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Sökning: WFRF:(Ghafari Robab)

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1.
  • Ghafari, Robab, et al. (författare)
  • Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications
  • 2019
  • Ingår i: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 136, s. 796-803
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.
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2.
  • Ghafari, Robab, et al. (författare)
  • Processing-structure-property relationships of electrospun PLA-PEO membranes reinforced with enzymatic cellulose nanofibers
  • 2020
  • Ingår i: Polymer Testing. - : Elsevier BV. - 0142-9418. ; 81
  • Tidskriftsartikel (refereegranskat)abstract
    • Three different solvent mixtures were used to prepare electrospun membranes based on polylactic acid (PLA), polyethylene oxide (PEO) and enzymatic cellulose nanofibers (CNF). The materials were characterized from a morphological, spectroscopic, mechanical and rheological point of view. Furthermore, swelling test were performed in order to assess the water uptake of each sample. The results put into evidence that the choice of the solvents affects the structure and the properties of the membranes. Among the protocols tested, using chloroform/acetone/ethanol mixture was found to allow a high degree of CNF dispersion and a good electrospinnability of polymer solutions. These features led to membranes with impressive improvement of mechanical properties (+350% in stiffness, +350% in tensile strength and +500% in toughness) with respect to those of PLA/PEO and dramatically increased the water uptake of these materials (up to +350% within 120 min).
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