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- Gøtze, Jens Peter, et al.
(författare)
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Ny markør ved trombotisk trombocytopenisk purpura
- 2008
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Ingår i: Ugeskrift for Laeger. - 0041-5782. ; 170:33, s. 9-2446
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Forskningsöversikt (refereegranskat)abstract
- Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
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