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Sökning: WFRF:(Gnesin Silvano)

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1.
  • Cicone, Francesco, et al. (författare)
  • The contest between internal and external-beam dosimetry : The Zeno's paradox of Achilles and the tortoise
  • 2023
  • Ingår i: Physica Medica. - 1120-1797.
  • Forskningsöversikt (refereegranskat)abstract
    • Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course. The efficacy and the toxicity of both types of treatment rely on the interaction of radiation with biological tissues. Dosimetry played a fundamental role in the scientific and technological evolution of EBRT, and absorbed doses to the target and to the organs at risk are calculated on a routine basis. In contrast, in MRT the usefulness of internal dosimetry has long been questioned, and a structured path to include absorbed dose calculation is missing. However, following a similar route of development as EBRT, MRT treatments could probably be optimized in a significant proportion of patients, likely based on dosimetry and radiobiology. In the present paper we describe the differences and the similarities between internal and external-beam dosimetry in the context of radiation treatments, and we retrace the main stages of their development over the last decades.
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2.
  • Gear, Jonathan, et al. (författare)
  • EANM enabling guide : how to improve the accessibility of clinical dosimetry
  • 2023
  • Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer. - 1619-7070 .- 1619-7089. ; 50, s. 1861-1868
  • Tidskriftsartikel (refereegranskat)abstract
    • Dosimetry can be a useful tool for personalization of molecular radiotherapy (MRT) procedures, enabling the continuous development of theranostic concepts. However, the additional resource requirements are often seen as a barrier to implementation. This guide discusses the requirements for dosimetry and demonstrates how a dosimetry regimen can be tailored to the available facilities of a centre. The aim is to help centres wishing to initiate a dosimetry service but may not have the experience or resources of some of the more established therapy and dosimetry centres. The multidisciplinary approach and different personnel requirements are discussed and key equipment reviewed example protocols demonstrating these factors are given in the supplementary material for the main therapies carried out in nuclear medicine, including [I-131]-NaI for benign thyroid disorders, [Lu-177]-DOTATATE and I-131-mIBG for neuroendocrine tumours and [Y-90]-microspheres for unresectable hepatic carcinoma.
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