| 1. |
- Daranciang, Dan, et al.
(författare)
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Ultrafast Photovoltaic Response in Ferroelectric Nanolayers
- 2012
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Ingår i: Physical Review Letters. - 1079-7114. ; 108:8
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Tidskriftsartikel (refereegranskat)abstract
- We show that light drives large-amplitude structural changes in thin films of the prototypical ferroelectric PbTiO3 via direct coupling to its intrinsic photovoltaic response. Using time-resolved x-ray scattering to visualize atomic displacements on femtosecond time scales, photoinduced changes in the unit-cell tetragonality are observed. These are driven by the motion of photogenerated free charges within the ferroelectric and can be simply explained by a model including both shift and screening currents, associated with the displacement of electrons first antiparallel to and then parallel to the ferroelectric polarization direction.
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| 2. |
- Haiman, Christopher A., et al.
(författare)
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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
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Tidskriftsartikel (refereegranskat)abstract
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
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| 3. |
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| 4. |
- Regnéll, Joachim, 1956-, et al.
(författare)
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Ice-dammed lakes of Scandinavia : A key to the pattern and chronology of the final decay of the Scandinavian ice-sheet
- 2021
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Here we present the use of ice-dammed lake-related landforms and sediments for reconstructing the final phases of decay of the Scandinavian Ice Sheet.In the late stages of the deglaciation, extensive glacial lakes were dammed between the easterly retreating Scandinavian Ice Sheet and the water divide within the mountains to the west. Using high-resolution airborne LiDAR-data, shorelines and other landforms relating to these ice-dammed lakes have now been discovered over larger areas and in greater numbers than previously known, opening a treasure trove of palaeoglaciological information of vast potential for reconstructing the final decay phase of the Scandinavian Ice Sheet.The geomorphological imprint of the ice-dammed lakes is of particular importance in northern Scandinavia, as geological evidence pertaining unequivocally to the final ice sheet decay is sparse. Its interpretation is complicated since the ice sheet is thought to have mainly been cold-based during final decay, inhibiting sliding at the ice-bed interface and limiting the construction (or destruction) of landforms indicative of the changing shape and flow of the ice sheet. Furthermore, dated sediment sequences marking the onset of ice-free conditions are woefully few in northern Scandinavia. Likewise, available cosmogenic nuclide exposure dates provide high age uncertainty and inadequate geographical cover, leaving the timing and location of final ice sheet decay still elusive.Using examples from northern and central Scandinavia, we show that ice-dammed lakes are an intricate part of the deglacial dynamics and show how mapping and dating them offer a solution to these problems. Even with a frozen ice-bed interface, surface melting and meltwater drainage creates landforms unequivocally associated with ice sheet decay: drainage channels, dammed lake shorelines, and deltas. Meltwater drainage routes and ice-dammed lakes are therefore powerful tools for reconstructing a disintegrating ice sheet; a ponded lake reveals the location of its requisite ice-dam, and drainage pathways reveal ice-free conditions. A dated sequence of ice-dammed lake sediments can therefore constrain both ice and lake coverage at that time for a much larger area than the dated site itself. Furthermore, the extent of different ice-dammed lake stages and their requisite ice-damming positions enables the pattern of ice margin change to be traced, and the relative age of ice-marginal positions determined using cross-cutting relations. The shorelines’ present-day tilts are also used to inform patterns and magnitudes of postglacial isostatic uplift, information otherwise lacking from the continental interior but of particular importance for modelling former ice sheet volumes and understanding the crustal response to ice sheet loading. Reconstructing the extents and timing of ice-dammed lakes and the study of related landforms and deposits can therefore greatly improve our understanding of the final decay of the Scandinavian Ice Sheet and provide potential analogues for the predicted future behaviours of modern ice sheets.
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| 5. |
- Regnéll, Joachim, et al.
(författare)
-
Ice-dammed lakes of Scandinavia : A key to the pattern and chronology of the final decay of the Scandinavian ice-sheet
- 2021
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Here we present the use of ice-dammed lake-related landforms and sediments for reconstructing the final phases of decay of the Scandinavian Ice Sheet. In the late stages of the deglaciation, extensive glacial lakes were dammed between the easterly retreating Scandinavian Ice Sheet and the water divide within the mountains to the west. Using high-resolution airborne LiDAR-data, shorelines and other landforms relating to these ice-dammed lakes have now been discovered over larger areas and in greater numbers than previously known, opening a treasure trove of palaeoglaciological information of vast potential for reconstructing the final decay phase of the Scandinavian Ice Sheet. The geomorphological imprint of the ice-dammed lakes is of particular importance in northern Scandinavia, as geological evidence pertaining unequivocally to the final ice sheet decay is sparse. Its interpretation is complicated since the ice sheet is thought to have mainly been cold-based during final decay, inhibiting sliding at the ice-bed interface and limiting the construction (or destruction) of landforms indicative of the changing shape and flow of the ice sheet. Furthermore, dated sediment sequences marking the onset of ice-free conditions are woefully few in northern Scandinavia. Likewise, available cosmogenic nuclide exposure dates provide high age uncertainty and inadequate geographical cover, leaving the timing and location of final ice sheet decay still elusive. Using examples from northern and central Scandinavia, we show that ice-dammed lakes are an intricate part of the deglacial dynamics and show how mapping and dating them offer a solution to these problems. Even with a frozen ice-bed interface, surface melting and meltwater drainage creates landforms unequivocally associated with ice sheet decay: drainage channels, dammed lake shorelines, and deltas. Meltwater drainage routes and ice-dammed lakes are therefore powerful tools for reconstructing a disintegrating ice sheet; a ponded lake reveals the location of its requisite ice-dam, and drainage pathways reveal ice-free conditions. A dated sequence of ice-dammed lake sediments can therefore constrain both ice and lake coverage at that time for a much larger area than the dated site itself. Furthermore, the extent of different ice-dammed lake stages and their requisite ice-damming positions enables the pattern of ice margin change to be traced, and the relative age of ice-marginal positions determined using cross-cutting relations. The shorelines’ present-day tilts are also used to inform patterns and magnitudes of postglacial isostatic uplift, information otherwise lacking from the continental interior but of particular importance for modelling former ice sheet volumes and understanding the crustal response to ice sheet loading. Reconstructing the extents and timing of ice-dammed lakes and the study of related landforms and deposits can therefore greatly improve our understanding of the final decay of the Scandinavian Ice Sheet and provide potential analogues for the predictedfuture behaviours of modern ice sheets.
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| 6. |
- Stroeven, Arjen P., et al.
(författare)
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Deglaciation of Fennoscandia
- 2016
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 147:SI, s. 91-121
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Tidskriftsartikel (refereegranskat)abstract
- To provide a new reconstruction of the deglaciation of the Fennoscandian Ice Sheet, in the form of calendar-year time-slices, which are particularly useful for ice sheet modelling, we have compiled and synthesized published geomorphological data for eskers, ice-marginal formations, lineations, marginal meltwater channels, striae, ice-dammed lakes, and geochronological data from radiocarbon, varve, optically-stimulated luminescence, and cosmogenic nuclide dating. This is summarized as a deglaciation map of the Fennoscandian Ice Sheet with isochrons marking every 1000 years between 22 and 13 cal kyr BP and every hundred years between 11.6 and final ice decay after 9.7 cal kyr BP. Deglaciation patterns vary across the Fennoscandian Ice Sheet domain, reflecting differences in climatic and geomorphic settings as well as ice sheet basal thermal conditions and terrestrial versus marine margins. For example, the ice sheet margin in the high-precipitation coastal setting of the western sector responded sensitively to climatic variations leaving a detailed record of prominent moraines and other ice-marginal deposits in many fjords and coastal valleys. Retreat rates across the southern sector differed between slow retreat of the terrestrial margin in western and southern Sweden and rapid retreat of the calving ice margin in the Baltic Basin. Our reconstruction is consistent with much of the published research. However, the synthesis of a large amount of existing and new data support refined reconstructions in some areas. For example, the LGM extent of the ice sheet in northwestern Russia was located far east and it occurred at a later time than the rest of the ice sheet, at around 17-15 cal kyr BP. We also propose a slightly different chronology of moraine formation over southern Sweden based on improved correlations of moraine segments using new LiDAR data and tying the timing of moraine formation to Greenland ice core cold stages. Retreat rates vary by as much as an order of magnitude in different sectors of the ice sheet, with the lowest rates on the high-elevation and maritime Norwegian margin. Retreat rates compared to the climatic information provided by the Greenland ice core record show a general correspondence between retreat rate and climatic forcing, although a close match between retreat rate and climate is unlikely because of other controls, such as topography and marine versus terrestrial margins. Overall, the time slice reconstructions of Fennoscandian Ice Sheet deglaciation from 22 to 9.7 cal kyr BP provide an important dataset for understanding the contexts that underpin spatial and temporal patterns in retreat of the Fennoscandian Ice Sheet, and are an important resource for testing and refining ice sheet models.
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| 7. |
- Volz, Erik, et al.
(författare)
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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- 2021
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Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 184:1, s. 11-75
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Tidskriftsartikel (refereegranskat)abstract
- Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
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