SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Guerra Susana) "

Sökning: WFRF:(Guerra Susana)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Bernal, Ximena E., et al. (författare)
  • Empowering Latina scientists
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
2.
  • Calvo, Patricia A, et al. (författare)
  • Motif WFYY of human PrimPol is crucial to stabilize the incoming 3'-nucleotide during replication fork restart
  • 2021
  • Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 49:14, s. 8199-8213
  • Tidskriftsartikel (refereegranskat)abstract
    • PrimPol is the second primase in human cells, the first with the ability to start DNA chains with dNTPs. PrimPol contributes to DNA damage tolerance by restarting DNA synthesis beyond stalling lesions, acting as a TLS primase. Multiple alignment of eukaryotic PrimPols allowed us to identify a highly conserved motif, WxxY near the invariant motif A, which contains two active site metal ligands in all members of the archeo-eukaryotic primase (AEP) superfamily. In vivo and in vitro analysis of single variants of the WFYY motif of human PrimPol demonstrated that the invariant Trp87 and Tyr90 residues are essential for both primase and polymerase activities, mainly due to their crucial role in binding incoming nucleotides. Accordingly, the human variant F88L, altering the WFYY motif, displayed reduced binding of incoming nucleotides, affecting its primase/polymerase activities especially during TLS reactions on UV-damaged DNA. Conversely, the Y89D mutation initially associated with High Myopia did not affect the ability to rescue stalled replication forks in human cells. Collectively, our data suggest that the WFYY motif has a fundamental role in stabilizing the incoming 3'-nucleotide, an essential requisite for both its primase and TLS abilities during replication fork restart.
  •  
3.
  •  
4.
  • Potapov, Anton M., et al. (författare)
  • Globally invariant metabolism but density-diversity mismatch in springtails
  • 2023
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Soil life supports the functioning and biodiversity of terrestrial ecosystems. Springtails (Collembola) are among the most abundant soil arthropods regulating soil fertility and flow of energy through above- and belowground food webs. However, the global distribution of springtail diversity and density, and how these relate to energy fluxes remains unknown. Here, using a global dataset representing 2470 sites, we estimate the total soil springtail biomass at 27.5 megatons carbon, which is threefold higher than wild terrestrial vertebrates, and record peak densities up to 2 million individuals per square meter in the tundra. Despite a 20-fold biomass difference between the tundra and the tropics, springtail energy use (community metabolism) remains similar across the latitudinal gradient, owing to the changes in temperature with latitude. Neither springtail density nor community metabolism is predicted by local species richness, which is high in the tropics, but comparably high in some temperate forests and even tundra. Changes in springtail activity may emerge from latitudinal gradients in temperature, predation and resource limitation in soil communities. Contrasting relationships of biomass, diversity and activity of springtail communities with temperature suggest that climate warming will alter fundamental soil biodiversity metrics in different directions, potentially restructuring terrestrial food webs and affecting soil functioning.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (4)
Typ av innehåll
refereegranskat (3)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Zhang, Yan (1)
Korhonen, Laura (1)
Lindholm, Dan (1)
Vertessy, Beata G. (1)
Wang, Mei (1)
Wang, Xin (1)
visa fler...
Liu, Yang (1)
Kumar, Rakesh (1)
Wang, Dong (1)
Li, Ke (1)
Liu, Ke (1)
Zhang, Yang (1)
Nàgy, Péter (1)
Kominami, Eiki (1)
van der Goot, F. Gis ... (1)
Bonaldo, Paolo (1)
Thum, Thomas (1)
Adams, Christopher M (1)
Minucci, Saverio (1)
Vellenga, Edo (1)
Swärd, Karl (1)
Nilsson, Per (1)
De Milito, Angelo (1)
Zhang, Jian (1)
Shukla, Deepak (1)
Kågedal, Katarina (1)
Chen, Guoqiang (1)
Liu, Wei (1)
Cheetham, Michael E. (1)
Sigurdson, Christina ... (1)
Clarke, Robert (1)
Zhang, Fan (1)
Gonzalez-Alegre, Ped ... (1)
Jin, Lei (1)
Chen, Qi (1)
Taylor, Mark J. (1)
Ahlbäck Widenfalk, L ... (1)
Romani, Luigina (1)
Wang, Ying (1)
Kumar, Ashok (1)
Simons, Matias (1)
Ishaq, Mohammad (1)
Yang, Qian (1)
Algül, Hana (1)
Brest, Patrick (1)
Simon, Hans-Uwe (1)
Mograbi, Baharia (1)
Florey, Oliver (1)
Ström, Anna-Lena (1)
Chen, Wei (1)
visa färre...
Lärosäte
Umeå universitet (3)
Sveriges Lantbruksuniversitet (2)
Stockholms universitet (1)
Linköpings universitet (1)
Lunds universitet (1)
Chalmers tekniska högskola (1)
visa fler...
Karolinska Institutet (1)
visa färre...
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (4)
Medicin och hälsovetenskap (2)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy