| 1. |
- Baum, Sebastian, et al.
(författare)
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Paleodetectors for Galactic supernova neutrinos
- 2020
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Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 101:10
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Tidskriftsartikel (refereegranskat)abstract
- Paleodetectors are a proposed experimental technique in which one would search for traces of recoiling nuclei in ancient minerals. Natural minerals on Earth are as old as O(1) Gyr and, in many minerals, the damage tracks left by recoiling nuclei are also preserved for timescales long compared to 1 Gyr once created. Thus, even reading out relatively small target samples of order 100 g, paleodetectors would allow one to search for very rare events thanks to the large exposure, epsilon similar to 100 g Gyr = 10(5) t yr. Here, we explore the potential of paleodetectors to measure nuclear recoils induced by neutrinos from Galactic core collapse supernovae. We find that they would not only allow for a direct measurement of the average core collapse supernova rate in the Milky Way, but would also contain information about the time dependence of the local supernova rate over the past similar to 1 Gyr. Since the supernova rate is thought to be directly proportional to the star formation rate, such a measurement would provide a determination of the local star formation history. We investigate the sensitivity of paleodetectors to both a smooth time evolution and an enhancement of the core collapse supernova rate on relatively short timescales, as would be expected for a starburst period in the local group.
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| 2. |
- Baum, Sebastian, et al.
(författare)
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Searching for dark matter with paleo-detectors
- 2020
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Ingår i: Physics Letters B. - : ELSEVIER. - 0370-2693 .- 1873-2445. ; 803
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Tidskriftsartikel (refereegranskat)abstract
- A large experimental program is underway to extend the sensitivity of direct detection experiments, searching for interaction of Dark Matter with nuclei, down to the neutrino floor. However, such experiments are becoming increasingly difficult and costly due to the large target masses and exquisite background rejection needed for the necessary improvements in sensitivity. We investigate an alternative approach to the detection of Dark Matter-nucleon interactions: Searching for the persistent traces left by Dark Matter scattering in ancient minerals obtained from much deeper than current underground laboratories. We estimate the sensitivity of paleo-detectors, which extends far beyond current upper limits for a wide range of Dark Matter masses. The sensitivity of our proposal also far exceeds the upper limits set by Snowden-Ifft et al. more than three decades ago using ancient Mica in an approach similar to paleo-detectors.
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| 3. |
- Baum, Sebastian, et al.
(författare)
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Searching for Dark Matter with Paleo-Detectors
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- A large experimental program is underway to extend the sensitivity of direct detection experiments, searching for interactions of Dark Matter with nuclei, down to the neutrino floor. However, such experiments are becoming increasingly difficult and costly due to the large target masses and exquisite background rejection needed for the necessary improvements in sensitivity. We investigate an alternative approach to the detection of Dark Matter--nucleon interactions: Searching for the persistent traces left by Dark Matter scattering in ancient minerals obtained from much deeper than current underground laboratories. We estimate the sensitivity of paleo-detectors, which extends far beyond current upper limits for a wide range of Dark Matter masses.
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| 4. |
- Chylenski, Maciej, et al.
(författare)
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Patrilocality and hunter-gatherer-related ancestry of populations in East-Central Europe during the Middle Bronze Age
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- The demographic history of East-Central Europe after the Neolithic period remains poorly explored, despite this region being on the confluence of various ecological zones and cultural entities. Here, the descendants of societies associated with steppe pastoralists form Early Bronze Age were followed by Middle Bronze Age populations displaying unique characteristics. Particularly, the predominance of collective burials, the scale of which, was previously seen only in the Neolithic. The extent to which this re-emergence of older traditions is a result of genetic shift or social changes in the MBA is a subject of debate. Here by analysing 91 newly generated genomes from Bronze Age individuals from present Poland and Ukraine, we discovered that Middle Bronze Age populations were formed by an additional admixture event involving a population with relatively high proportions of genetic component associated with European hunter-gatherers and that their social structure was based on, primarily patrilocal, multigenerational kin-groups. By analysing 91 Bronze Age genomes from East-Central Europe, the authors discovered that Middle Bronze Age populations were formed by an admixture event involving hunter-gatherers and that the social structure of resulting population was primarily patrilocal.
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| 5. |
- Drukier, Andrzej K., et al.
(författare)
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Paleo-detectors : Searching for Dark Matter with Ancient Minerals
- 2019
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Ingår i: Physical Review D. Particles and fields. - : AMER PHYSICAL SOC. - 0556-2821 .- 1089-4918. ; 99:4
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Tidskriftsartikel (refereegranskat)abstract
- We explore paleo-detectors as an approach to the direct detection of weakly interacting massive particle (WIMP) dark matter radically different from conventional detectors. Instead of instrumenting a (large) target mass in a laboratory in order to observe WIMP-induced nuclear recoils in real time, the approach is to examine ancient minerals for traces of WIMP-nucleus interactions recorded over timescales as large as 1 Gyr. Here, we discuss the paleo-detector proposal in detail, including background sources and possible target materials. In order to suppress backgrounds induced by radioactive contaminants such as uranium, we propose to use minerals found in marine evaporites or in ultrabasic rocks. We estimate the sensitivity of paleo-detectors to spin-independent and spin-dependent WIMP-nucleus interactions. The sensitivity to low-mass WIMPs with masses mχ≲10 GeV extends to WIMP-nucleon cross sections many orders of magnitude smaller than current upper limits. For heavier WIMPs with masses mχ≳30 GeV cross sections a factor of a few to ∼100 smaller than current upper limits can be probed by paleo-detectors.
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| 6. |
- Edwards, Thomas D. P., et al.
(författare)
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Digging for dark matter : Spectral analysis and discovery potential of paleo-detectors
- 2019
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Ingår i: Physical Review D. Particles and fields. - : AMER PHYSICAL SOC. - 0556-2821 .- 1089-4918. ; 99:4
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Tidskriftsartikel (refereegranskat)abstract
- Paleo-detectors are a recently proposed method for the direct detection of dark matter (DM). In such detectors, one would search for the persistent damage features left by DM–nucleus interactions in ancient minerals. Initial sensitivity projections have shown that paleo-detectors could probe much of the remaining weakly interacting massive particle (WIMP) parameter space. In this paper, we improve upon the cut-and-count approach previously used to estimate the sensitivity by performing a full spectral analysis of the background- and DM-induced signal spectra. We consider two scenarios for the systematic errors on the background spectra: (i) systematic errors on the normalization only, and (ii) systematic errors on the shape of the backgrounds. We find that the projected sensitivity is rather robust to imperfect knowledge of the backgrounds. Finally, we study how well the parameters of the true WIMP model could be reconstructed in the hypothetical case of a WIMP discovery.
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| 7. |
- Juras, Anna, et al.
(författare)
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Mitochondrial genomes from Bronze Age Poland reveal genetic continuity from the Late Neolithic and additional genetic affinities with the steppe populations
- 2020
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Ingår i: American Journal of Physical Anthropology. - : Wiley. - 0002-9483 .- 1096-8644. ; 172:2, s. 176-188
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Tidskriftsartikel (refereegranskat)abstract
- Objective: In this work we aim to investigate the origins and genetic affinities of Bronze Age populations (2,400-1,100 BC) from the region of southern Poland and to trace maternal kinship patterns present in the burials of those populations by the use of complete mitochondrial genomes.Materials and methods: We performed ancient DNA analyses for Bronze Age individuals from present-day Poland associated with the Strzy(z) over dotow culture, the Mierzanowice culture, and the Trzciniec Cultural circle. To obtain complete mitochondrial genomes, we sequenced genomic libraries using Illumina platform. Additionally, hybridization capture was used to enrich some of the samples for mitochondrial DNA. AMS C-14-dating was conducted for 51 individuals to verify chronological and cultural attribution of the analyzed samples.Results: Complete ancient mitochondrial genomes were generated for 80 of the Bronze Age individuals from present-day Poland. The results of the population genetic analyses indicate close maternal genetic affinity between Mierzanowice, Trzciniec, and Corded Ware culture-associated populations. This is in contrast to the genetically more distant Strzy(z) over dotow people that displayed closer maternal genetic relation to steppe populations associated with the preceding Yamnaya culture and Catacomb culture, and with later Scythians. Potential maternal kinship relations were identified in burials of Mierzanowice and Trzciniec populations analyzed in this study.Discussion: Results revealed genetic continuity from the Late Neolithic Corded Ware groups to Bronze Age Mierzanowice and Trzciniec-associated populations, and possible additional genetic contribution from the steppe to the formation of the Strzy(z) over dotow-associated group at the end of 3rd millennium BC. Mitochondrial patterns indicated several pairs of potentially maternally related individuals mostly in Trzciniec-associated group.
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| 8. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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