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- Elavsky, Steriani, et al.
(författare)
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Behavioral correlates of depressive symptoms in older unlike-sex twin-pairs
- 2013
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Ingår i: Aging Clinical and Experimental Research. - : Springer Science and Business Media LLC. - 1594-0667 .- 1720-8319. ; 25:3, s. 257-264
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: This study examines gender-specific behavioral correlates of depressive symptoms using a secondary data analysis of a cross-sectional, population-based sample of older unlike-sex twins.Methods: Unlike-sex twins aged 69–88 were identified through a national Swedish registry and sent a survey about health, including depressive symptoms (CES-D) and the frequency of engaging in physical, social and mental activities. A total of 605 complete twin pairs responded.Results: Depressive symptom scores were associated with frequency of engagement in physical and mental activities, but only in men. No statistically significant associations with depressive symptom scores for any of the three types of activities were found in women.Conclusions: The results suggest that engaging in physical and mental activities may protect older men from developing depressive symptoms, but longitudinal data are needed to offer more conclusive findings on the role that physical, mental, and social activities play in the maintenance of psychological health in older men and women.
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| 3. |
- Gold, Carol, et al.
(författare)
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Gender and patterns of cardiovascular diagnoses in an unlike-sex twin sample in Sweden
- 2007
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Ingår i: The Gerontological Society of America, 60th Annual Scientific Meeting, San Francisco. ; , s. 68-
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Konferensbidrag (refereegranskat)abstract
- Gender and Patterns of Cardiovascular Diagnoses and Year of Diagnoses in an Unlike-Sex Twin Sample in Sweden Cardiovascular disease is the number one cause of death for men and women. This study examined diagnoses in health records in a sample of older-unlike-sex twins in Sweden (N=249 pairs). A physician in Sweden has examined these twins’ medical records going back as far as 50 years and compiled a database with diagnoses based on ICD-10 codes and the year of diagnosis. A subsample of twinpairs was created in which both members had been diagnosed with at least one cardiovascular condition (N=140 pairs). The number of these conditions ranged from 1-8, with men having more than women (chi-square = 15.349, 7 d.f., p<.05). Analyses of the 4 most frequent conditions were conducted. We found 59 subjects with a diagnosis of myocardial infarction (45 men; 14 women), but only 4 concordant twinpairs; of those 2 brothers preceded their sister in year of diagnosis. We found 72 cases of congestive heart failure (43 men; 29 women), but only 12 concordant twinpairs; in half of those cases, the brother preceded his sister. We found 61 cases of stroke (34 men; 27 women), but only 12 concordant twinpairs; in 5 cases the brother preceded his sister. We found 181 subjects with arterial hypertension (77 men; 104 women), and 66 concordant twinpairs; in 31 of those twinpairs, the brother preceded his sister, and in 35 the sister preceded her brother. Additional pattern analyses will be presented that describe the arrays of cardiovascular co-morbidities and their year of diagnosis within twinpairs and the whole sample. Benefits and Learning Objectives To present pattern analyses of cardiovascular conditions in an unlike-sex twin sample
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| 5. |
- Kirchhoff, Tomas, et al.
(författare)
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Breast cancer risk and 6q22.33 : combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
- 2012
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Ingår i: PLOS ONE. - : Public library of science. - 1932-6203. ; 7:6
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
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