| 1. |
- Battiston, R., et al.
(författare)
-
High precision particle astrophysics as a new window on the universe with an Antimatter Large Acceptance Detector In Orbit (ALADInO)
- 2021
-
Ingår i: Experimental astronomy. - : Springer Science and Business Media B.V.. - 0922-6435 .- 1572-9508. ; 51:3, s. 1299-1330
-
Tidskriftsartikel (refereegranskat)abstract
- Multimessenger astrophysics is based on the detection, with the highest possible accuracy, of the cosmic radiation. During the last 20 years, the advent space-borne magnetic spectrometers in space (AMS-01, Pamela, AMS-02), able to measure the charged cosmic radiation separating matter from antimatter, and to provide accurate measurement of the rarest components of Cosmic Rays (CRs) to the highest possible energies, have become possible, together with the ultra-precise measurement of ordinary CRs. These developments started the era of precision Cosmic Ray physics providing access to a rich program of high-energy astrophysics addressing fundamental questions like matter-antimatter asymmetry, indirect detection for Dark Matter and the detailed study of origin, acceleration and propagation of CRs and their interactions with the interstellar medium. In this paper we address the above-mentioned scientific questions, in the context of a second generation, large acceptance, superconducting magnetic spectrometer proposed as mission in the context of the European Space Agency’s Voyage2050 long-term plan: the Antimatter Large Acceptance Detector In Orbit (ALADInO) would extend by about two orders of magnitude in energy and flux sensitivity the separation between charged particles/anti-particles, making it uniquely suited for addressing and potentially solving some of the most puzzling issues of modern cosmology.
|
|
| 2. |
|
|
| 3. |
- Boguszewski, M. C. S., et al.
(författare)
-
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement
- 2022
-
Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 186:6
-
Tidskriftsartikel (refereegranskat)abstract
- Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. With the support of the European Society of Endocrinology, the Growth Hormone Research Society convened a Workshop, where 55 international key opinion leaders representing 10 professional societies were invited to participate. This consensus statement utilized: (1) a critical review paper produced before the Workshop, (2) five plenary talks, (3) evidence-based comments from four breakout groups, and (4) discussions during report-back sessions. Current evidence reviewed from the proceedings from the Workshop does not support an association between GH replacement and primary tumour or cancer recurrence. The effect of GH replacement on secondary neoplasia risk is minor compared to host- and tumour treatment-related factors. There is no evidence for an association between GH replacement and increased mortality from cancer amongst GH-deficient childhood cancer survivors. Patients with pituitary tumour or craniopharyngioma remnants receiving GH replacement do not need to be treated or monitored differently than those not receiving GH. GH replacement might be considered in GH-deficient adult cancer survivors in remission after careful individual risk/benefit analysis. In children with cancer predisposition syndromes, GH treatment is generally contraindicated but may be considered cautiously in select patients.
|
|
| 4. |
|
|
| 5. |
- Rixen, M., et al.
(författare)
-
First Real-Life Data on the Diving Response in Healthy Children
- 2024
-
Ingår i: Pediatric Cardiology. - : Springer Nature. - 0172-0643 .- 1432-1971. ; 45:2, s. 314-322
-
Tidskriftsartikel (refereegranskat)abstract
- Swimming and diving are popular recreational activities, representing an effective option in maintaining and improving cardiovascular fitness in healthy people. To date, only little is known about the cardiovascular adaption to submersion in children. This study was conducted to improve an understanding thereof. We used a stepwise apnea protocol with apnea at rest, apnea with facial immersion, and at last apnea during whole body submersion. Continuous measurement of heart rate, oxygen saturation, and peripheral resistance index was done. Physiologic data and analysis of influencing factors on heart rate, oxygen saturation, and peripheral vascular tone response are reported. The current study presents the first data of physiologic diving response in children. Data showed that facial or whole body submersion leads to a major drop in heart rate, and increase of peripheral resistance, while the oxygen saturation seems to be unaffected by static apnea in most children, with apnea times of up to 75 s without change in oxygen saturation.
|
|
