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- Iliadis, Stavros I., 1983-, et al.
(författare)
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Psychometric properties and concurrent validity of the Transgender Congruence Scale (TCS) in the Swedish setting
- 2020
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The Transgender Congruence Scale (TCS) is a non-binary tool used in Sweden for gender dysphoria (GD) assessment; however, its Swedish version has not been validated. To investigate the psychometric properties of the TCS, its capacity to distinguish individuals with GD and its concurrent validity compared to other scales. Patients with GD (n=135) and controls (n=443) filled in a questionnaire containing sociodemographic questions, the TCS, the Utrecht Gender Dysphoria Scale (UGDS), and the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults (GIDYQ-AA). TCS had good discriminatory validity and internal consistency. Patients with GD, stratified by birth-assigned sex, had lower TCS scores compared to controls. Confirmatory factor analysis (CFA) supported the two-factor model of the TCS. Multiple-group CFA suggested measurement invariance between birth-assigned sexes and configural invariance between patients with GD and controls. Area under the ROC curve for birth-assigned males was 0.991 and for females 0.994. A TCS mean value of three provided sensitivity 94.3% and 95.1% as well as specificity 98.6% and 98% for aM and aF, respectively. The TCS was significantly correlated to UGDS and GIDYQ-AA. The TCS may be a valuable tool in the clinical assessment of individuals with GD.
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- Smith, Michael, et al.
(författare)
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A field investigation on associations between environmental noise and adolescent physiological sleep: An Equal-Life study
- 2023
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Ingår i: 14th ICBEN Congress on Noise as a Public Health Problem.
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Konferensbidrag (refereegranskat)abstract
- There is a need for field studies incorporating objective measures of both noise and sleep. Within the EU project Equal-Life we performed an in-depth field study to investigate associations between nocturnal noise exposure and physiological sleep. Participants (n=109; 68 female) were adolescents/young adults (18-19 years) recruited from within the longitudinal birth cohort STARS, around Gothenburg, Sweden. The noise exposure and sleep of each subject was investigated for four consecutive nights, from Tuesday night to Saturday morning. Outdoor noise was measured with sound level meters mounted outside bedroom windows. Indoor noise measurements and audio recordings were made in the bedrooms. Sleep was measured with a headband (DREEM3) incorporating dry EEG electrodes. Questionnaires were administered every evening and morning, and included items on daytime activities, sleepiness (Karolinska Sleepiness Scale), sleep quality, sleep disturbance by noise, and the bedroom environment. Outdoor noise measurements were obtained for 465 days and nights. Nighttime levels ranged from 35.8 to 73.7 dB Lnight (mean±SD 47.6±5.5 dB Lnight). Twenty-four hour levels ranged from 39.5 to 69.1 dB LAEq,24h (mean±SD 51.3±5.4 dB LAEq,24h). Data analysis is ongoing, and results will be presented at the congress. We will determine associations between average noise levels (Lnight, and LAEq during the EEG-derived sleep period) and sleep structure. We will also determine acute effects of discrete noise events on sleep fragmentation including noise-induced awakenings and changes of sleep stage.
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- van Doorn, Leni, et al.
(författare)
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Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel
- 2021
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:15
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary This study investigated the correlation between scalp cooling used to prevent chemotherapy-induced alopecia and the pharmacokinetics of paclitaxel in female cancer patients with a solid tumor. In a prospective cohort study, 14 patients who were treated with weekly paclitaxel and scalp cooling were able to undergo pharmacokinetic sampling of paclitaxel during one cycle of treatment. In comparison to a control cohort of 24 patients treated with weekly paclitaxel without scalp cooling, our data showed that scalp cooling used concomitantly with one course of paclitaxel did not reduce or increase the clearance of paclitaxel. Therefore, it is unlikely that scalp cooling influences paclitaxel efficacy or toxicity. Finally, despite scalp cooling, half of the patients in our study developed a form of hair loss. Importantly, neither an association with difference in paclitaxel clearance nor change in hair loss was found. Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs. However, the effects of this prolonged scalp cooling on the pharmacokinetics of chemotherapy have never been investigated. In this study, we compared the pharmacokinetics of the widely used chemotherapeutic agent paclitaxel (weekly dose of 80-100 mg/m(2)) in female patients with solid tumors using concomitant scalp cooling (n = 14) or not (n = 24). Blood samples were collected in all patients for pharmacokinetic analyses up to 6 h after one course of paclitaxel administration. The primary endpoint was the clearance (L/h) of paclitaxel. Paclitaxel clearance-expressed as relative difference in geometric means-was 6.8% (90% CI: -16.7% to 4.4%) lower when paclitaxel was administered with concomitant scalp cooling versus paclitaxel infusions without scalp cooling. Within the subgroup of patients using scalp cooling, paclitaxel clearance was not statistically significantly different between patients with CIA (alopecia grade 1 or 2) and those without CIA. Hence, scalp cooling did not negatively influence the clearance of paclitaxel treatment.
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- Wassénius, Emmy, et al.
(författare)
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Creative destruction in academia : a time to reimagine practices in alignment with sustainability values
- 2023
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Ingår i: Sustainability Science. - : Springer Nature. - 1862-4065 .- 1862-4057. ; 18:6, s. 2769-2775
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Tidskriftsartikel (refereegranskat)abstract
- Academia has experienced acceleration and expansion in parallel with the Great Acceleration, which has shaped the Anthropocene. Among other pressures, the expectation to be internationally mobile conflicts with many values held by sustainability scholars and results in disillusionment. The changes in the academic system can be seen through the framework of the adaptive cycle, which can help us understand historical parallels and shape the system to better align with sustainability values in future. We hope this piece can contribute to the discussion of the next steps forward to reimagine academia.
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