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- Holland, John, et al.
(författare)
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Meeting the challenge of wild deer research to support delivery of sustainable deer management in Scotland
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this project was to analyse existing wild deer research and identify specific research and evidence gaps which need to be addressed in order to meet the challenges for each of the five priorities outlined in Scotland’s Wild Deer - A National Approach (WDNA).The project was developed to facilitate more effective exchange of knowledge and provide a fuller understanding of the issues involved in deer management and therefore help deliver targeted, informed and sustainable deer management in Scotland. This report complements the recently published Deer Management in Scotland: Report to the Scottish Government from Scottish Natural Heritage 2016.Gaps in the existing knowledge-base were identified by gathering the views of stakeholders at a series of workshops, through an online survey of researchers and policy makers, and through a review of published and un-published research material. Workshops were run across Scotland, including four regional stakeholder workshops, one workshop for trainers,and one for researchers/policy makers. The uptake of research by stakeholders was also examined through the use of an on-line survey of researchers and policy makers. The information gained from the workshops, online survey and literature review were analysed to determine the key research and knowledge transfer gaps associated with each of the five WDNA priorities.As part of the project a web-based deer research resource was created that provides an online database of deer research relevant to the five WDNA priorities (www.deerscotland.info).
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- Scott, Alister, et al.
(författare)
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UK National Ecosystem Assessment Follow-on : Work Package Report 10: Tools, Applications, Benefits and Linkages for Ecosystem Science (TABLES)
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Over an 18 month period, the Tools: Applications, Benefits and Linkages for Ecosystems (TABLES) project has worked at the interface of research, policy and practice, crossing different disciplines, sectors and professions, to embed the value of nature more effectively into policies, programmes, plans or projects and thus improve decision -making processes and outcomes.Our main focus has been on translating the 12 principles of the Ecosystem Approach into comprehensive advice within which a set of tools can utilise an Ecosystem Services Framework . The interdisciplinary TABLES team, consisting of academics, professionals in practice, community members and policy makers, championed co-production and social learning strategies using member expertise and experience within diverse case studies. These span the environment, business, local community and planning sectors; all of which are trying to mainstream an Ecosystem Approach to some extent.The project addresses the recommendations of the UK National Ecosystem Assessment (UK NEA, 2011a, 1303) to integrate ecosystem services and the wider values of the natural environment within a context of policy and decision-making and tools leading to a superior basis for future decision-making.
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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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- Hörlein, A. J., et al.
(författare)
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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
- 1995
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 377:6548, s. 397-404
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Tidskriftsartikel (refereegranskat)abstract
- Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
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- ILAG, LL, et al.
(författare)
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Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo
- 1995
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:2, s. 607-611
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Tidskriftsartikel (refereegranskat)abstract
- Pan-neurotrophin 1 (PNT-1) is a synthetic trophic factor engineered by combining active domains of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) into an NT-3 backbone. This molecule was produced in transiently transfected COS cells or in baculovirus-infected insect cells transfected COS cells or in baculovirus-infected insect cells and subsequently purified to homogeneity. Saturation binding in embryonic spinal sensory neurons demonstrated a greater number of high-affinity binding sites for PNT-1 than for its parental molecule NT-3. PNT-1 was shown to efficiently block the chemical crosslinking of NGF, BDNF, and NT-3 to their cognate Trk receptors and to the low-affintiy NGF receptor expressed on neuronal and nonneuronal cells. PNT-1 stimulated survival and proliferation of MG87 fibroblasts expressing either TrkA, TrkB, or TrkC. PNT-1 also promoted survival of a greater number of embryonic dorsal root ganglion neurons than any of the other neurotrophins alone, and its effects were equivalent to a combination of NGF, BDNF, and NT-3. Analysis of receptor-specific neurotrophic activities demonstrated that PNT-1 efficiently rescued TrkA mRNA-containing sympathetic neurons and TrkB and TrkC mRNA-containing sensory neurons from the dorsal root and nodose ganglia. Finally, PNT-1 showed robust retrograde transport to DRG neurons in vivo after injection into the sciatic nerve. Radiolabeled PNT-1 accumulated in small-, medium-, and large-sized neurons. Coinjection with different unlabeled neurotrophins inhibited PNT-1 transport in distinct subpopulations of neurons of different sizes, suggesting that this molecule affects sensory neurons of different modalities. These results indicate that PNT-1 is a potent and multispecific neurotrophic factor that may be useful in the treatment of peripheral neurophathies and nerve damage.
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| 10. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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