| 1. |
- Bousquet, J., et al.
(författare)
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Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA
- 2017
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Nature. - 1279-7707 .- 1760-4788. ; 21:1, s. 92-104
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Tidskriftsartikel (refereegranskat)abstract
- The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
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| 2. |
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| 3. |
- Mercati, O, et al.
(författare)
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CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.
- 2017
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Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 22, s. 625-633
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Tidskriftsartikel (refereegranskat)abstract
- Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact. In this study, we identified CNTN5 and CNTN6 deleterious variants in individuals with ASD. Among the carriers, a girl with ASD and attention-deficit/hyperactivity disorder was carrying five copies of CNTN5. For CNTN6, both deletions (6/1534 ASD vs 1/8936 controls; P=0.00006) and private coding sequence variants (18/501 ASD vs 535/33480 controls; P=0.0005) were enriched in individuals with ASD. Among the rare CNTN6 variants, two deletions were transmitted by fathers diagnosed with ASD, one stop mutation CNTN6(W923X) was transmitted by a mother to her two sons with ASD and one variant CNTN6(P770L) was found de novo in a boy with ASD. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway. These results reinforce the hypothesis of abnormal neuronal connectivity in the pathophysiology of ASD and shed new light on the genes that increase risk for abnormal sensory perception in ASD.Molecular Psychiatry advance online publication, 10 May 2016; doi:10.1038/mp.2016.61.
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| 4. |
- Carbol, P., et al.
(författare)
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Hydrogen suppresses UO2 corrosion
- 2009
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Ingår i: Geochimica et Cosmochimica Acta. - : Elsevier BV. - 0016-7037 .- 0046-564X. ; 73:15, s. 4366-4375
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Tidskriftsartikel (refereegranskat)abstract
- Release of long-lived radionuclides such as plutonium and caesium from spent nuclear fuel in deep geological repositories will depend mainly on the dissolution rate of the UO2 fuel matrix. This dissolution rate will, in turn, depend on the redox conditions at the fuel surface. Under oxidative conditions UO2 will be oxidised to the 1000 times more soluble UO2.67. This may occur in a repository as the reducing deep groundwater becomes locally oxidative at the fuel surface under the effect of alpha-radiolysis, the process by which alpha-particles emitted from the fuel split water molecules. On the other hand, the groundwater corrodes canister iron generating large amounts of hydrogen. The role of molecular hydrogen as reductant in a deep bedrock repository is questioned. Here we show evidence of a surface-catalysed reaction, taking place in the H-2-UO2-H2O system where molecular hydrogen is able to reduce oxidants originating from alpha-radiolysis. In our experiment the UO2 surface remained stoichiometric proving that the expected oxidation of UO2.00 to UO2.67 due to radiolytic oxidants was absent. As a consequence, the dissolution of UO2 stopped when equilibrium was reached between the solid phase and U4+ species in the aqueous phase. The steady-state concentration of uranium in solution was determined to be 9 x 10(-12) M, about 30 times lower than previously reported for reducing conditions. Our findings show that fuel dissolution is suppressed by H-2. Consequently, radiotoxic nuclides in spent nuclear fuel will remain immobilised in the UO2 matrix. A mechanism for the surface-catalysed reaction between molecular hydrogen and radiolytic oxidants is proposed. (C) 2009 Elsevier Ltd. All rights reserved.
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| 5. |
- Eckle, M, et al.
(författare)
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Electronic structure of UCx films prepared by sputter co-deposition
- 2004
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 334:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Thin layers of UCx (x = 0-12) have been prepared by sputter co-deposition of uranium and carbon in an Ar atmosphere. The films were investigated in-situ by ultraviolet and X-ray photoelectron spectroscopy (UPS and XPS, respectively). Special interest was put on the evolution of the electronic structure with the composition of the films, as deduced from the U-4f, C-1s and valence region spectra. With increasing carbon content, three types of carbon species were detected according to C-1s core level line, at 282, 282.6 and 284.5 eV binding energy (BE). They are attributed to the UC, UC2 and graphite phases, respectively. The U-4f core levels do not change strongly with increasing carbon content, showing well-itinerant U-5f electrons. Similarly, valence region spectra show three types of carbon species for different UCx films, which are differentiated by their C-2p signals. A strong hybridisation between C-2p and U-5f states is detected in UC, while the C-2p signal in UC2 appears only weakly hybridised, and for higher carbon contents a pi band characteristic of graphite appears.
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| 6. |
- El Jamal, Ghada, et al.
(författare)
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Mixed H2O/H2plasma-induced redox reactions of thin uranium oxide films under UHV conditions
- 2021
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Ingår i: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; 50:36, s. 12583-12591
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Tidskriftsartikel (refereegranskat)abstract
- X-ray photoelectron spectroscopy (XPS) has been used to study the effect of mixed H2O/H2gas plasma on the surfaces of UO2, U2O5and UO3thin films at 400 °C. The experiments were performedin situunder ultra-high vacuum conditions. Deconvolution of the U4f7/2peaks into U(iv), U(v) and U(vi) components revealed the surface composition of the films after 10 min plasma exposure as a function of H2concentration in the feed gas of the plasma. Some selected films (unexposed and exposed) were also analysed using grazing-incidence X-ray diffraction (GIXRD). The XPS results show that U(v) is formed as a major product upon 10 minutes exposure of UO3by a mixed H2O/H2plasma in a fairly wide H2concentration range. When starting with U(v) (U2O5), rather high H2concentrations are needed to reduce U(v) to U(iv) in 10 minutes. In the plasma induced oxidation of UO2, U(v) is never observed as a major product after 10 minutes and it would seem that once U(v) is formed in the oxidation of UO2it is rapidly oxidized further to U(vi). The grazing incidence X-ray diffraction analysis shows that there is a considerable impact of the plasma and heating conditions on the crystal structure of the films in line with the change of the oxidation state. This structural difference is proposed to be the main kinetic barrier for plasma induced transfer between U(iv) and U(v) in both directions.
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| 7. |
- Eloirdi, R., et al.
(författare)
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Dilution effect on the U-5f states : U in an Ag matrix
- 2005
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 386:1-2, s. 70-74
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Tidskriftsartikel (refereegranskat)abstract
- The electronic structure of U-diluted in an Ag matrix has been studied in situ by ultraviolet and X-ray photoelectron spectroscopy (UPS and XPS, respectively). UxAg100-x thin films (x = 0-100 at.%) were produced by sputter co-deposition in an Ar atmosphere. UPS spectra of the Ag-4d line indicate formation of a homogeneous mixture despite the fact that U and Ag do not form stable alloys. A major goal of this work was to find out whether the dilution of U atoms in an inert matrix with no bonding states induces the localisation of the U-5f states. Both U-4f core level spectra and the U-5f spectra indicate U-5f delocalisation, down to 5 at.% of uranium in UxAg100-x films.
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| 8. |
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