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Sökning: WFRF:(Fredriksson Per)

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2.
  • Bertilsson, Johan, et al. (författare)
  • Stress Levels Escalate When Repeatedly Performing Tasks Involving Threats
  • 2019
  • Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 10, s. 1562-1562
  • Tidskriftsartikel (refereegranskat)abstract
    • Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically affect police officers in terms of heart rate and pupil diameter properties. Psychological stress is commonly assessed by monitoring the changes in these biomarkers. Heart rate and pupil diameter was measured in 12 male police officers when performing a sequence of four stressful tasks, each lasting between 20 and 130 s. The participants were first placed in a dimly illuminated anteroom before allowed to enter a brightly lit room where a scenario was played out. After each task was performed, the participants returned to the anteroom for about 30 s before performing the next sequential task. Performing a repeated sequence of stressful tasks caused a significant increase in heart rate (p = 0.005). The heart rate started to increase already before entering the scenario room and was significantly larger just after starting the task than just before starting the task (p < 0.001). This pattern was more marked during the first tasks (p < 0.001). Issuance of a verbal "abort" command which terminated the tasks led to a significant increase of heart rate (p = 0.002), especially when performing the first tasks (p = 0.002). The pupil diameter changed significantly during the repeated tasks during all phases but in a complex pattern where the pupil diameter reached a minimum during task 2 followed by an increase during tasks 3 and 4 (p ≤ 0.020). During the initial tasks, the pupil size (p = 0.014) increased significantly. The results suggest that being repeatedly exposed to stressful tasks can produce in itself an escalation of psychological stress, this even prior to being exposed to the task. However, the characteristics of both the heart rate and pupil diameter were complex, thus, the findings highlight the importance of studying the effects and dynamics of different stress-generating factors. Monitoring heart rate was found useful to screen for stress responses, and thus, to be a vehicle for indication if and when rotation of deployed personnel is necessary to avoid sustained high stress exposures.
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3.
  • Bertilsson, Johan, et al. (författare)
  • Towards systematic and objective evaluation of police officer performance in stressful situations
  • 2020
  • Ingår i: Police Practice and Research. - : Informa UK Limited. - 1561-4263 .- 1477-271X. ; 21:6, s. 655-669
  • Tidskriftsartikel (refereegranskat)abstract
    • To ensure a continuous high standard of police units, it is critical to recruit people who perform well in stressful situations. Today, this selection process includes performing a large series of tests, which still may not objectively reveal a person’s capacity to handle a life-threatening situation when subjected to high levels of stress. To obtain more systematic and objective data, 12 police officers were exposed to six scenarios with varying levels of threat while their heart rate and pupil size were monitored. The scenarios were filmed and six expert evaluators assessed the performance of the police officers according to seven predefined criteria. Four of the scenarios included addressing a moderate threat level task and the scenarios were executed in a rapid sequence. Two further scenarios included a familiar firearm drill performed during high and low threat situations. The results showed that there was a large agreement between the experts in how they judged the performance of the police officers (p < 0.001). Performance increased significantly over tasks in four of the seven evaluation criteria (p ≤ 0.037). There was also a significant effect of pupil size (p = 0.004), but not heart rate, when comparing the different sequential scenarios. Moreover, a high level of threat considerably impaired the motor performance of the police officers during the firearms drill (p = 0.002). Finally, the pupil seemed to systematically dilate more when a threat appeared immediately than with a delay in the scenarios (p = 0.007). We conclude that systematic and quantitative judgments from experts provide valuable and reliable information about the performance of participants in realistic and stressful policing scenarios. Furthermore, objective physiological measures of heart rate and pupil size may help to explain and understand why performance sometimes deteriorates.
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4.
  • Edin, Per-Anders, et al. (författare)
  • The effect of trade on earnings - evidence from Swedish micro data
  • 2004
  • Ingår i: Oxford Economic Papers. - : Oxford University Press (OUP). - 1464-3812 .- 0030-7653. ; 56:2, s. 231-241
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Using a large longitudinal data set, we study the effects of increased trade on earnings in the Swedish labor market. Earnings respond significantly to changes in industry sales, whether generated by domestic market forces or international trade: Swedish exports (imports) raise (lower) annual earnings, but changes in trade affect earnings just as any other shift in market conditions. We also examine whether the effects of trade vary by skill. We do not find systematic differences in the effects of trade across the skill distribution.
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5.
  • Edin, Per-Anders, et al. (författare)
  • Trade, earnings and mobility : Swedish evidence
  • 2000
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Using a large longitudinal data set, we study the effects of increased trade on earnings and mobility in the Swedish labor market in the late 1980s and early 1990s. Earnings respond significantly to changes in industry sales, whether generated by domestic market forces or international trade: Swedish exports (imports) raise (lower) annual earnings, but changes in trade affect earnings just as any other shift in market conditions. In general, the wage effects are small; the prime response to changes in the product market appears to be variations in employment. We also examine whether trade has differential effects across skill groups. However, we do not find systematic differences in the effects of trade across the earnings distribution.
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8.
  • Fredriksson, Per, et al. (författare)
  • Wedge indentation of thin films modelled by strain gradient plasticity
  • 2008
  • Ingår i: International Journal of Solids and Structures. - : Elsevier BV. - 0020-7683 .- 1879-2146. ; 45:21, s. 5556-5566
  • Tidskriftsartikel (refereegranskat)abstract
    • A plane strain study of wedge indentation of a thin film on a substrate is performed. The film is modelled with the strain gradient plasticity theory by Gudmundson [Gudmundson, P., 2004. A unified treatment of strain gradient plasticity. journal of the Mechanics and Physics of Solids 52, 1379-1406] and analysed using finite element simulations. Several trends that have been experimentally observed elsewhere are captured in the predictions of the mechanical behaviour of the thin film. Such trends include increased hardness at shallow depths due to gradient effects as well as increased hardness at larger depths due to the influence of the substrate. In between, a plateau is found which is observed to scale linearly with the material length scale parameter. It is shown that the degree of hardening of the material has a strong influence on the substrate effect, where a high hardening modulus gives a larger impact on this effect. Furthermore, pile-up deformation dominated by plasticity at small values of the internal length scale parameter is turned into sink-in deformation where plasticity is suppressed for larger values of the length scale parameter. Finally, it is demonstrated that the effect of substrate compliance has a significant effect on the hardness predictions if the effective stiffness of the substrate is of the same order as the stiffness of the film.
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9.
  • Lindblom, Per, 1974, et al. (författare)
  • Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
  • 2003
  • Ingår i: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 17:15, s. 1835-40
  • Tidskriftsartikel (refereegranskat)abstract
    • Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
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10.
  • Niméus, Emma, et al. (författare)
  • Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy
  • 2008
  • Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 10:2
  • Tidskriftsartikel (refereegranskat)abstract
    • IntroductionSome patients with breast cancer develop local recurrence after breast-conservation surgery despite postoperative radiotherapy, whereas others remain free of local recurrence even in the absence of radiotherapy. As clinical parameters are insufficient for identifying these two groups of patients, we investigated whether gene expression profiling would add further information.MethodsWe performed gene expression analysis (oligonucleotide arrays, 26,824 reporters) on 143 patients with lymph node-negative disease and tumor-free margins. A support vector machine was employed to build classifiers using leave-one-out cross-validation.ResultsWithin the estrogen receptor-positive (ER+) subgroup, the gene expression profile clearly distinguished patients with local recurrence after radiotherapy (n = 20) from those without local recurrence (n = 80 with or without radiotherapy). The receiver operating characteristic (ROC) area was 0.91, and 5,237 of 26,824 reporters had a P value of less than 0.001 (false discovery rate = 0.005). This gene expression profile provides substantially added value to conventional clinical markers (for example, age, histological grade, and tumor size) in predicting local recurrence despite radiotherapy. Within the ER- subgroup, a weaker, but still significant, signal was found (ROC area = 0.74). The ROC area for distinguishing patients who develop local recurrence from those who remain local recurrence-free in the absence of radiotherapy was 0.66 (combined ER+/ER-).ConclusionA highly distinct gene expression profile for patients developing local recurrence after breast-conservation surgery despite radiotherapy has been identified. If verified in further studies, this profile might be a most important tool in the decision making for surgery and adjuvant therapy.
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