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- Fristedt, R., et al.
(författare)
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PSB33 sustains photosystem II D1 protein under fluctuating light conditions
- 2017
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Ingår i: Journal of Experimental Botany. - : Oxford University Press (OUP). - 0022-0957 .- 1460-2431. ; 68:15, s. 4281-4293
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Tidskriftsartikel (refereegranskat)abstract
- On Earth, solar irradiance varies as the sun rises and sets over the horizon, and sunlight is thus in constant fluctuation, following a slow dark-low-high-low-dark curve. Optimal plant growth and development are dependent on the capacity of plants to acclimate and regulate photosynthesis in response to these changes of light. Little is known of regulative processes for photosynthesis during nocturnal events. The nucleus-encoded plant lineage-specific protein PSB33 has been described as stabilizing the photosystem II complex, especially under light stress conditions, and plants lacking PSB33 have a dysfunctional state transition. To clarify the localization and function of this protein, we used phenomic, biochemical and proteomics approaches in the model plant Arabidopsis. We report that PSB33 is predominantly located in non-appressed thylakoid regions and dynamically associates with a thylakoid protein complex in a light-dependent manner. Moreover, plants lacking PSB33 show an accelerated D1 protein degradation in nocturnal periods, and show severely stunted growth when challenged with fluctuating light. We further show that the function of PSB33 precedes the STN7 kinase to regulate or balance the excitation energy of photosystems I and II in fluctuating light conditions.
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| 2. |
- Engstrand, J., et al.
(författare)
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Liver resection and ablation for squamous cell carcinoma liver metastases
- 2021
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Ingår i: BJS Open. - Oxford, United Kingdom : Oxford University Press. - 2474-9842. ; 5:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS).METHOD: Members of the European-African Hepato-Pancreato-Biliary Association were invited to include all consecutive patients undergoing liver resection/ablation for SCC liver metastases between 2002 and 2019. Patient, tumour and perioperative characteristics were analysed with regard to RFS and OS.RESULTS: Among the 102 patients included from 24 European centres, 56 patients had anal cancer, and 46 patients had SCC from other origin. RFS in patients with anal cancer and non-anal cancer was 16 and 9 months, respectively (P = 0.134). A positive resection margin significantly influenced RFS for both anal cancer and non-anal cancer liver metastases (hazard ratio 6.82, 95 per cent c.i. 2.40 to 19.35, for the entire cohort). Median survival duration and 5-year OS rate among patients with anal cancer and non-anal cancer were 50 months and 45 per cent and 21 months and 25 per cent, respectively. For the entire cohort, only non-radical resection was associated with worse overall survival (hazard ratio 3.21, 95 per cent c.i. 1.24 to 8.30).CONCLUSION: Liver resection/ablation of liver metastases from SCC can result in long-term survival. Survival was superior in treated patients with liver metastases from anal versus non-anal cancer. A negative resection margin is paramount for acceptable outcome.
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| 4. |
- Gmoser, Rebecca, 1990-, et al.
(författare)
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From stale bread and brewers spent grain to a new food source using edible filamentous fungi
- 2020
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Ingår i: Bioengineered Bugs. - : Informa UK Limited. - 2165-5979 .- 2165-5987. ; 11:1, s. 582-598
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Tidskriftsartikel (refereegranskat)abstract
- By-products from the food sector with a high load of organic matter present both a waste-handling problem related to expenses and to the environment, yet also an opportunity. This study aims to increase the value of stale bread and brewers spent grain (BSG) by re-introducing these residues to the food production chain by converting them to new protein-enriched products using the edible filamentous fungi Neurospora intermedia and Rhizopusoryzae. After 6 days of solid state fermentation (at 35°C, with a95% relative humidity and moisture content of 40% in the substrate) on stale bread, a nutrient-rich fungal-fermented product was produced. The total protein content, as analyzed by total amino acids, increased from 16.5% in stale sourdough bread to 21.1% (on dry weight basis) in the final product with an improved relative ratio of essential amino acids. An increase in dietary fiber, minerals (Cu, Fe, Zn) and vitamin E, as well as an addition of vitamin D2 (0.89 µg/g dry weight sample) was obtained compared with untreated stale bread. Furthermore, addition of BSG to the sourdough bread with the aim to improve textural changes after fermentation showed promising outcomes. Cultivation of N. intermedia or R. oryzae on stale sourdough bread mixed with 6.5% or 11.8% BSG, respectively, resulted in fungal-fermented products with similar textural properties to a commercial soybean burger. Bioconversion of stale bread and BSG by fungal solid state fermentation to produce a nutrient-enriched food product was confirmed to be a successful way to minimize food waste and protein shortage.
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| 7. |
- Rosenqvist, L., et al.
(författare)
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3D Modeling of Geomagnetically Induced Currents in Sweden-Validation and Extreme Event Analysis
- 2022
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Ingår i: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 20:3
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Tidskriftsartikel (refereegranskat)abstract
- Rosenqvist and Hall (2019), developed a proof-of-concept modeling capability that incorporates a detailed 3D structure of Earth's electrical conductivity in a geomagnetically induced current estimation procedure (GIC-SMAP). The model was verified based on GIC measurements in northern Sweden. The study showed that southern Sweden is exposed to stronger electric fields due to a combined effect of low crustal conductivity and the influence of the surrounding coast. This study aims at further verifying the model in this region. GIC measurements on a power line at the west coast of southern Sweden are utilized. The location of the transmission line was selected to include coast effects at the ocean-land interface to investigate the importance of using 3D induction modeling methods. The model is used to quantify the hazard of severe GICs in this particular transmission line by using historic recordings of strong geomagnetic disturbances. To quantify a worst-case scenario GICs are calculated from modeled magnetic disturbances by the Space Weather Modeling Framework based on estimates for an idealized extreme interplanetary coronal mass ejection. The observed and estimated GIC based on the 3D GIC-SMAP procedure in the transmission line in southern Sweden are in good agreement. In contrast, 1D methods underestimate GICs by about 50%. The estimated GICs in the studied transmission line exceed 100 A for one of 14 historical geomagnetic storm intervals. The peak GIC during the sudden impulse phase of a "perfect" storm exceeds 300 A but depends on the locality of the station as the interplanetary magnetic cloud hits Earth.
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| 8. |
- Rosenqvist, L., et al.
(författare)
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3D Modeling of Geomagnetically Induced Currents in Sweden—Validation and Extreme Event Analysis
- 2022
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Ingår i: Space Weather. - : John Wiley & Sons. - 1542-7390. ; 20:3
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Tidskriftsartikel (refereegranskat)abstract
- Rosenqvist and Hall (2019), https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/2018SW002084 developed a proof-of-concept modeling capability that incorporates a detailed 3D structure of Earth's electrical conductivity in a geomagnetically induced current estimation procedure (GIC-SMAP). The model was verified based on GIC measurements in northern Sweden. The study showed that southern Sweden is exposed to stronger electric fields due to a combined effect of low crustal conductivity and the influence of the surrounding coast. This study aims at further verifying the model in this region. GIC measurements on a power line at the west coast of southern Sweden are utilized. The location of the transmission line was selected to include coast effects at the ocean-land interface to investigate the importance of using 3D induction modeling methods. The model is used to quantify the hazard of severe GICs in this particular transmission line by using historic recordings of strong geomagnetic disturbances. To quantify a worst-case scenario GICs are calculated from modeled magnetic disturbances by the Space Weather Modeling Framework based on estimates for an idealized extreme interplanetary coronal mass ejection. The observed and estimated GIC based on the 3D GIC-SMAP procedure in the transmission line in southern Sweden are in good agreement. In contrast, 1D methods underestimate GICs by about 50%. The estimated GICs in the studied transmission line exceed 100 A for one of 14 historical geomagnetic storm intervals. The peak GIC during the sudden impulse phase of a “perfect” storm exceeds 300 A but depends on the locality of the station as the interplanetary magnetic cloud hits Earth.
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