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- Døssing, A., et al.
(författare)
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A Multidisciplinary UAV- and Ground-Geophysical Mapping of Complex Mineralisations in an Inter-Tidal Coastal Zone, Brittany (France)
- 2020
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Ingår i: NSG2020 3rd Conference on Geophysics for Mineral Exploration and Mining. - : European Association of Geoscientists and Engineers.
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Konferensbidrag (refereegranskat)abstract
- Getting reliable geophysical and geological 3D models of the subsurface is an absolute necessity for successful resources exploration. Here, we show how novel UAV-borne geophysical mapping can be extremely valuable for mapping potential new exploration areas that are difficult to access by foot, such as hard rock inter-tidal zones and boulder beaches. We show the results from a multidisciplinary geophysical campaign of highly magnetic dikes and granites along a boulder beach in Brittany, France. Our mapping is carried out using customized geophysical sensor systems with high quality sensors. These include in particular a special designed UAV-towed magnetometer bird and multispectral system for large area mapping purposes. The UAV-borne mapping is supplemented by ground-based gamma-ray spectrometry data and ground-based magnetic gradiomety data. The results clearly demonstrate the value of UAV-borne systems in difficult areas as compared to traditional mapping methods as well as the value of combining various geophysical sensors for exploring the economic geology. All UAV-borne data were collected during two days, while the ground-based data – covering only the inner and dry part of the beach - were collected over seven days.
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| 2. |
- Guintivano, Jerry, et al.
(författare)
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Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
- 2023
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Ingår i: American Journal of Psychiatry. - : American Psychiatric Association Publishing. - 0002-953X .- 1535-7228. ; 180:12, s. 884-895
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.METHOD: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS findings in 27 human tissues and 265 cell types from the mouse central and peripheral nervous system.RESULTS: No SNP achieved genome-wide significance in the European or the trans-ancestry meta-analyses. The [Formula: see text] of PPD was 0.14 (SE=0.02). Significant genetic correlations were estimated for PPD with MDD, bipolar disorder, anxiety disorders, posttraumatic stress disorder, insomnia, age at menarche, and polycystic ovary syndrome. Cell-type enrichment analyses implicate inhibitory neurons in the thalamus and cholinergic neurons within septal nuclei of the hypothalamus, a pattern that differs from MDD.CONCLUSIONS: While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
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