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Sökning: WFRF:(Gedeon C)

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  • Abrahamsson, Tove, et al. (författare)
  • Interim Buprenorphine Treatment in Opiate Dependence: A Pilot Effectiveness Study.
  • 2016
  • Ingår i: Substance Abuse. - : Informa UK Limited. - 0889-7077 .- 1547-0164. ; 37:1, s. 104-104
  • Tidskriftsartikel (refereegranskat)abstract
    • Interim methadone treatment (i.e. temporary medication-only treatment) has been tested in a few US studies as a method for facilitated referral to and initiation of opioid maintenance treatment in heroin dependence. However, despite the favorable safety profile of buprenorphine compared to methadone, interim treatment with buprenorphine rarely has been tested and reported in the scientific literature. The present pilot effectiveness study aims to assess the feasibility of an interim buprenorphine treatment for initiation of individuals with opiate dependence into full-scale opioid maintenance treatment, and to study baseline predictors of successful transfer to full-scale treatment.
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  • Håkansson, Anders C, et al. (författare)
  • Correlates of Nine-Month Retention following Interim Buprenorphine-Naloxone Treatment in Opioid Dependence: A Pilot Study.
  • 2016
  • Ingår i: Journal of addiction. - : Hindawi Limited. - 2090-7834 .- 2090-7850. ; 2016
  • Tidskriftsartikel (refereegranskat)abstract
    • Interim medication-only treatment has been suggested for the initiation of opioid maintenance treatment (OMT) in opioid-dependent subjects, but this rarely has been studied using buprenorphine instead of methadone. Following a pilot trial assessing interim buprenorphine-naloxone treatment in order to facilitate transfer into OMT, we here aimed to study retention, and potential correlates of retention, in full-scale treatment. Thirty-six patients successfully referred from a waiting list through an interim treatment phase were followed for nine months in OMT. Baseline characteristics, as well as urine analyses during the interim phase and during full-scale OMT, were studied as potential correlates of retention. The nine-month retention in OMT was 83 percent (n = 30). While interim-phase urine samples positive for benzodiazepines did not significantly predict dropout from full-scale OMT (p = 0.09), urine samples positive for benzodiazepines within full-scale OMT were significantly associated with dropout (p < 0.01), in contrast to other substances and baseline characteristics. Retention remained high through nine months in this pilot study sample of patients referred through buprenorphine-naloxone interim treatment, but use of benzodiazepines is problematic, and the present data suggest that it may be associated with treatment dropout.
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