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| 2. |
- Axfors, Cathrine, et al.
(författare)
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Association between convalescent plasma treatment and mortality in COVID-19 : a collaborative systematic review and meta-analysis of randomized clinical trials
- 2021
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Ingår i: BMC Infectious Diseases. - : BioMed Central (BMC). - 1471-2334. ; 21:1
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Forskningsöversikt (refereegranskat)abstract
- Background: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, ). Methods: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I-2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.
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| 3. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Winkler, M., et al.
(författare)
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The rich sides of mountain summits - a pan-European view on aspect preferences of alpine plants
- 2016
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Ingår i: Journal of Biogeography. - : Wiley. - 0305-0270. ; 43:11, s. 2261-2273
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Tidskriftsartikel (refereegranskat)abstract
- Aim In the alpine life zone, plant diversity is strongly determined by local topography and microclimate. We assessed the extent to which aspect and its relatedness to temperature affect plant species diversity, and the colonization and disappearance of species on alpine summits on a pan-European scale. Methods Vascular plant species and their percentage cover were recorded in permanent plots in each cardinal direction on 123 summits in 32 regions across Europe. For a subset from 17 regions, resurvey data and 6-year soil temperature series were available. Differences in temperature sum and Shannon index as well as species richness, colonization and disappearance of species among cardinal directions were analysed using linear mixed-effects and generalised mixed-effects models, respectively. Results Temperature sums were higher in east-and south-facing aspects than in the north-facing ones, while the west-facing ones were intermediate; differences were smallest in northern Europe. The patterns of temperature sums among aspects were consistent among years. In temperate regions, thermal differences were reflected by plant diversity, whereas this relationship was weaker or absent on Mediterranean and boreal mountains. Colonization of species was positively related to temperature on Mediterranean and temperate mountains, whereas disappearance of species was not related to temperature. Main conclusions Thermal differences caused by solar radiation determine plant species diversity on temperate mountains. Advantages for plants on eastern slopes may result from the combined effects of a longer diurnal period of radiation due to convection cloud effects in the afternoon and the sheltered position against the prevailing westerly winds. In northern Europe, long summer days and low sun angles can even out differences among aspects. On Mediterranean summits, summer drought may limit species numbers on the warmer slopes. Warmer aspects support a higher number of colonization events. Hence, aspect can be a principal determinant of the pace of climate-induced migration processes.
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| 5. |
- Marganiec, J., et al.
(författare)
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Coulomb Dissociation experiment of 27P
- 2015
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Ingår i: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 46:3, s. 473-476
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Tidskriftsartikel (refereegranskat)abstract
- The 26Si(p; γ)27P reaction, which might play an important role in the rp process, was studied by the Coulomb Dissociation method. The experiment was performed at GSI, Darmstadt. A secondary 27P ion beam of 500 MeV/nucleon was directed onto a Pb target. From this experiment, the Coulomb Dissociation cross section, σCoulex, will be deduced and then converted to the photoabsorption cross section, σphoto, and the radiativecapture cross section, σcap. Also information on the structure of 27P will be obtained. The analysis is in progress.
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| 6. |
- Marganiec, J., et al.
(författare)
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Coulomb dissociation of P-27 at 500 MeV/u
- 2016
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 93:4
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Tidskriftsartikel (refereegranskat)abstract
- The proton-capture reaction Si-26(p,gamma)(27) P was studied via Coulomb dissociation (CD) of P-27 at an incident energy of about 500 MeV/u. The three lowest-lying resonances in P-27 have been populated and their resonance strengths have been measured. In addition, a nonresonant direct-capture component was clearly identified and its astrophysical S factor measured. The experimental results are compared to Monte Carlo simulations of the CD process using a semiclassical model. Our thermonuclear reaction rates show good agreement with the rates from a recent compilation. With respect to the nuclear structure of P-27 we have found evidence for a negative-parity intruder state at 2.88-MeV excitation energy.
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| 8. |
- Beceiro-Novo, S., et al.
(författare)
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Coulomb dissociation of 27 P: A reaction of astrophysical interest
- 2010
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Ingår i: Proceedings of Science. - Trieste, Italy : Sissa Medialab. - 1824-8039. ; 100
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Konferensbidrag (refereegranskat)abstract
- The ground-state decay of 26Al(0+) (T 1/2=1.05× 106) has a shorter life-time than the Universe. The presence of this element in the Galaxy was measured via g-ray spectroscopy, showing that the nucleosynthesis of this element is an ongoing process in stars. The proton-capture reaction 26Si(p,γ) 27P competes with the production of 26Al(0+) by β-decay. Coulomb dissociation of 27P has been suggested as an indirect method to measure radiative-proton capture when the direct reaction is not feasible. Such an experiment was performed at GSI with a secondary 27P beam produced by fragmenting a 36Ar primary beam at 500 A MeV. Two main observables are preliminarily presented in this work: the reaction cross section and the relative-energy spectrum of the outgoing fragments © Copyright owned by the author(s).
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| 9. |
- Giron, S. E., et al.
(författare)
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Increased Central Nervous System Interleukin-8 in a Majority Postlaminectomy Syndrome Chronic Pain Population
- 2018
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Ingår i: Pain Med. ; 19:5, s. 1033-1043
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND OBJECTIVES: Multiple processes have been identified as potential contributors to chronic pain, with increasing evidence illustrating an association with aberrant levels of neuroimmune mediators. The primary objectives of the present study were to examine central nervous system cytokines, chemokines, and growth factors present in a chronic pain population and to explore patterns of the same mediator molecules over time. Secondary objectives explored the relationship of central and peripheral neuroimmune mediators while examining the levels of anxiety, depression, sleep quality, and perception of pain associated with the chronic pain patient experience. METHODS: Cerebrospinal fluid (CSF) from a population of majority postlaminectomy syndrome patients (N = 8) was compared with control CSF samples (N = 30) to assess for significant differences in 10 cytokines, chemokines, and growth factors. The patient population was then followed over time, analyzing CSF, plasma, and psychobehavioral measures. RESULTS: The present observational study is the first to demonstrate increased mean CSF levels of interleukin-8 (IL-8; P < 0.001) in a small population of majority postlaminectomy syndrome patients, as compared with a control population. Over time in pain patients, CSF levels of IL-8 increased significantly (P < 0.001). CONCLUSIONS: These data indicate that IL-8 should be further investigated and psychobehavioral components considered in the overall chronic pain paradigm. Future studies examining the interactions between these factors and IL-8 may identify novel targets for treatment of persistent pain states.
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