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- Thoma, B, et al.
(författare)
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An international, interprofessional investigation of the self-reported podcast listening habits of emergency clinicians: A METRIQ Study
- 2020
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Ingår i: CJEM. - : Springer Science and Business Media LLC. - 1481-8043 .- 1481-8035. ; 22:1, s. 112-117
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesPodcasts are increasingly being used for medical education. A deeper understanding of usage patterns would inform both producers and researchers of medical podcasts. We aimed to determine how and why podcasts are used by emergency medicine and critical care clinicians.MethodsAn international interprofessional sample (medical students, residents, physicians, nurses, physician assistants, and paramedics) was recruited through direct contact and a multimodal social media (Twitter and Facebook) campaign. Each participant completed a survey outlining how and why they utilize medical podcasts. Recruitment materials included an infographic and study website.Results390 participants from 33 countries and 4 professions (medicine, nursing, paramedicine, physician assistant) completed the survey. Participants most frequently listened to medical podcasts to review new literature (75.8%), learn core material (75.1%), and refresh memory (71.8%). The majority (62.6%) were aware of the ability to listen at increased speeds, but most (76.9%) listened at 1.0 x (normal) speed. All but 25 (6.4%) participants concurrently performed other tasks while listening. Driving (72.3%), exercising (39.7%), and completing chores (39.2%) were the most common. A minority of participants used active learning techniques such as pausing, rewinding, and replaying segments of the podcast. Very few listened to podcasts multiple times.ConclusionsAn international cohort of emergency clinicians use medical podcasts predominantly for learning. Their listening habits (rarely employing active learning strategies and frequently performing concurrent tasks) may not support this goal. Further exploration of the impact of these activities on learning from podcasts is warranted.
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- Haiman, Christopher A., et al.
(författare)
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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
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Tidskriftsartikel (refereegranskat)abstract
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
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- Purrington, Kristen S., et al.
(författare)
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Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
- 2014
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 35:5, s. 1012-1019
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Tidskriftsartikel (refereegranskat)abstract
- In a genome-wide scan, we show that 30 variants in 25 genomic regions are associated with risk of TN breast cancer. Women carrying many of the risk variants may have 4-fold increased risk relative to women with few variants.Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P < 5 x 10(-) (8)) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P < 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P < 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 x 10(-) (4)] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 x 10(-) (9)) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95% confidence interval 3.46-4.70, P = 4.8 x 10(-) (69)). This translates to an absolute risk for TN breast cancer ranging from 0.8% to 3.4%, suggesting that genetic variation may be used for TN breast cancer risk prediction.
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| 6. |
- Hall, Adrian M., et al.
(författare)
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Glacial ripping: geomorphological evidence from Sweden for a new process of glacial erosion
- 2020
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Ingår i: Geografiska Annaler Series a-Physical Geography. - : Informa UK Limited. - 0435-3676 .- 1468-0459. ; 2:4, s. 333-53
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Tidskriftsartikel (refereegranskat)abstract
- In low relief Precambrian gneiss terrain in eastern Sweden, abraded bedrock surfaces were ripped apart by the Fennoscandian Ice Sheet. The resultantboulder spreadsare covers of large, angular boulders, many with glacial transport distances of 1-100 m. Boulder spreads occur alongside partly disintegrated roches moutonnees and associated fracture caves, and are associated withdisrupted bedrock, which shows extensive fracture dilation in the near surface. These features are distributed in ice-flow parallel belts up to 10 km wide and extend over distances of >500 km. Our hypothesis is that the assemblage results from (1) hydraulic jacking and bedrock disruption, (2) subglacial ripping and (3) displacement, transport and final deposition of boulders. Soft sediment fills indicate jacking and dilation of pre-existing bedrock fractures by groundwater overpressure below the ice sheet. Overpressure reduces frictional resistance along fractures. Where ice traction overcomes this resistance, the rock mass strength is exceeded, resulting in disintegration of rock surfaces and ripping apart into separate blocks. Further movement and deposition create boulder spreads and moraines. Short boulder transport distances and high angularity indicate that glacial ripping operated late in the last deglaciation. The depths of rock mobilized in boulder spreads are estimated as 1-4 m. This compares with 0.6-1.6 m depths of erosion during the last glaciation derived from cosmogenic nuclide inventories of samples from bedrock surfaces without evidence of disruption. Glacially disrupted and ripped bedrock is also made ready for removal by future ice sheets. Henceglacial rippingis a highly effective process of glacial erosion.
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- Jansson, Krister, et al.
(författare)
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Using a GIS filtering approach to replicate patterns of glacial erosion
- 2011
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Ingår i: Earth Surface Processes and Landforms. - : Wiley. - 0197-9337 .- 1096-9837. ; 36:3, s. 408-418
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Tidskriftsartikel (refereegranskat)abstract
- In order to extend our knowledge of glacial relief production in mountainous areas new methods are required for landscape reconstructions on a temporal resolution of a glacial cycle and a spatial resolution that includes the most important terrain components. A generic data set and a 50 m resolution digital elevation model over a study area in northern Sweden and Norway (the present day landscape data set) were employed to portray spatial patterns of erosion by reconstructing the landscape over successive cycles of glacial erosion. A maximum-value geographic information system (GIS) filtering technique using variable neighbourhoods was applied such that existing highpoints in the landscape were used as erosional anchor points for the reconstruction of past landscape topography. An inherent assumption, therefore, is that the highest surfaces have experienced insignificant down-wearing over the Quaternary. Over multiple reconstruction cycles, proceeding backwards in time, the highest summits increase in area, valleys become shallower, and the valley pattern becomes increasingly simplified as large valleys become in-filled from the sides. The sum of these changes reduces relief. The pattern of glacial erosion, which is to 60% correlated to slope angle and to 70% correlated to relative relief, is characterized by (i) an abrupt erosional boundary below preserved summit areas, (ii) enhanced erosion in narrow valleys, (iii) restricted erosion of smooth areas, independently of elevation, (iv) eradication of small-scale irregularities, (v) restricted erosion on isolated hills in low-relief terrain, and (vi) a valley widening independent of valley directions. The method outlined in this paper shows how basic GIS filtering techniques can mimic some of the observed patterns of glacial erosion and thereby help deduce the key controls on the processes that govern large-scale landscape evolution beneath ice sheets.
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| 8. |
- Moon, S., et al.
(författare)
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Present-Day Stress Field Influences Bedrock Fracture Openness Deep Into the Subsurface
- 2020
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 47:23
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Tidskriftsartikel (refereegranskat)abstract
- Fracturing of bedrock promotes water-rock interactions and influences the formation of the life-sustaining layer of soil at Earth's surface. Models predict that present-day stress fields should influence bedrock fracture openness, but testing this prediction has proven difficult because comprehensive fracture data sets are rarely available. We model the three-dimensional present-day stress field beneath the deglaciated, low-relief landscape of Forsmark, Sweden. We account for ambient regional stresses, pore pressure, topography, sediment weight, and seawater loading. We then compare the modeled stresses to a data set of similar to 50,000 fractures reaching depths of 600 m at Forsmark. We show that modeled failure proxies correlate strongly with the fraction of observed open fractures to depths of similar to 500 m. This result implies that the present-day regional stress field, affected by surface conditions and pore pressure, influences fracture openness in bedrock hundreds of meters beneath the surface, thereby preparing the rock for further weathering. Plain Language Summary The "critical zone"-the life-sustaining part of the Earth that extends from the top of the tree canopy to the bottom of permeable bedrock-is essential for ecosystems and agriculture. The opening of bedrock fractures and onset of water-rock interaction are crucial to the formation of the critical zone. Within the bedrock, the intensities of horizontal regional forces and vertical gravitational forces typically increase with depth. These force intensities, or stresses, are modified by surface effects associated with topography, the weight of overlying seawater and sediment, and by groundwater pressure. However, the influence of these surface effects on fractures has been difficult to observe because comprehensive fracture data sets are rare. In this study, we examine whether, and to what depths, bedrock may fracture under the influence of stress associated with surficial conditions. We compare bedrock stress calculations with similar to 50,000 fractures from 18 cores reaching depths of 600 m at Forsmark, Sweden. We find that the present-day stress field influences the opening of fractures to depths of 500 m, contributing to the formation of the critical zone and the preparation of rock for weathering hundreds of meters beneath the surface, much deeper than previously thought.
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