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- Chachoua, I, et al.
(författare)
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Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 204-
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Tidskriftsartikel (refereegranskat)abstract
- Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood process. We show here that the principal tenet of the WNT-regulated MYC gating, facilitating nuclear export of the MYC mRNA, is regulated by a CTCF binding site (CTCFBS) within the OSE to confer growth advantage in HCT-116 cells. To achieve this, the CTCFBS directs the WNT-dependent trafficking of the OSE to the nuclear pore from intra-nucleoplasmic positions in a stepwise manner. Once the OSE reaches a peripheral position, which is triggered by a CTCFBS-mediated CCAT1 eRNA activation, its final stretch (≤0.7 μm) to the nuclear pore requires the recruitment of AHCTF1, a key nucleoporin, to the CTCFBS. Thus, a WNT/ß-catenin-AHCTF1-CTCF-eRNA circuit enables the OSE to promote pathological cell growth by coordinating the trafficking of the active MYC gene within the 3D nuclear architecture.
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- de Lima, CDM, et al.
(författare)
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Circadian organization of the genome
- 2018
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 359:6381, s. 1212-1213
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Tidskriftsartikel (refereegranskat)abstract
- The clock protein Rev-erbα regulates genome folding to establish circadian gene repression
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- Gondor, A, et al.
(författare)
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Chromosome crosstalk in three dimensions
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 461:7261, s. 212-217
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Tidskriftsartikel (refereegranskat)
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