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Sökning: WFRF:(Grinberg Keren)

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1.
  • Jack, Kirsten, et al. (författare)
  • Clinical leadership in nursing students: A concept analysis.
  • 2022
  • Ingår i: Nurse education today. - : Elsevier BV. - 1532-2793 .- 0260-6917. ; 108
  • Tidskriftsartikel (refereegranskat)abstract
    • To undertake a concept analysis of clinical leadership in nursing students.Concept analysis.A comprehensive search was conducted using the Cumulative Index of Nursing and Allied Health Literature (CINAHL), Medline and PsychINFO using the following search terms: clinical leadership AND management AND preregistration OR pre-registration OR undergraduate AND nursing student* OR student nurse*.Nursing student clinical leadership was explored using the eight-step process of concept analysis proposed by Walker and Avant (2014).The defining attributes included effective interpersonal communication skills, contemporary clinical knowledge and being a role model to others.This concept analysis provides a definition of clinical leadership in nursing students. It will support understanding of the concept and how it is enacted in clinical placement settings.
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2.
  • Maicher, André, et al. (författare)
  • Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres
  • 2017
  • Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 13:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Ribonucleotide reductase (RNR) provides the precursors for the generation of dNTPs, which are required for DNA synthesis and repair. Here, we investigated the function of the major RNR subunits Rnr1 and Rnr3 in telomere elongation in budding yeast. We show that Rnr1 is essential for the sustained elongation of short telomeres by telomerase. In the absence of Rnr1, cells harbor very short, but functional, telomeres, which cannot become elongated by increased telomerase activity or by tethering of telomerase to telomeres. Furthermore, we demonstrate that Rnr1 function is critical to prevent an early onset of replicative senescence and premature survivor formation in telomerase-negative cells but dispensable for telomere elongation by Homology-Directed-Repair. Our results suggest that telomerase has a "basal activity" mode that is sufficient to compensate for the "end-replication-problem" and does not require the presence of Rnr1 and a different "sustained activity" mode necessary for the elongation of short telomeres, which requires an upregulation of dNTP levels and dGTP ratios specifically through Rnr1 function. By analyzing telomere length and dNTP levels in different mutants showing changes in RNR complex composition and activity we provide evidence that the Mec1ATR checkpoint protein promotes telomere elongation by increasing both dNTP levels and dGTP ratios through Rnr1 upregulation in a mechanism that cannot be replaced by its homolog Rnr3.
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