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- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 3. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Gil Álvarez, Mar, et al.
(författare)
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Mapping Existential Loneliness : A Scoping Review on Existential Loneliness/Isolation Conceptualizations and Operationalizations
- 2023
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Ingår i: Journal of Humanistic Psychology. - : SAGE Publications Inc.. - 0022-1678 .- 1552-650X.
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Forskningsöversikt (refereegranskat)abstract
- In the last decade, there has been a renewed interdisciplinary interest in the study of existential loneliness (EL) or existential isolation (EI). However, to date, there is still no consensus in the literature on what exactly EL/EI is and how should be measured, resulting in a wide variety of definitions and operationalizations of the experience. Therefore, this scoping review provides an overview of the available terminology, definitions, and operationalizations of EL/EI. As part of the review corpus, a total of 121 reports out of 12 databases were included. In the text, first, an examination of the terms and conceptualizations commonly used to discuss EL/EI is provided. Second, key components of the available definitions in the literature are listed. Third, most common operationalizations of EL/EI are described. Taking this into account, this scoping review sheds light on how the variety of conceptualizations of EL/EI leads to significant differences in the operationalization of the experience, fostering the development of academic niches and the fragmentation of EL/EI scientific knowledge. Thus, this review is an attempt to map commonalities in the EL/EI literature that may enable the reader to understand what exactly it means to explore the existential dimension of loneliness.
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