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- Priyadarshini, Diana, et al.
(författare)
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Enzymatically Polymerized Organic Conductors on Model Lipid Membranes
- 2023
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Ingår i: Langmuir. - : AMER CHEMICAL SOC. - 0743-7463 .- 1520-5827. ; 39:23, s. 8196-8204
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Tidskriftsartikel (refereegranskat)abstract
- Seamless integration between biological systems and electricalcomponents is essential for enabling a twinned biochemical-electricalrecording and therapy approach to understand and combat neurologicaldisorders. Employing bioelectronic systems made up of conjugated polymers,which have an innate ability to transport both electronic and ioniccharges, provides the possibility of such integration. In particular,translating enzymatically polymerized conductive wires, recently demonstratedin plants and simple organism systems, into mammalian models, is ofparticular interest for the development of next-generation devicesthat can monitor and modulate neural signals. As a first step towardachieving this goal, enzyme-mediated polymerization of two thiophene-basedmonomers is demonstrated on a synthetic lipid bilayer supported ona Au surface. Microgravimetric studies of conducting films polymerizedin situ provide insights into their interactions with a lipid bilayermodel that mimics the cell membrane. Moreover, the resulting electricaland viscoelastic properties of these self-organizing conducting polymerssuggest their potential as materials to form the basis for novel approachesto in vivo neural therapeutics.
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| 2. |
- Sahalianov, Ihor, et al.
(författare)
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Tuning the Emission of Bis-ethylenedioxythiophene-thiophenes upon Aggregation
- 2024
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Ingår i: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. - 1520-6106 .- 1520-5207. ; 128:27, s. 6581-6588
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Tidskriftsartikel (refereegranskat)abstract
- The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to implanting deep brain stimulation probes could involve administering small molecule precursors intravenously, capable of crossing the blood-brain barrier, and initiating the formation of conductive polymer networks in the brain through in vivo polymerization. This study examines the aggregation behavior of five water-soluble conducting polymer precursors sharing the same conjugate core but differing in side chains, using spectroscopy and various computational chemistry tools. Our findings highlight the significant impact of side chain composition on both aggregation and spectroscopic response.
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