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Sökning: WFRF:(Gentile Ugo)

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1.
  • Ammirati, Enrico, et al. (författare)
  • Acute Myocarditis Associated With Desmosomal Gene Variants
  • 2022
  • Ingår i: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 10:10, s. 714-727
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation.
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2.
  • Flammini, Francesco, Senior Lecturer, 1978-, et al. (författare)
  • A Petri Net pattern-oriented approach for the design of physical protection systems
  • 2014
  • Ingår i: Computer Safety, Reliability, and Security. SAFECOMP 2014. - Cham : Springer. - 9783319105055 ; , s. 230-245
  • Konferensbidrag (refereegranskat)abstract
    • The design of complex Physical Protection Systems (PPSs) still raises some challenges despite the high number of technologies for smart surveillance. One reason is the lack of effective methodologies able to support the PPS designer in evaluating the effectiveness of the system on varying design choices. Indeed, an estimation of the system vulnerability should be performed in the early phases of the PPS design. This paper introduces a model-based methodology for the quantitative estimation of the vulnerability of a PPS. The proposed methodology clearly defines a compositional approach which takes advantage from the usage of predefined patterns for the creation of vulnerability models. In particular, the paper proposes some Petri Net patterns able to capture the behavioural aspects of several assets and actors involved in attacking/defending scenarios. © 2014 Springer International Publishing.
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