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- Carmona-Gutierrez, D., et al.
(författare)
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Guidelines and recommendations on yeast cell death nomenclature
- 2018
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Ingår i: Microbial Cell. - : Shared Science Publishers OG. - 2311-2638. ; 5:1, s. 4-31
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Forskningsöversikt (refereegranskat)abstract
- Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.
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| 3. |
- Consolini, G., et al.
(författare)
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On the scaling features of magnetic field fluctuations at non-MHD scales in turbulent space plasmas
- 2016
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Ingår i: 15th Annual International Astrophysics Conference. - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- In several different contexts space plasmas display intermittent turbulence at magneto-hydro-dynamic (MHD) scales, which manifests in anomalous scaling features of the structure functions of the magnetic field increments. Moving to smaller scales, i.e. below the ion-cyclotron and/or ion inertial length, these scaling features are still observed, even though its is not clear if these scaling features are still anomalous or not. Here, we investigate the nature of scaling properties of magnetic field increments at non-MHD scales for a period of fast solar wind to investigate the occurrence or not of multifractal features and collapsing of probability distribution functions (PDFs) using the novel Rank-Ordered Multifractal Analysis (ROMA) method, which is more sensitive than the traditional structure function approach. We find a strong evidence for the occurrence of a near mono-scaling behavior, which suggests that the observed turbulent regime at non-MHD scales mainly displays a mono-fractal nature of magnetic field increments. The results are discussed in terms of a non-compact fractal structure of the dissipation field.
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| 5. |
- Kosar, M, et al.
(författare)
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 3937-
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Tidskriftsartikel (refereegranskat)abstract
- Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. DNA fiber assays and electron microscopy visualization of replication intermediates show that Tpr deficient cells exhibit slow and asymmetric replication forks under replication stress. Tpr deficiency evokes enhanced levels of DNA-RNA hybrids. Additionally, complementary proteomic strategies identify a network of Tpr-interacting proteins mediating RNA processing, such as MATR3 and SUGP2, and functional experiments confirm that their depletion trigger cellular phenotypes shared with Tpr deficiency. Mechanistic studies reveal the interplay of Tpr with GANP, a component of the TREX-2 complex. The Tpr-GANP interaction is supported by their shared protein level alterations in a cohort of ovarian carcinomas. Our results reveal links between nucleoporins, DNA transcription and replication, and the existence of a network physically connecting replication forks with transcription, splicing, and mRNA export machinery.
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