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- Glaumann, S., et al.
(författare)
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Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children
- 2012
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Ingår i: Allergy: European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 67:2, s. 242-247
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Tidskriftsartikel (refereegranskat)abstract
- Background: Immunoglobulin E (IgE)-sensitization to peanut is common and can indicate an allergy. A positive test needs to be confirmed by a double-blind, placebo-controlled food challenge (DBPCFC), which is regarded as 'the gold standard'. The aim of the study was to evaluate the basophil allergen threshold sensitivity (CD-sens) and antibodies to peanut allergen components in relation to DBPCFC in the diagnoses of peanut allergy in children. Methods: Thirty-eight children with suspected peanut allergy underwent a DBPCFC. CD-sens to peanut and Ara h 2 were analysed as well as IgE-antibody to peanut and some of its allergen components (Ara h 1, 2, 3, 8 and 9). Results: Twenty-five children had a positive DBPCFC, and 92% of these were positive in CD-sens to peanut and Ara h 2. Two children with a positive DBPCFC were classified as 'low-responders' and were not further evaluated. Children positive in DBPCFC had higher CD-sens values to peanut (median 1.3; range 0.4-29, n = 21) compared with children negative in DBPCFC (median 0; range 0-0.5, n = 13) (P < 0.0001). A positive DBPCFC correspond with increased levels of IgE-antibody to Ara h 1, 2 and 3 compared with those with a negative challenge (P < 0.0001 for all). All children with a negative CD-sens were negative in DBPCFC. Conclusion: In this study, a negative CD-sens to peanut excluded peanut allergy. Both tests, CD-sens to peanut and immunoassay for IgE-antibody to the peanut components, appear to be safe, time saving and cost-effective complements to DBPCFC. © 2011 John Wiley & Sons A/S.
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- Glaumann, S., et al.
(författare)
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Oral Peanut Challenge Identifies an Allergy but the Peanut Allergen Threshold Sensitivity Is Not Reproducible
- 2013
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Double-blind placebo-controlled food challenge, DBPCFC, the gold standard for Objectives: To evaluate the reproducibility of oral peanut challenge and compare the outcome to CD- Methods: Twenty-seven children (4-19 years) underwent a DBPCFC followed by a single-blind oral Results: Thirteen children (48%) did not react at any of the challenges. Fourteen reacted at both peanut Conclusions: For a positive/negative test the reproducibility is 100% for both peanut challenge and CD-sens. However, a comparison of the degree of allergen threshold sensitivity between the two tests is not possible since the threshold dose and severity scoring is not reproducible.
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| 7. |
- Svenfelt, Åsa, PhD, Docent, 1968-, et al.
(författare)
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Miljöklassning av byggnader : Inventering av metoder och intressenters behov
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport innehåller resultatet av projektets inledningsfas, kapitel 2 är en genomgång av politiska och andra mål för hållbar utveckling inom området byggnader med syfte att sätta miljöklassningssystemet i ett sammanhang, kapitel 3 är en redovisning av hur inledningsfasen genomförts, kapitel 4 innehåller resultatet av intervjuer med företag inom bygg och fastighetsbranschen om deras inställning till ett miljöklassningsystem samt intervjuer med aktörer som potentiellt kan skapa incitament för att företag och fastighetsägare ska ansluta sig till miljöklassningssystemet, kapitel 5 behandlar översiktligt genomgången av befintliga metoder för miljöbedömning av byggnader, kapitel 6 redovisar utgångspunkter för det fortsatta arbetet med ett miljöklassningsystem, kapitel 7 innehåller diskussion och slutsatser. Befintliga metoder för miljöbedömning av byggnader redovisas som informationsblad i bilaga 7 (svenska) och bilaga 10 (utländska).
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- Asarnoj, A, et al.
(författare)
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Anaphylaxis to peanut in a patient predominantly sensitized to Ara h 6
- 2012
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Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 159:2, s. 209-212
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Tidskriftsartikel (refereegranskat)abstract
- Diagnosis of peanut allergy has improved thanks to component-resolved diagnostics. Peanut allergen component Ara h 2 is considered to indicate true peanut allergy. The component Ara h 6 is structurally similar to Ara h 2, but the diagnostic value of analyzing IgE antibodies to Ara h 6 is unclear. A boy sensitized (≥0.35 kU<sub>A</sub>/l) to Ara h 8 but not to Ara h 1, Ara h 2 and Ara h 3 was challenged with peanut and developed grade II anaphylaxis. In serum collected at the time of challenge a doubling of IgE to the peanut allergen extract was observed compared to allergy testing 9 months earlier. In contrast, IgE levels to Ara h 1, Ara h 2, Ara h 3 and to Ara h 8 were rather unchanged. After another 2 months, Ara h 6 was analyzed and revealed a level of 24 kU<sub>A</sub>/l whilst Ara h 2 was 0.12 kU<sub>A</sub>/l. We suggest that IgE sensitization to Ara h 6 caused the reaction and conclude that analyses of IgE levels to peanut and peanut components should be performed in connection with a challenge. Furthermore, levels to Ara h 2 below 0.35 kU<sub>A</sub>/l may still indicate a risk of severe reaction at the time of challenge since in rare cases, Ara h 6 IgE antibodies may be present without occurrence of IgE antibodies to Ara h 2.
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