| 1. |
|
|
| 2. |
|
|
| 3. |
- BORALV, E, et al.
(författare)
-
USABILITY AND EFFICIENCY - THE HELIOS APPROACH TO DEVELOPMENT OF USER INTERFACES
- 1994
-
Ingår i: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. - 0169-2607. ; 45, s. S47-S64
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper describes the user interface related services of the HELIOS project. The design and implementation of efficient user interfaces is a prerequisite for successful introduction of computer support in health care ward units. Design principles must be based on a basic understanding of cognitive aspects of human-computer interaction, as well as on detailed knowledge about the specific needs and requirements of the health care professionals. In the HELIOS project, a style guide for design of user interfaces has been developed. The style guide defines detailed design guide-lines together with a set of interface elements specified for the ward domain. Development tools for construction and implementation of user interfaces to ward applications have been developed and integrated into the HELIOS SEE. The tools are based on the TeleUSE product, which has been extended and adjusted to the HELIOS specifications. A set of new widgets, designed to implement health care interface elements, has been incorporated into the development tool.
|
|
| 4. |
- Händel, Peter, 1962-, et al.
(författare)
-
Analysis of a simple, effective frequency estimator based on Prony’s method
- 1998
-
Ingår i: Statistical Signal and Array Processing, 1998. Proceedings., Ninth IEEE SP Workshop on. ; , s. 316-319
-
Konferensbidrag (refereegranskat)abstract
- In a recent paper by Tufts and Fiore (1996) a low-complexity frequency estimator based on Prony’s method was proposed. The estimate is formed from two sample correlations r circ;(L1) and r circ;(L2), where 1 les;L1 les;L2 les;N-1 and N is the number of samples. For a correct phase unwrapping it is required that L1 and L2 are relatively prime. In this paper, a slight modification of the original algorithm is presented, and an expression for its asymptotic variance is derived. It is shown that the error variance is minimized for L1=3N/5 and L2=4N/5 for which the quotient of the error variance and the Cramer-Rao bound tends to 25/24 ap;1.042. Suboptimal settings of L1 and L2 are shown to exist, resulting in a lowered SNR-threshold while retaining the asymptotic efficiency. Simulation results which lend support to the theoretical findings are included
|
|
| 5. |
- Lauvsnes, M. B., et al.
(författare)
-
Neurofilament light in plasma is a potential biomarker of central nervous system involvement in systemic lupus erythematosus
- 2022
-
Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 269, s. 3064-3074
-
Tidskriftsartikel (refereegranskat)abstract
- Background Neuropsychiatric manifestations (NP) are common in systemic lupus erythematosus (SLE). However, the pathophysiological mechanisms are not completely understood. Neurofilament light protein (NfL) is part of the neuronal cytoskeleton. Increased NfL concentrations, reflecting neurodegeneration, is observed in cerebrospinal fluid (CSF) in several neurodegenerative and neuroinflammatory conditions. We aimed to explore if plasma NfL could serve as a biomarker for central nervous system (CNS) involvement in SLE. Methods Sixty-seven patients with SLE underwent neurological examination; 52 underwent lumbar puncture, while 62 underwent cerebral magnetic resonance imaging (MRI). We measured selected auto-antibodies and other laboratory variables postulated to have roles in NP pathophysiology in the blood and/or CSF. We used SPM12 software for MRI voxel-based morphometry. Results Age-adjusted linear regression analyses revealed increased plasma NfL concentrations with increasing creatinine (beta = 0.01, p < 0.001) and Q-albumin (beta = 0.07, p = 0.008). We observed higher plasma NfL concentrations in patients with a history of seizures (beta = 0.57, p = 0.014), impaired motor function (beta = 0.36, p = 0.008), increasing disease activity (beta = 0.04, p = 0.008), and organ damage (beta = 0.10, p = 0.002). Voxel-based morphometry suggested an association between increasing plasma NfL concentrations and the loss of cerebral white matter in the corpus callosum and hippocampal gray matter. Conclusion Increased plasma NfL concentrations were associated with some abnormal neurological, cognitive, and neuroimaging findings. However, plasma NfL was also influenced by other factors, such as damage accrual, creatinine, and Q-albumin, thereby obscuring the interpretation of how plasma NfL reflects CNS involvement. Taken together, NfL in CSF seems a better marker of neuronal injury than plasma NfL in patients with SLE.
|
|
| 6. |
- Li, He, et al.
(författare)
-
Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
- 2017
-
Ingår i: PLOS Genetics. - : PUBLIC LIBRARY SCIENCE. - 1553-7390 .- 1553-7404. ; 13:6
-
Tidskriftsartikel (refereegranskat)abstract
- Sjogren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon (IFN) pathway is a prominent feature of SS and is correlated with increased autoantibody titers and disease severity. To identify genetic determinants of IFN pathway dysregulation in SS, we performed cis-expression quantitative trait locus (eQTL) analyses focusing on differentially expressed type I IFN-inducible transcripts identified through a transcriptome profiling study. Multiple cis-eQTLs were associated with transcript levels of 2'-5'-oligoadenylate synthetase 1 (OAS1) peaking at rs10774671 (PeQTL = 6.05 x 10(-14)). Association of rs10774671 with SS susceptibility was identified and confirmed through meta-analysis of two independent cohorts (P-meta = 2.59 x 10(-9); odds ratio = 0.75; 95% confidence interval = 0.66-0.86). The risk allele of rs10774671 shifts splicing of OAS1 from production of the p46 isoform to multiple alternative transcripts, including p42, p48, and p44. We found that the isoforms were differentially expressed within each genotype in controls and patients with and without autoantibodies. Furthermore, our results showed that the three alternatively spliced isoforms lacked translational response to type I IFN stimulation. The p48 and p44 isoforms also had impaired protein expression governed by the 3' end of the transcripts. The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment. Our results establish OAS1 as a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease.
|
|
| 7. |
|
|
| 8. |
- Berg, H, et al.
(författare)
-
Electronic structure and stability of the LixMn2O4 (0 < x < 2) system
- 1999
-
Ingår i: JOURNAL OF MATERIALS CHEMISTRY. - : ROYAL SOC CHEMISTRY. - 0959-9428. ; 9:11, s. 2813-2820
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- LMTO-ASA self-consistent band structure calculations have been performed for the cubic spinel LiMn2O4 and its delithiated and lithiated phases: lambda-MnO2 and Li2Mn2O4. It has been shown that the Jahn-Teller distortion plays a vital role le in the stabil
|
|
| 9. |
|
|
| 10. |
|
|
