SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Göpfert Caroline) "

Sökning: WFRF:(Göpfert Caroline)

  • Resultat 1-6 av 6
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Göpfert, Caroline, et al. (författare)
  • Biomechanical characteristics and speed adaptation during kick double poling on roller skis in elite cross-country skiers
  • 2013
  • Ingår i: Sports Biomechanics. - : Informa UK Limited. - 1476-3141 .- 1752-6116. ; 12:2, s. 154-174
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent developments in cross-country ski racing should promote the use of kick double poling. This technique, however, has not been the focus in athletes' training and has barely been investigated. The aims of the present study were to develop a function-based phase definition and to analyse speed adaptation mechanisms for kick double poling in elite cross-country skiers. Joint kinematics and pole/plantar forces were recorded in 10 athletes while performing kick double poling at three submaximal roller skiing speeds. A speed increase was associated with increases in cycle length and rate, while absolute poling and leg push-off durations shortened. Despite maintained impulses of force, the peak and average pole/leg forces increased. During double poling and leg push-off, ranges of motion of elbow flexion and extension increased (p < 0.05) and were maintained for hip/knee flexion and extension. Cycle length increase was correlated to increases in average poling force (r = 0.71) and arm swing time (r = 0.88; both p < 0.05). The main speed adaptation was achieved by changes in double poling technique; however, leg push-off showed high variability among elite skiers, thus illustrating important aspects for technique training.
  •  
3.
  • Lindinger, Stefan J, et al. (författare)
  • Biomechanical pole and leg characteristics during uphill diagonal rollerskiing
  • 2009
  • Ingår i: Sports Biomechanics. - : Informa UK Limited. - 1476-3141 .- 1752-6116. ; 8:4, s. 318-333
  • Tidskriftsartikel (refereegranskat)abstract
    • Diagonal skiing as a major classical technique has hardly been investigated over the last two decades, although technique and racing velocities have developed substantially. The aims of the present study were to 1) analyse pole and leg kinetics and kinematics during submaximal uphill diagonal roller skiing and 2) identify biomechanical factors related to performance. Twelve elite skiers performed a time to exhaustion (performance) test on a treadmill. Joint kinematics and pole/plantar forces were recorded separately during diagonal roller skiing (98; 11 km/h). Performance was correlated to cycle length (r ¼ 0.77; P , 0.05), relative leg swing (r ¼ 0.71), and gliding time (r ¼ 0.74), hip flexion range of motion (ROM) during swing (r ¼ 0.73) and knee extension ROM during gliding (r ¼ 0.71). Push-off demonstrated performance correlations for impulse of leg force (r ¼ 0.84), relative duration (r ¼ 20.76) and knee flexion (r ¼ 0.73) and extension ROM (r ¼ 0.74). Relative time to peak pole force was associated with performance (r ¼ 0.73). In summary, diagonal roller skiing performance was linked to 1) longer cycle length, 2) greater impulse of force during a shorter push-off with larger flexion/extension ROMs in leg joints, 3) longer leg swing, and 4) later peak pole force, demonstrating the major key characteristics to be emphasised in training.
  •  
4.
  •  
5.
  •  
6.
  • Mikus, Maria, et al. (författare)
  • Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury
  • 2016
  • Ingår i: Liver international. - : John Wiley & Sons. - 1478-3223 .- 1478-3231. ; 37:1, s. 132-140
  • Tidskriftsartikel (refereegranskat)abstract
    • Background & Aims: The occurrence of drug-induced liver injury (DILI) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI, we utilised an affinity proteomics strategy, where antibody suspension bead arrays were applied to profile plasma and serum samples from human DILI cases and controls. Methods: An initial screening was performed using 4594 randomly selected antibodies, representing 3450 human proteins. Resulting candidate proteins together with proposed DILI biomarker candidates generated a DILI array of 251 proteins for subsequent target analysis and verifications. In total, 1196 samples from 241 individuals across four independent cohorts were profiled: healthy volunteers receiving acetaminophen, patients with human immunodeficiency virus and/or tuberculosis receiving treatment, DILI cases originating from a wide spectrum of drugs, and healthy volunteers receiving heparins. Results: We observed elevated levels of cadherin 5, type 2 (CDH5) and fatty acid-binding protein 1 (FABP1) in DILI cases. In the two longitudinal cohorts, CDH5 was elevated already at baseline. FABP1 was elevated after treatment initiation and seemed to respond more rapidly than alanine aminotransferase (ALT). The elevations were verified in the DILI cases treated with various drugs. In the heparin cohort, CDH5 was stable over time whereas FABP1 was elevated. Conclusions: These results suggest that CDH5 may have value as a susceptibility marker for DILI. FABP1 was identified as a biomarker candidate with superior characteristics regarding tissue distribution and kinetics compared to ALT but likely with limited predictive value for the development of severe DILI. Further studies are needed to determine the clinical utility of the proposed markers.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-6 av 6

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy