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Sökning: WFRF:(Geczy C. L.)

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1.
  • Mortari, Alessia, et al. (författare)
  • Applications of protein-based capacitive biosensors for the detection of heavy-metal ions
  • 2006
  • Ingår i: 2006 International Conference on Nanoscience and Nanotechnology (IEEE Cat. No.06EX1411). - 1424404525 ; , s. 304-307
  • Konferensbidrag (refereegranskat)abstract
    • Three different methods of using protein-based capacitive biosensors for the detection of heavy-metal ions are presented. The metal-binding proteins SmtA, S100A12, MerP and four modified MerPs were immobilised as the bio-recognition element on self-assembled monolayer-modified gold electrodes. Capacitance was measured using potential square step or electrical impedance spectroscopy. The protein-metal interaction generated changes in capacitance mainly due to a protein conformational change.
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2.
  • Shepherd, C. E., et al. (författare)
  • Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease
  • 2006
  • Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 27:11, s. 1554-1563
  • Tidskriftsartikel (refereegranskat)abstract
    • Inflammation, insoluble protein deposition and neuronal cell loss are important features of the Alzheimer's disease (AD) brain. S100B is associated with the neuropathological hallmarks of AD where it is thought to play a role in neuritic pathology. S100A8, S100A9 and S100A12 comprise anew group of inflammation-associated proteins that are constitutively expressed by neutrophils and inducible in numerous inflammatory cells. We investigated expression of S100B, S100A8, S100A9 and S100A12 in brain samples from sporadic and familial (PS-1) AD cases and controls using immunohistochemistry and Western blot analysis. S100B, S100A9 and S100A12, but not S100A8, were consistently associated with the neuropathological hallmarks of AD. Western blot analysis confirmed significant increases in soluble S100A9 in PS-1 AD compared to controls. S100A9 complexes that were resistant to reduction were also evident in brain extracts. A reactive component of a size consistent with hexameric S100A12 was seen in all cases. This study indicates a potential role for pro-inflammatory S100A9 and S100A12 in pathogenesis caused by inflammation and protein complex formation in AD.
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  • Resultat 1-2 av 2
Typ av publikation
konferensbidrag (1)
tidskriftsartikel (1)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Yang, Z. (1)
Martin, D (1)
Halliday, G. M. (1)
Csöregi, Elisabeth (1)
Mortari, Alessia (1)
Brown, N L (1)
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Shepherd, C. E. (1)
Geczy, C. (1)
Coster, H.G.L. (1)
Valenzuela, S.M. (1)
Goyette, J. (1)
Utter, V. (1)
Rahimi, F. (1)
Geczy, C. L. (1)
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Uppsala universitet (1)
Lunds universitet (1)
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Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
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2006 (2)

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