2. |
- Peng, Xinxia, et al.
(författare)
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The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease
- 2014
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 32:12, s. 1250-U114
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Tidskriftsartikel (refereegranskat)abstract
- The domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission(1-)4. Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We characterized the ferret host response to two influenza virus infections by RNA-seq analysis of 42 ferret samples from influenza time-course data and showed distinct signatures in ferret trachea and lung tissues specific to 1918 or 2009 human pandemic influenza virus infections. Using microarray data from 16 ferret samples reflecting cystic fibrosis disease progression, we showed that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.
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3. |
- Viola, Nicole, et al.
(författare)
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Stratofly mr3 – how to reduce the environmental impact of high-speed transportation
- 2021
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Ingår i: AIAA Scitech 2021 Forum. - 9781624106095 ; , s. 1-21
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Konferensbidrag (refereegranskat)abstract
- This paper addresses the main progresses and achievements of the H2020 STRATOFLY Project, funded by the European Commission, under the Horizon 2020 framework, specifically looking at the latest results in terms of environmental sustainability. In particular, starting from reporting the main environmental challenges posed by high-speed civil transportation, at local, regional and global levels, this paper describes the way in which the STRATOFLY MR3 vehicle, a Mach 8 waverider fueled with liquid hydrogen, promises to limit the overall environmental impact. In details, firstly, the paper describes some of the main technological improvements adopted to reduce the aircraft emission and then it reports about the status of the numerical and experimental test campaigns on the high-speed engine, showing the results achieved so far. This preliminary emission inventory allows for the evaluation of emission indexes throughout the mission profile, the verification of the compliance with the ICAO prescriptions, the estimation of the impact on air quality and climate and eventually, when necessary, the paper proposes adequate mitigation actions.
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