicle from the current state to a desired future state, here by formulating the motion-planning problem as an optimal control problem. There are a number of challenges for such an approach to motion planning; some of them are how to formulate the criterion in the motion planning (objective function in the corresponding optimal control problem), and how to make the solution of motion-planning problems efficient to be useful in online applications. These challenges are addressed in this thesis.As a criterion for motion-planning problems of passenger vehicles on doublelane roads, it is investigated to use a lane-deviation penalty function to capture the observation that it is dangerous to drive in the opposing lane, but safe to drive in the original lane after the obstacle. The penalty function is augmented with certain additional terms to address also the recovery behavior of the vehicle. The resulting formulation is shown to provide efficient and steady maneuvers and gives a lower time in the opposing lane compared to other objective functions. Under varying parameters of the scenario formulation, the resulting maneuvers are changing in a way that exhibits structured characteristics.As an approach to improve efficiency of computations for the motion-planning problem, it is investigated to segment motion planning of the full maneuver into several smaller maneuvers. A way to extract segments is considered from a vehicle dynamics point of view, and it is based on extrema of the vehicle orientation and the yaw rate. The segmentation points determined using this approach are observed to allow efficient splitting of the optimal control problem for the full maneuver into subproblems.Having a method to segment maneuvers, this thesis further studies methods to allow parallel computation of these maneuvers. One investigated method is based on Lagrange relaxation and duality decomposition. Smaller subproblems are formulated, which are governed by solving a low-complexity coordination problem. Lagrangian relaxation is performed on a subset of the dynamic constraints at the segmentation points, while the remaining variables are predicted. The prediction is possible because of the observed structured characteristics resulting from the used lane-deviation penalty function. An alternative approach is based on adoption of the alternating augmented Lagrangian method. Augmentation of the Lagrangian allows to apply relaxation for all dynamic constraints at the segmentation points, and the alternating approach makes it possible to decompose the full problem into subproblems and coordinating their solutions by analytically solving an overall coordination problem. The presented decomposition methods allow computation of maneuvers with high correspondence and lower computational times compared to the results obtained for solving the full maneuver in one step.
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