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- van Waalwijk van Doorn, Linda J C, et al.
(författare)
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Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
- 2017
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 56:2, s. 543-555
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Tidskriftsartikel (refereegranskat)abstract
- Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r=-0.28; p<0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r=-0.15; p-tau: r=-0.13; both p<0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF Aβ42 alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF Aβ42 levels.
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| 2. |
- Zhang, Yichen, et al.
(författare)
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Massive Protostars in a Protocluster—A Multi-scale ALMA View of G35.20-0.74N
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 936:1
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Tidskriftsartikel (refereegranskat)abstract
- We present a detailed study of the massive star-forming region G35.2-0.74N with Atacama Large Millimeter/submillimeter Array (ALMA) 1.3 mm multi-configuration observations. At 0.″2 (440 au) resolution, the continuum emission reveals several dense cores along a filamentary structure, consistent with previous ALMA 0.85 mm observations. At 0.″03 (66 au) resolution, we detect 22 compact sources, most of which are associated with the filament. Four of the sources are associated with compact centimeter continuum emission, and two of these are associated with H30α recombination line emission. The H30α line kinematics shows the ordered motion of the ionized gas, consistent with disk rotation and/or outflow expansion. We construct models of photoionized regions to simultaneously fit the multiwavelength free-free fluxes and the H30α total fluxes. The derived properties suggest the presence of at least three massive young stars with nascent hypercompact H ii regions. Two of these ionized regions are surrounded by a large rotating structure that feeds two individual disks, revealed by dense gas tracers, such as SO2, H2CO, and CH3OH. In particular, the SO2 emission highlights two spiral structures in one of the disks and probes the faster-rotating inner disks. The 12CO emission from the general region reveals a complex outflow structure, with at least four outflows identified. The remaining 18 compact sources are expected to be associated with lower-mass protostars forming in the vicinity of the massive stars. We find potential evidence for disk disruption due to dynamic interactions in the inner region of this protocluster. The spatial distribution of the sources suggests a smooth overall radial density gradient without subclustering, but with tentative evidence of primordial mass segregation.
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