| 1. |
- Benussi, Alberto, et al.
(författare)
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Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration.
- 2020
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Ingår i: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 91:9, s. 960-967
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Tidskriftsartikel (refereegranskat)abstract
- To assess the diagnostic and prognostic value of serum neurofilament light (NfL) and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal lobar degeneration (FTLD).In this retrospective study, performed on 417 participants, we analysed serum NfL and p-Tau181 concentrations with an ultrasensitive single molecule array (Simoa) approach. We assessed the diagnostic values of serum biomarkers in the differential diagnosis between FTLD, Alzheimer's disease (AD) and healthy ageing; their role as markers of disease severity assessing the correlation with clinical variables, cross-sectional brain imaging and neurophysiological data; their role as prognostic markers, considering their ability to predict survival probability in FTLD.We observed significantly higher levels of serum NfL in patients with FTLD syndromes, compared with healthy controls, and lower levels of p-Tau181 compared with patients with AD. Serum NfL concentrations showed a high accuracy in discriminating between FTLD and healthy controls (area under the curve (AUC): 0.86, p<0.001), while serum p-Tau181 showed high accuracy in differentiating FTLD from patients with AD (AUC: 0.93, p<0.001). In FTLD, serum NfL levels correlated with measures of cognitive function, disease severity and behavioural disturbances and were associated with frontotemporal atrophy and indirect measures of GABAergic deficit. Moreover, serum NfL concentrations were identified as the best predictors of survival probability.The assessment of serum NfL and p-Tau181 may provide a comprehensive view of FTLD, aiding in the differential diagnosis, in staging disease severity and in defining survival probability.
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| 2. |
- Benussi, Alberto, et al.
(författare)
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Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar Degeneration.
- 2020
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Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 77:3, s. 1129-1141
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Tidskriftsartikel (refereegranskat)abstract
- It is still unknown if serum glial fibrillary acidic protein (GFAP) is a useful marker in frontotemporal lobar degeneration (FTLD).To assess the diagnostic and prognostic value of serum GFAP in a large cohort of patients with FTLD.In this retrospective study, performed on 406 participants, we measured serum GFAP concentration with an ultrasensitive Single molecule array (Simoa) method in patients with FTLD, Alzheimer's disease (AD), and in cognitively unimpaired elderly controls. We assessed the role of GFAP as marker of disease severity by analyzing the correlation with clinical variables, neurophysiological data, and cross-sectional brain imaging. Moreover, we evaluated the role of serum GFAP as a prognostic marker of disease survival.We observed significantly higher levels of serum GFAP in patients with FTLD syndromes, except progressive supranuclear palsy, compared with healthy controls, but not compared with AD patients. In FTLD, serum GFAP levels correlated with measures of cognitive dysfunction and disease severity, and were associated with indirect measures of GABAergic deficit. Serum GFAP concentration was not a significant predictor of survival.Serum GFAP is increased in FTLD, correlates with cognition and GABAergic deficits, and thus shows promise as a biomarker of disease severity in FTLD.
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| 3. |
- Deshapriya, Jasinghege Don Prasanna, et al.
(författare)
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Clustering the properties of near-Earth objects : physico-dynamical links among NEOs
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 674
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Tidskriftsartikel (refereegranskat)abstract
- Context. At present, near-Earth objects (NEOs) are being discovered at an ever-increasing rate. However, their physical characterisation is still significantly lagging behind. In particular, the taxonomic classification of newly discovered NEOs is of great importance with regard to improving our understanding of the population of NEOs.Aims. In this context, our goal is to probe potential links between orbital properties of NEOs and their composition. We investigate whether we can make a reasonable guess about the taxonomic class of an NEO upon its discovery with a decent orbital accuracy.Methods. We used a G-mode multivariate statistical clustering method to find homogeneous clusters in a dataset composed of orbital elements of NEOs. We adopted two approaches, using two sets of variables as inputs to the G-mode method. In each approach, we analysed the available taxonomic distribution of resulting clusters to find potential correlations with several unique parameters that distinctively characterise NEOs. We then applied a dynamical model on the same clusters to trace their escape regions.Results. Approach 1 (A1) led us to obtain NEO clusters that can be linked to a primitive composition. This result was further strengthened by the dynamical model, which mapped outer-belt sources as escape regions for these clusters. We remark on the finding of a cluster akin to S-type NEOs in highly eccentric orbits during the same approach (A1). Two clusters, one with small NEOs in terrestriallike orbits and one with relatively high inclinations, were found to be common to both approaches. Approach 2 (A2) revealed three clusters that are only separable by their arguments of perihelion. Taken altogether, they make up the majority of known Atira asteroids.Conclusions. For an NEO whose orbit is relatively well determined, we propose a model to determine whether the taxonomy of an NEO is siliceous or primitive if the orbital elements of the NEO fall within the presented combinations of inclination, eccentricity, and semi-major axis ranges.
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