| 1. |
- Skibniewski, Mikolaj, et al.
(författare)
-
Long-term antithrombotic therapy after coronary artery bypass grafting in patients with preoperative atrial fibrillation. A nationwide observational study from the SWEDEHEART registry
- 2023
-
Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 257, s. 69-77
-
Tidskriftsartikel (refereegranskat)abstract
- Aims To provide data guiding long-term antithrombotic therapy after coronar y arter y by-pass grafting (CABG) in patients with preoperative atrial fibrillation (AF). Methods and results From the SWEDEHEART registry, we included all patients, between January 2006 and September 2016, with preoperative AF and CHA2DS2-VASC score >2, undergoing CABG. Based on dispensed prescriptions 12 to 18 months after CABG, patients were divided in 3 groups: use of platelet inhibitors (PI) only, oral anticoagulant (OAC) only or a combination of OAC + PI. Outcomes were: Major adverse cardiac and cerebrovascular events (MACCE, [all-cause death, myocardial infarction, or stroke]), net adverse clinical events (NACE, [MACCE or bleeding]) and the individual components of NACE. Inverse probability of treatment weighting was used to adjust for the non-randomized study design. Among 2,564 patients, 1,040 (41%) were treated with PI alone, 1,064 (41%) with OAC alone, and 460 (18%) with PI + OAC. Treatment with PI alone was associated with higher risk for MACCE (adjusted HR 1.43, 95% CI 1.09-1.88), driven by higher risk for stroke and MI, compared with OAC alone. Treatment with PI + OAC, was associated with higher risk for NACE (adjusted HR 1.40, 95% CI 1.06-1.85), driven by higher risk for bleeds, compared with OAC alone. Conclusion In this real-world observational study, a high proportion of patients with AF, undergoing CABG, did not receive a long-term OAC therapy. Treatment with OAC alone was associated with a net clinical benefit, compared with PI alone or PI + OAC. (Am Heart J 2023;257:69-77.)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Friberg Heppin, Karin, 1963, et al.
(författare)
-
Using FrameNet in Communicative Language Teaching
- 2012
-
Ingår i: Proceedings of the XV EURALEX International Congress in Oslo, Norway. - 9788230322284
-
Konferensbidrag (refereegranskat)abstract
- This article describes how a lexical database such as FrameNet in its different language versions can be used for communicative language teaching, an approach which focuses on communicative rather than grammatical competence. Using the semantic frames of FrameNet to illustrate situations on which to base teaching can bring about a natural flow in the organisation of teaching materials, in syllabus construction, and in the planning of individual lessons. FrameNet can also support language students in learning to communicate in different situations. The frames can guide them in choosing lexical units and sentence patterns.
|
|
| 5. |
|
|
| 6. |
- Löfqvist, Chatarina, 1964, et al.
(författare)
-
A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants
- 2009
-
Ingår i: Pediatric Research. - 1530-0447 .- 0031-3998. ; 65:5, s. 574-9
-
Tidskriftsartikel (refereegranskat)abstract
- In preterm infants, low levels of insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of i.v. administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 d chronological age, an i.v. 3 h infusion of rhIGF-I/rhIGFBP-3 was administered followed by serial measurements of IGF-I and IGFBP-3. Infants were evaluated for physiologic safety measurements. The individual dose of rhIGF-I ranged from 1 to 12 microg/kg. The study was conducted at Queen Silvia Children's Hospital, Gothenburg, Sweden, between January and November 2007. Five patients (3 F) with mean (range) post menstrual age 27 wk (26-29) and birth weight 1022 g (810-1310) participated. IGF-I and IGFBP-3 levels before infusion were median (range) 18 (12-28) and 771 (651-1047) ng/mL, respectively. Immediately after study drug infusion, serum IGF-I and IGFBP-3 levels were 38 (25-59) and 838 (754-1182) ng/mL, respectively. Median (range) half-life for IGF-I and IGFBP-3 was 0.79 (0.59-1.42) and 0.87 (0.85-0.94) hours, respectively. Blood glucose, insulin, sodium, potassium, and physiologic safety measures were within normal ranges. The rhIGF-I/rhIGFBP-3 equimolar proportion was effective in increasing serum IGF-I levels and administration under these study conditions was safe and well tolerated.
|
|
| 7. |
- Masko, Jonas, et al.
(författare)
-
Software tools for automatic music performance
- 2014
-
Ingår i: 1st international workshop on computer and robotic Systems for Automatic Music Performance (SAMP14). - Venice.
-
Konferensbidrag (refereegranskat)abstract
- Two new computer programs are presented for the purpose of facilitating new research in music performance modeling. Director Musices (DM) is a new an implementation of the user interface for the KTH rule system. It includes a new integrated player and several other improvements. The automatic sampler facilitates the sampling of a MIDI-controlled instrument, such as the Disklavier piano from Yamaha. Both programs are open source, cross-platform written in Java and in the case of DM including also different lisp dialects.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Abera, Asmamaw, et al.
(författare)
-
Air Quality in Africa : Public Health Implications
- 2021
-
Ingår i: Annual review of public health. - : Annual Reviews. - 0163-7525 .- 1545-2093. ; 42, s. 193-210
-
Tidskriftsartikel (refereegranskat)abstract
- This review highlights the importance of air quality in the African urban development process. We address connections between air pollution and (a) rapid urbanization, (b) social problems, (c) health impacts, (d) climate change, (e) policies, and ( f ) new innovations. We acknowledge that air pollution levels in Africa can be extremely high and a serious health threat. The toxic content of the pollution could relate to region-specific sources such as low standards for vehicles and fuels, cooking with solid fuels, and burning household waste. We implore the pursuit of interdisciplinary research to create new approaches with relevant stakeholders. Moreover, successful air pollution research must regard conflicts, tensions, and synergies inherent to development processes in African municipalities, regions, and countries. This includes global relationships regarding climate change, trade, urban planning, and transportation. Incorporating aspects of local political situations (e.g., democracy) can also enhance greater political accountability and awareness about air pollution. Expected final online publication date for the Annual Review of Public Health, Volume 42 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
|
|
