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1.	Joshi, Sameer M., et al. (author) Synthesis of radiolabelled aryl azides from diazonium salts: experimental and computational results permit the identification of the preferred mechanism 2015 In: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 51:43, s. 8954-8957 Journal article (peer-reviewed)abstract Experimental and computational studies on the formation of aryl azides from the corresponding diazonium salts support a stepwise mechanism via acyclic zwitterionic intermediates. The low energy barriers associated with both transition structures are compatible with very fast and efficient processes, thus making this method suitable for the chemical synthesis of radiolabelled aryl azides.
2.	Koziorowski, Jacek, et al. (author) Radiolabeled Nanoparticles for Cancer Diagnosis and Therapy 2017 In: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. - : BENTHAM SCIENCE PUBL LTD. - 1871-5206. ; 17:3, s. 333-354 Research review (peer-reviewed)abstract Cancer remains as one of the major causes of death worldwide. The emergence of nanotechnology has opened new avenues for the development of nanoparticle (NP)-based diagnostic and therapeutic tools. NPs of different chemical composition, size, shape and surface decoration can be prepared using a wide variety of synthetic strategies. Subsequent radiolabelling with positron or gamma emitters results in potential diagnostic agents which may offer improved selectivity and/or specificity for the target organ or tissue, enabling the acquisition of images with higher signal-to-contrast ratio. Incorporation of alpha or beta emitters leads to therapeutic agents with application in the field of radiotherapy. Here, we first describe the different labeling strategies reported so far for the incorporation of radionuclides into NPs. Recent advances in the use of nanoparticulate constructs both in the diagnostic and therapeutic arenas are then discussed and examples of their application are briefly discussed.

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Type of publication: journal article (1); research review (1)

Type of content: peer-reviewed (2)

Author/Editor: Koziorowski, Jacek (2); Llop, Jordi (2); Gomez-Vallejo, Vanes ... (2); Joshi, Sameer M. (1); de Cozar, Abel (1); Cossio, Fernando P. (1); show more...; Stanciu, Adina E. (1); show less...

University: Linköping University (2)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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