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Träfflista för sökning "WFRF:(Giles M.) "

Search: WFRF:(Giles M.)

  • Result 1-10 of 634
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1.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Thomas, HS, et al. (author)
  • 2019
  • swepub:Mat__t
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  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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10.
  • Feroci, M., et al. (author)
  • The large observatory for x-ray timing
  • 2014
  • In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9780819496126
  • Conference paper (peer-reviewed)abstract
    • The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.
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  • Result 1-10 of 634
Type of publication
journal article (600)
research review (16)
conference paper (12)
book chapter (3)
other publication (1)
Type of content
peer-reviewed (603)
other academic/artistic (29)
Author/Editor
Giles, GG (199)
Giles, Graham G (174)
Easton, DF (142)
Southey, MC (138)
Chang-Claude, J (133)
Hall, P (128)
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Fasching, PA (127)
Brenner, H (125)
Czene, K (124)
Hopper, JL (123)
Milne, RL (122)
Dunning, AM (121)
Couch, FJ (116)
Cox, A (111)
Haiman, CA (111)
Beckmann, MW (110)
Garcia-Closas, M (110)
Pharoah, PDP (110)
Wolk, Alicja (109)
Bojesen, SE (105)
Nevanlinna, H (105)
Mannermaa, A (103)
Dork, T (103)
Chenevix-Trench, G (102)
Dennis, J (101)
Lambrechts, D (101)
Bolla, MK (99)
Brauch, H (98)
Schmidt, MK (98)
Andrulis, IL (97)
Russell, C. T. (96)
Hamann, U (95)
Wang, Q. (94)
Giles, B. L. (93)
Lindblom, A (91)
Burwinkel, B (91)
Anton-Culver, H (90)
Margolin, S (90)
Lubinski, J (90)
Zheng, W. (88)
Benitez, J. (88)
Jakubowska, A (87)
Devilee, P (86)
Ergun, R. E. (86)
Le Marchand, L (85)
Flyger, H (85)
Arndt, V (83)
Peto, J (82)
Guenel, P (82)
Truong, T (82)
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University
Karolinska Institutet (380)
Uppsala University (272)
Umeå University (112)
Royal Institute of Technology (99)
Lund University (89)
Stockholm University (17)
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University of Gothenburg (14)
Chalmers University of Technology (11)
Linköping University (9)
Högskolan Dalarna (2)
Swedish University of Agricultural Sciences (2)
The Nordic Africa Institute (1)
Örebro University (1)
Jönköping University (1)
Stockholm School of Economics (1)
Linnaeus University (1)
University of Borås (1)
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Language
English (634)
Research subject (UKÄ/SCB)
Medical and Health Sciences (251)
Natural sciences (165)
Engineering and Technology (3)
Agricultural Sciences (2)
Social Sciences (2)
Humanities (1)

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