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| 2. |
- Burman, Robert, et al.
(författare)
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Cyclotide proteins and precursors from the genus Gloeospermum : filling a blank spot in the cyclotide map of Violaceae
- 2010
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Ingår i: Phytochemistry. - : Elsevier BV. - 0031-9422 .- 1873-3700. ; 71:1, s. 13-20
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Tidskriftsartikel (refereegranskat)abstract
- Cyclotides are disulfide-rich plant proteins that are exceptional in their cyclic structure; their N and C termini are joined by a peptide bond, forming a continuous circular backbone, which is reinforced by three interlocked disulfide bonds. Cyclotides have been found mainly in the coffee (Rubiaceae) and violet (Violaceae) plant families. Within the Violaceae, cyclotides seem to be widely distributed, but the cyclotide complements of the vast majority of Violaceae species have not yet been explored. This study provides insight into cyclotide occurrence, diversity and biosynthesis in the Violaceae, by identifying mature cyclotide proteins, their precursors and enzymes putatively involved in their biosynthesis in the tribe Rinoreeae and the genus Gloeospermum. Twelve cyclotides from two Panamanian species, Gloeospermum pauciflorum Hekking and Gloeospermum blakeanum (Standl.) Hekking (designated Glopa A-E and Globa A-G, respectively) were characterised through cDNA screening and protein isolation. Screening of cDNA for the oxidative folding enzymes protein-disulfide isomerase (PDI) and thioredoxin (TRX) resulted in positive hits in both species. These enzymes have demonstrated roles in oxidative folding of cyclotides in Rubiaceae, and results presented here indicate that Violaceae plants have evolved similar mechanisms of cyclotide biosynthesis. We also describe PDI and TRX sequences from a third cyclotide-expressing Violaceae species, Viola biflora L., which further support this hypothesis.
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| 3. |
- Cadier, Filip, et al.
(författare)
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Nursing students' experiences with type 2 diabetes in Jordan: a qualitative content analysis
- 2017
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Ingår i: Home Health Care Management & Practice. - : SAGE Publications. - 1084-8223 .- 1552-6739. ; 29:2, s. 103-110
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Tidskriftsartikel (refereegranskat)abstract
- Prevalence of type 2 diabetes has increased worldwide due to lifestyle factors, such as obesity and inactivity and nurses have an essential role in supporting healthy life situations. The aim was to describe nursing students' experiences with type 2 diabetes in Jordan regard to prevention and nursing care. Interviews with eight nursing students were performed. Data were analyzed using content analysis. One category and two subcategories were generated: managing challenges in daily life to prevent type 2 diabetes and promote patient safety, managing risk factors, and dealing with difficulties. Empowerment and person-centered care are tools to increase patients’ self-care to motivate them to live a healthy lifestyle within the whole family to prevent and decrease illness.
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| 4. |
- Capelan, Annika, et al.
(författare)
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Deltagande observationer
- 2021
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Ingår i: Kvalitativa metoder helt enkelt!. ; , s. 117-139
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Cederquist, Kristina, et al.
(författare)
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Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden
- 2004
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 109:3, s. 370-376
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder that predisposes to predominantly colorectal and endometrial cancers due to germline mutations in DNA mismatch repair genes, mainly MLH1, MSH2 and in families with excess endometrial cancer also MSH6. In this population-based study, we analysed the mutation spectrum of the MLH1, MSH2 and MSH6 genes in a cohort of patients with microsatellite unstable double primary tumours of the colorectum and the endometrium by PCR, DHPLC and sequencing. Fourteen of the 23 patients (61%) had sequence variants in MLH1, MSH2 or MSH6 that likely affect the protein function. A majority (10/14) of the mutations was found among probands diagnosed before age 50. Five of the mutations (36%) were located in MLH1, 3 (21%) in MSH2 and 6 (43%) in MSH6. MSH6 seem to have larger impact in our population than in other populations, due to a founder effect since all of the MSH6 families originate from the same geographical area. MSH6 mutation carriers have later age of onset of both colorectal cancer (62 vs. 51 years) and endometrial cancer (58 vs. 48 years) and a larger proportion of endometrial cancer than MLH1 or MSH2 mutation carriers. We can conclude that patients with microsatellite unstable double primary cancers of the colorectum and the endometrium have a very high risk of carrying a mutation not only in MLH1 or MSH2 but also in MSH6, especially if they get their first cancer diagnosis before the age of 50. Copyright 2004 Wiley-Liss, Inc.
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| 7. |
- Eklund, Lisa, et al.
(författare)
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The moral imperative of children’s academic excellence: Tensions and contradictions in Chinese middle-class parenting styles
- 2023
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- It is well documented that Chinese parents invest enormous amounts of time, resources and emotions in their children’s education, as if a life worthwhile is a life where education and self-cultivation is at the fore. Taking part in and excelling in educational activities is a moral imperative that marks childhood, whereby achieving in school is not only an act of filial piety, but also a patriotic deed, where the good-student-subject contributes to the advancement of the nation. Educational desire, seen across China and other East Asian societies, feeds off and contributes to an intrinsic web of subjects and public and private institutions that govern themselves as much as they are governed by the state. One key set of actors, subsumed in this web, is parents who both set goals and aspirations for their children’s academic achievement, and manage, support and coach their children in achieving these goals, often with the help of tutors and extra-curricular schools. This paper explores some of the tensions and contradictions in Chinese middle-class parenting styles aiming at academic excellence on part of their young children. Drawing on fieldwork in Beijing, Shanghai and Singapore, various norms and practices are delineated, pointing at tensions and contradictions of the moral imperative of children’s academic excellence. As we show, these tensions cannot be understood without taking into account aspirations for social mobility and intergenerational relations on the one hand, and concerns over (mental) health and wellbeing and the moral imperative of being a good parent on the other hand.
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| 8. |
- Goh, Esther Chor Leng, et al.
(författare)
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Doing Ethnographic Research in Chinese Families: Reflections on Methodological Concerns from Two Asian Cities
- 2011
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Ingår i: International Journal of Qualitative Methods. - 1609-4069. ; 10:3, s. 265-281
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Tidskriftsartikel (refereegranskat)abstract
- This paper compares and contrasts the ethnographic practices of two non-native researchers – a Singaporean researcher studying families in mainland China and a Swedish researcher studying Chinese families in Singapore. A novel conceptual frame of ‘radius of observation positions’ has been proposed to explicate the extent of intrusion and intimacy to which researchers may venture in the private family domain. The opportunities and challenges of two positions of observation within this radius are discussed. The choice of position is largely influenced by the interacting forces of the contextual and cultural factors as well as the personhood of the researcher. The authors call for special attention to cultural sensitivity in conducting Chinese family research. Families are embedded in culture, and the possibility of accessing family spaces hinges on one’s awareness of the intricacies of family cultures and realistic assessment of one’s strengths and limitations in handling complex family dynamics.
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| 9. |
- Göransson, Carina, 1967-, et al.
(författare)
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An app for supporting older people receiving home care - usage, aspects of health and health literacy : a quasi-experimental study
- 2020
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Ingår i: BMC Medical Informatics and Decision Making. - London : BioMed Central. - 1472-6947. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: During the last decade, there has been an increase in studies describing use of mHealth, using smartphones with apps, in the healthcare system by a variety of populations. Despite this, few interventions including apps are targeting older people receiving home care. Developing mobile technology to its full potential of being interactive in real time remains a challenge. The current study is part of a larger project for identifying and managing health concerns via an app by using real-time data. The aim of the study was to describe older people's usage of an app and to evaluate the impact of usage on aspects of health and health literacy over time.METHODS: A quasi-experimental design was employed. Seventeen older people self-reported health concerns via Interaktor twice a week for 3-months and answered questionnaires at baseline, the end of the intervention and at a 6-month follow-up. Logged data on app usage and data on Sense of Coherence, Health Index, Nutrition Form for the Elderly, Geriatric Depression Scale-20, Swedish Communicative and Critical Health Literacy and Swedish Functional Health Literacy were collected and analysed using descriptive and non-parametric inferential statistics.RESULTS: The median usage of the app as intended was 96%. Pain was one of the most reported health concerns and was also the health concern that triggered an alert (n = 33). The older people's communicative and critical health literacy improved significantly over time. Regarding the scores of Sense of Coherence, Health Index, Nutritional Form for the Elderly, Geriatric Depression Scale-20 and Swedish Functional Health Literacy scale, there were no significant differences over time.CONCLUSIONS: The high app usage showed that an app may be a suitable tool for some older people living alone and receiving home care. The results indicate that the usage of Interaktor can support older people by significantly improving their communicative and critical health literacy. Aspects of health were not shown to be affected by the usage of the app. Further research with larger sample is needed for evaluation the effect on health literacy, and which aspects of health of importance to support by an app.
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| 10. |
- Göransson, Carina, 1967-
(författare)
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Developing and evaluating an interactive app to support self-care among older persons receiving home care
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The proportion of older persons worldwide is growing. With older age, complex health problems may occur and the need for home care increases. To support older persons to maintain health and self-care, innovative ways need to be developed. The aim of the project was to develop and evaluate an interactive app among older persons receiving home care. The project had several phases: i) to define and understand the problem ii) develop the intervention iii) develop and optimise evaluation. Qualitative and quantitative methods were employed. Data were collected through a scoping review, interviews with healthcare experts, older persons and nursing assistants (study I); interviews with older persons (studies II, III); focus groups with homecare nurses (study II). Questionnaires at baseline, end of intervention and 6-month follow-up; with instruments to assess aspects of health, health literacy, self-care, and a study specific question regarding sense of security were used (studies III-IV). Logged data from reported health concerns, alerts, and notes were collected (study IV). Data were analysed using qualitative content analysis (study I), thematic analysis (study II), qualitative content analysis with directed approach (study III) and descriptive and inferential statistics (studies III, IV). Results: Important aspects for health and self-care from the older persons’ perspectives were described as: frame of mind, having relationships and social activities, physical ability and concerns, and maintaining self-care (I). These results were included in the app as questions with self-care advice, graphs and alerts to homecare nurses. The app use was described as an enabler for learning (II). The older persons showed improved communicative and critical health literacy at the 6- month follow-up (IV). They described an increased sense of security (II and III), which decreased at the 6-month follow-up (III). They expressed increased self-confidence (II) and support in self-care, but reported a decrease in self-care ability at the 6-month follow-up (III). App usage was high, with the health concern pain triggering the most alerts (IV). Their aspects of health were unchanged at the three assessments points (IV). In this context using an app may increase older persons’ participation in their care. The results show that for some older persons, an app can be implemented as a tool for support in conventional home care.
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