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Träfflista för sökning "WFRF:(Garmendia Eva PhD 1989 ) "

Sökning: WFRF:(Garmendia Eva PhD 1989 )

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Numrering	Referens	Omslagsbild	Hitta
1.	Garbovan, Lidis, et al. (författare) Impactful approaches for community-wide engagement on antibiotic resistance : An initiative to promote systematic and meaningful engagement of communities and civil society groups as key stakeholdersin the global response to antibiotic resistance 2024 Rapport (populärvet., debatt m.m.)abstract This report presents the synopsis and outcomes of a series of webinars and a workshop that took place during the fall of 2023. The series showcased and discussed approaches to community engagement (CE) on antibiotic resistance from diverse settings and contexts across the globe. It explored different methods used, success factors, and ways to measure impact, while highlighting barriers and enablers for community engagement and harnessing key learnings from stakeholders and academics involved in the initiative.The report summarizes key ideas and take-away messages from the in-depth discussions between the participants. The intended aim of the report is to outline key learnings and messages about CE on antibiotic resistance that can be applied in multiple contexts to support present and future community initiatives, education, and ongoing policy processes.
2.	McGrath, Kaitlyn M., et al. (författare) Fitness benefits of a synonymous substitution in an ancient EF-Tu gene depend on the genetic background 2024 Ingår i: Journal of Bacteriology. - : American Society for Microbiology. - 0021-9193 .- 1098-5530. Tidskriftsartikel (refereegranskat)abstract Synonymous mutations are changes to DNA sequence, which occur within translated genes but which do not affect the protein sequence. Although often referred to as silent mutations, evidence suggests that synonymous mutations can affect gene expression, mRNA stability, and even translation efficiency. A collection of both experimental and bioinformatic data has shown that synonymous mutations can impact cell phenotype, yet less is known about the molecular mechanisms and potential of beneficial or adaptive effects of such changes within evolved populations. Here, we report a beneficial synonymous mutation acquired via experimental evolution in an essential gene variant encoding the translation elongation factor protein EF-Tu. We demonstrate that this particular synonymous mutation increases EF-Tu mRNA and protein levels as well as global polysome abundance on RNA transcripts. Although presence of the synonymous mutation is clearly causative of such changes, we also demonstrate that fitness benefits are highly contingent on other potentiating mutations present within the genetic background in which the mutation arose. Our results underscore the importance of beneficial synonymous mutations, especially those that affect levels of proteins that are key for cellular processes.

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Typ av publikation: rapport (1); tidskriftsartikel (1)

Typ av innehåll: populärvet., debatt m.m. (1); refereegranskat (1)

Författare/redaktör: Garmendia, Eva, PhD, ... (2); Caputo, Andrea (1); Pränting, Maria (1); Kacar, Betul (1); Fer, Evrim (1); McGrath, Kaitlyn M. (1); visa fler...; Garbovan, Lidis (1); Russell, Steven J. (1); Hosgel, Ali (1); Baltrus, David A. (1); visa färre...

Lärosäte: Uppsala universitet (2)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Naturvetenskap (1); Medicin och hälsovetenskap (1)

År: 2024 (2)

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