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Träfflista för sökning "WFRF:(Frossard L.) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Janier, M, et al. (författare) Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome 2022 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:3, s. 358-360 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
2.	Surendran, Praveen, et al. (författare) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals 2020 Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 52:12, s. 1314-1332 Tidskriftsartikel (refereegranskat)abstract Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
3.	Sarwar, N, et al. (författare) Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies 2010 Ingår i: Lancet (London, England). - 1474-547X .- 0140-6736. ; 375:9726, s. 1634-1639 Tidskriftsartikel (refereegranskat)
4.	Mahajan, A, et al. (författare) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 2014 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:3, s. 234- Tidskriftsartikel (refereegranskat)
5.	Villar, L, et al. (författare) Anti-lipid oligoclonal IgM bands contribute to progressive multifocal leukoencephalopathy (PML) risk stratification in multiple sclerosis patients treated with natalizumab 2013 Ingår i: MULTIPLE SCLEROSIS JOURNAL. - 1352-4585. ; 19:11, s. 56-57 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
6.	Burgess, S., et al. (författare) Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables 2010 Ingår i: Statistics in medicine. - : Wiley. - 1097-0258 .- 0277-6715. ; 29:12, s. 1298-311 Tidskriftsartikel (refereegranskat)abstract Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic markers measured in multiple studies, based on the analysis of individual participant data. First, for a single genetic marker in one study, we show that the usual ratio of coefficients approach can be reformulated as a regression with heterogeneous error in the explanatory variable. This can be implemented using a Bayesian approach, which is next extended to include multiple genetic markers. We then propose a hierarchical model for undertaking a meta-analysis of multiple studies, in which it is not necessary that the same genetic markers are measured in each study. This provides an overall estimate of the causal relationship between the phenotype and the outcome, and an assessment of its heterogeneity across studies. As an example, we estimate the causal relationship of blood concentrations of C-reactive protein on fibrinogen levels using data from 11 studies. These methods provide a flexible framework for efficient estimation of causal relationships derived from multiple studies. Issues discussed include weak instrument bias, analysis of binary outcome data such as disease risk, missing genetic data, and the use of haplotypes.
7.	Villar, LM, et al. (författare) Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab 2015 Ingår i: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 77:3, s. 447-457 Tidskriftsartikel (refereegranskat)
8.	Wensley, F, et al. (författare) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data 2011 Ingår i: BMJ (Clinical research ed.). - : BMJ. - 1756-1833 .- 0959-8138 .- 1468-5833. ; 342, s. d548- Tidskriftsartikel (refereegranskat)
9.	Danesh, J, et al. (författare) Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation 2008 Ingår i: European journal of epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 23:8, s. 531-540 Tidskriftsartikel (refereegranskat)
10.	Kehoe, Laura, et al. (författare) Make EU trade with Brazil sustainable 2019 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)

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Resultat 1-10 av 31

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Typ av publikation: tidskriftsartikel (27); konferensbidrag (4)

Typ av innehåll: refereegranskat (26); övrigt vetenskapligt/konstnärligt (5)

Författare/redaktör: Melander, Olle (9); Saleheen, D (8); Salomaa, Veikko (7); Perola, Markus (7); Rasheed, Asif (7); Saleheen, Danish (7); visa fler...; Danesh, J (7); Lind, Lars (6); Deloukas, Panos (6); Frossard, P (6); Zhao, Wei (6); Frossard, Philippe (6); Samani, Nilesh J. (6); Groop, Leif (5); Sattar, N. (5); Boehnke, Michael (5); Palmer, Colin N. A. (5); Kuulasmaa, Kari (5); Kathiresan, Sekar (5); Peters, A (4); Rolandsson, Olov (4); Collins, R (4); Ford, I. (4); Brown, M. (4); Hofman, A (4); Psaty, BM (4); Sattar, Naveed (4); Nordestgaard, BG (4); Laakso, Markku (4); Kumari, M (4); Orho-Melander, Marju (4); V Varga, Tibor (4); Langenberg, Claudia (4); Mohlke, Karen L (4); Ingelsson, Erik (4); Thorleifsson, Gudmar (4); Stefansson, Kari (4); Clarke, R (4); Khaw, KT (4); Beilby, J (4); Salomaa, V (4); Metspalu, Andres (4); Robertson, M (4); Kee, Frank (4); Karpe, Fredrik (4); Samani, NJ (4); Di Angelantonio, E (4); Blankenberg, Stefan (4); Hayward, Caroline (4); Gudnason, Vilmundur (4); visa färre...

Lärosäte: Karolinska Institutet (14); Lunds universitet (12); Göteborgs universitet (11); Umeå universitet (8); Uppsala universitet (8); Stockholms universitet (2); visa fler...; Kungliga Tekniska Högskolan (1); Mittuniversitetet (1); Chalmers tekniska högskola (1); Sveriges Lantbruksuniversitet (1); visa färre...

Språk: Engelska (31)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (22); Naturvetenskap (4); Teknik (1); Samhällsvetenskap (1)

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