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Numrering	Referens	Omslagsbild	Hitta
1.	Zillikens, M Carola, et al. (författare) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 2017 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1 Tidskriftsartikel (refereegranskat)abstract A correction to this article has been published and is linked from the HTML version of this article.
2.	Corbalan, R, et al. (författare) Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation: A Report From the GARFIELD-AF Registry 2019 Ingår i: JAMA cardiology. - : American Medical Association (AMA). - 2380-6591 .- 2380-6583. ; 4:6, s. 526-548 Tidskriftsartikel (refereegranskat)
3.	Dinh, Thanh Theresa, et al. (författare) The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element 2012 Ingår i: Development. - 0950-1991 .- 1477-9129. ; 139:11, s. 1978-1986 Tidskriftsartikel (refereegranskat)
4.	Yadav, Ram Kishor, et al. (författare) Plant stem cell maintenance involves direct transcriptional repression of differentiation program 2013 Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 9, s. 654-654 Tidskriftsartikel (refereegranskat)abstract In animal systems, master regulatory transcription factors (TFs) mediate stem cell maintenance through a direct transcriptional repression of differentiation promoting TFs. Whether similar mechanisms operate in plants is not known. In plants, shoot apical meristems serve as reservoirs of stem cells that provide cells for all above ground organs. WUSCHEL, a homeodomain TF produced in cells of the niche, migrates into adjacent cells where it specifies stem cells. Through high-resolution genomic analysis, we show that WUSCHEL represses a large number of genes that are expressed in differentiating cells including a group of differentiation promoting TFs involved in leaf development. We show that WUS directly binds to the regulatory regions of differentiation promoting TFs; KANADI1, KANADI2, ASYMMETRICLEAVES2 and YABBY3 to repress their expression. Predictions from a computational model, supported by live imaging, reveal that WUS-mediated repression prevents premature differentiation of stem cell progenitors, being part of a minimal regulatory network for meristem maintenance. Our work shows that direct transcriptional repression of differentiation promoting TFs is an evolutionarily conserved logic for stem cell regulation.
5.	Yadav, Ram Kishor, et al. (författare) WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex 2011 Ingår i: Genes & Development. - : Cold Spring Harbor Laboratory. - 1549-5477 .- 0890-9369. ; 25:19, s. 2025-2030 Tidskriftsartikel (refereegranskat)abstract WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where it activates CLV3 transcription by binding to its promoter elements. Using a computational model, we show that maintenance of the WUS gradient is essential to regulate stem cell number. Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme that is unique to plant stem cell niches.
6.	2017 swepub:Mat__t

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Typ av publikation: tidskriftsartikel (5)

Typ av innehåll: refereegranskat (5)

Författare/redaktör: Chen, X. (2); Endo, M. (2); Hirose, M. (2); Kim, H. (2); Kobayashi, T. (2); Li, L. (2); visa fler...; Liu, B. (2); Nakamura, T. (2); Zhang, R. (2); Suzuki, S (2); Li, J. (2); Kato, Y. (2); Yoshida, T. (2); Kim, J. (2); Wang, Y. (2); Nguyen, T. (2); Mueller, G. (2); Page, A. (2); Lee, S (2); Matsushita, K (2); Yamada, T (2); Abe, S. (2); Yamamoto, T. (2); Ikeda, H. (2); Schmidt, K. (2); Suzuki, K. (2); Abe, M (2); Abe, Y (2); Fukuda, T. (2); Kis, E. (2); Jönsson, Henrik (2); Sharma, M. (2); Jensen, S (2); Hasegawa, K (2); Kelly, S. (2); Yu, H. (2); Fox, B (2); Smith, K. (2); Nakamura, M. (2); Rodriguez, M (2); Singh, B (2); Boda, Z (2); Patel, J (2); Nakamura, R. (2); Sommer, S. (2); Alvarez, M. (2); Connolly, SJ (2); Wolf, T. (2); Volpe, M (2); Goto, S. (2); visa färre...

Lärosäte: Lunds universitet (2); Karolinska Institutet (2); Göteborgs universitet (1); Umeå universitet (1)

Språk: Engelska (6)

Forskningsämne (UKÄ/SCB): Naturvetenskap (2); Medicin och hälsovetenskap (1)

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