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Sökning: WFRF:(Gabrielsson L.)

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  • Andersson, R., et al. (författare)
  • Dose-response-time modelling: Second-generation turnover model with integral feedback control
  • 2016
  • Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 81, s. 189-200
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2015 Elsevier B.V. All rights reserved. This study presents a dose-response-time (DRT) analysis based on a large preclinical biomarker dataset on the interaction between nicotinic acid (NiAc) and free fatty acids (FFA). Data were collected from studies that examined different rates, routes, and modes of NiAc provocations on the FFA time course. All information regarding the exposure to NiAc was excluded in order to demonstrate the utility of a DRT model. Special emphasis was placed on the selection process of the biophase model. An inhibitory Imax-model, driven by the biophase amount, acted on the turnover rate of FFA. A second generation NiAc/FFA model, which encompasses integral (slow buildup of tolerance - an extension of the previously used NiAc/FFA turnover models) and moderator (rapid and oscillatory) feedback control, was simultaneously fitted to all time courses in normal rats. The integral feedback control managed to capture an observed 90% adaptation (i.e., almost a full return to baseline) when 10 days constant-rate infusion protocols of NiAc were used. The half-life of the adaptation process had a 90% prediction interval between 3.5-12 in the present population. The pharmacodynamic parameter estimates were highly consistent when compared to an exposure-driven analysis, partly validating the DRT modelling approach and suggesting the potential of DRT analysis in areas where exposure data are not attainable. Finally, new numerical algorithms, which rely on sensitivity equations to robustly and efficiently compute the gradients in the parameter optimization, were successfully used for the mixed-effects approach in the parameter estimation.
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  • Deckner, F., et al. (författare)
  • Jordförstärkning
  • 2010
  • Rapport (övrigt vetenskapligt/konstnärligt)
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  • Gabrielsson, A, et al. (författare)
  • Thermal energy storage in soils at temperatures reaching 90 degrees C
  • 2000
  • Ingår i: Journal of solar energy engineering. - 0199-6231 .- 1528-8986. ; 122:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Using soil and groundwater for heat storage offers an opportunity to increase the potential for renewable energy sources. For example, solar heating in combination with high temperature storage, e.g., using ducts in the ground, has the potential of becoming an environment friendly and economically competitive form of heat supply. Technology is developed to reduce ground construction costs and to ensure that adequate attention is paid to the geotechnical potentials and limitations of such systems, in the temperature range between neutral ground temperature up to 90 degreesC. Investigations of real plants and in the laboratory have given valuable knowledge on the thermal effects on clayey soils as well as on the surroundings of high temperature stores in soft clay. The operational function of heat stores, with respect to heat transfer capacity of ground heat exchangers and heat losses, can be predicted with good agreement. For the uppermost part of the temperature range, long term performance, cost verification and thermal endurance of materials involved including the storage medium, is recommended using a full-scale demonstration plant.
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