| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Kristjansdottir, Gudlaug, et al.
(författare)
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Interferon Regulatory Factor 5 (IRF5) Gene Variants are Associated with Multiple Sclerosis in Three Distinct Populations
- 2008
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Ingår i: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 45:6, s. 362-369
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases. Here we investigated whether polymorphisms in the IRF5 gene would be associated with yet another disease with features of autoimmunity, multiple sclerosis (MS). METHODS: We genotyped nine single nucleotide polymorphisms and one insertion-deletion polymorphism in the IRF5 gene in a collection of 2337 patients with MS and 2813 controls from three populations: two case-control cohorts from Spain and Sweden, and a set of MS trio families from Finland. RESULTS: Two single nucleotide polymorphism (SNPs) (rs4728142, rs3807306), and a 5 bp insertion-deletion polymorphism located in the promoter and first intron of the IRF5 gene, showed association signals with values of p<0.001 when the data from all cohorts were combined. The predisposing alleles were present on the same common haplotype in all populations. Using electrophoretic mobility shift assays we observed allele specific differences in protein binding for the SNP rs4728142 and the 5 bp indel, and by a proximity ligation assay we demonstrated increased binding of the transcription factor SP1 to the risk allele of the 5 bp indel. CONCLUSION: These findings add IRF5 to the short list of genes shown to be associated with MS in more than one population. Our study adds to the evidence that there might be genes or pathways that are common in multiple autoimmune diseases, and that the type I interferon system is likely to be involved in the development of these diseases.
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| 4. |
- Albert, Marie Christine, et al.
(författare)
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Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality
- 2024
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Ingår i: Cell Death and Differentiation. - 1350-9047.
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Tidskriftsartikel (refereegranskat)abstract
- The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
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| 5. |
- Carpio, Antonio J., et al.
(författare)
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Hunting as a source of alien species : a European review
- 2017
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Ingår i: Biological Invasions. - : Springer Science and Business Media LLC. - 1387-3547 .- 1573-1464. ; 19:4, s. 1197-1211
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Tidskriftsartikel (refereegranskat)abstract
- Hunting activities are responsible for the translocation and restocking of millions of animals throughout Europe, including the introduction of alien species. In a context of the growing use of game translocations and of increasing concern about the impact of biological invasions, our goal is to review the role of alien species introduced primarily for hunting purposes on the European scale. In particular, we explore: (1) the relative importance of game species in the context of alien species introductions; (2) the temporal evolution of the number of species introduced for hunting purposes; (3) the contribution of different taxa; (4) the pattern of introduced game species composition across countries (in terms of similarity), and (5) the underlying human demographic factors driving the diversity of introduced game species per country. According to our results, 24.3% of the mammals and 30.2% of the birds introduced into Europe during the last century were released primarily for hunting purposes, in total, 93 species (63 birds and 36 mammals), the most important taxa being Artiodactyls, Anseriformes and Galliformes. The species composition differed among countries, with a higher diversity of introduced game species in larger countries and in those with a higher human population density and proportion of hunters. This review stresses that hunting was a significant pathway for the introduction of invasive species into Europe in the last century. Since some of the game species introduced have had severe environmental impacts on many European regions, and introductions of non-native game species are still occurring, it is essential to improve regulations and increase public awareness regarding invasive game animals. This will help to preserve biodiversity and improve the sustainability of current hunting schemes in increasingly managed European ecosystems.
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| 9. |
- Hurtig, Anna Karin, et al.
(författare)
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Pesticide use among farmers in the Amazon basin of Ecuador.
- 2003
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Ingår i: Archives of Environmental Health. - 0003-9896. ; 58:4, s. 223-8
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Tidskriftsartikel (refereegranskat)abstract
- Pesticide use is one of the most significant occupational exposures for agricultural workers in the Amazon basin of Ecuador. A structured questionnaire was developed focusing on sociodemographic characteristics, knowledge and experience of adverse health effects related to pesticide use, details of work practices, and an inventory of pesticides used on the farm. Of the 112 farmers interviewed, 111 (99.1%) used pesticides. Paraquat was most commonly used (77.4%), followed by glyphosate (65.7%). Respondents had good knowledge about the acute health effects of pesticides and their exposure routes. Risk behaviors were identified as frequent pesticide use, washing pesticide equipment in water sources used by humans, inadequate disposal of empty pesticide containers, eating and drinking during pesticide application, and using inadequate protective clothing. Training and educational campaigns on pesticide use should be encouraged for this cohort, along with suggestions for alternative methods of pest control.
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