SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Gil Sevillano J) "

Sökning: WFRF:(Gil Sevillano J)

  • Resultat 1-5 av 5
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • de Rojas, I., et al. (författare)
  • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
  • 2021
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
  •  
2.
  • Martinez-Perez, M L, et al. (författare)
  • Measurement and modelling of residual stresses in straightened commercial eutectoid steel rods
  • 2005
  • Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454 .- 1873-2453. ; 53:16, s. 4415-4425
  • Tidskriftsartikel (refereegranskat)abstract
    • Neutron strain scanning measurements on a eutectoid steel rod that has been subjected to standard industrial coiling and straightening operations are presented. Strains were determined non-destructively using two different diffractometers, one at a steady-state neutron source and the other at a pulsed spallation neutron source, with measurements made in both the ferrite and cementite components of the pearlitic microstructure. The residual stress state is explained in terms of a simplified analytical model for a two-phase material, which takes into account the successive loading operations contributing to residual stress. The results show that residual stresses generated by bending–straightening operations are significant and are likely to play an important role in the mechanical properties of the final wires.
  •  
3.
  •  
4.
  •  
5.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-5 av 5

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy