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- Divaris, K., et al.
(författare)
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Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium
- 2022
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Ingår i: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 101:11, s. 1408-1416
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Tidskriftsartikel (refereegranskat)abstract
- Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 participants from 21 studies contributing clinical data on dental caries experience and periodontitis. We outline the methodological challenges of combining data from heterogeneous populations, as well as the data reduction problem in resolving detailed clinical examination records into tractable phenotypes, and describe a strategy that addresses this. Specifically, we propose a 3-tiered phenotyping approach aimed at leveraging both the large sample size in the consortium and the detailed clinical information available in some studies, wherein binary, severity-encompassing, and “precision,” data-driven clinical traits are employed. As an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies (N = 55,143) using previously developed permanent dentition tooth surface–level dental caries pattern traits. We demonstrate that these clinical patterns are transferable across multiple cohorts, have similar relative contributions within each study, and thus are prime targets for genetic interrogation in the expanded and diverse multiethnic sample of GLIDE2. We anticipate that results from GLIDE2 will decisively advance the knowledge base of mechanisms at play in oral, dental, and craniofacial health and disease and further catalyze international collaboration and data and resource sharing in genomics research.
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| 3. |
- Furuichi, N., et al.
(författare)
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Final report "Key comparison CCM.FF-K1.2015 - water flow : 30 m3/h ... 200 m3/h"
- 2022
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Ingår i: Metrologia. - : Institute of Physics. - 0026-1394 .- 1681-7575. ; 59:1 A
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Tidskriftsartikel (refereegranskat)abstract
- Main text The objective of the Key Comparison CCM.FF-K1.2015 for water flow measurement was to support and prove the Calibration and Measurement Capabilities (CMC) of the participating NMIs of Japan (AIST), Mexico (CENAM), Chinese Taipei (ITRI), Korea (KRISS), P.R. China (NIM), Germany (PTB), USA (NIST), Sweden (RISE), UK (NEL), Turkey (TUBITAK UME) and Netherlands (VSL). The comparison was organized as a round robin, started in December 2015 at PTB and finished in April 2018, also at PTB. As pilot laboratory, the national metrology institute of Germany (PTB) organised the comparison. A combined setup of a turbine meter and Coriolis meter was used as a transfer standard (TS), which was provided by the pilot laboratory. The nominal calibration conditions of the KC were defined within the flow range between 30 m3/h and 200 m3/h, 20 °C fluid temperature and 3 bar line pressure. A special focus of the comparison was to estimate the uncertainties of the transfer standard (u TS). Both transfer meters were subjected to extensive characterization measurements at pilot laboratory, with the following investigated parameters: fluid temperature, line pressure, repeatability, flow stability, meter sensitivity to varying inflow conditions and hysteresis effects. For turbine meter, all labs passed the E N criteria of ≤ 1.20. The calibrations of the turbine meter were strongly affected by the presence of the large values for u TS with > 0.12 % k =1) which were mainly caused by the meter sensitivity to disturbed inflow conditions. This effect led to inconclusive calibration results for all laboratories. The evaluation criteria u comp/u base exceeded the critical value of 2.00. Finally, the turbine meter was not suitable for a confirmation of all submitted CMC values. For Coriolis meter, all labs passed the E N criteria of ≤ 1.20. In contrast to turbine meter, the evaluation criteria u comp/u base exceeded the critical value of 2.00 for one laboratory, only. The maximum uncertainty u TS of Coriolis meter was estimated with 0.022 % (k =1). In summary, the comparison was successfully finished for a confirmation of the submitted CMC values, related to mass calibrations. For volume related CMCs this comparison was not suitable. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
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