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- 2019
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Guo, Jing, et al.
(författare)
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Prediction of variability of precipitation in the Yangtze River Basin under the climate change conditions based on automated statistical downscaling
- 2012
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Ingår i: Stochastic environmental research and risk assessment (Print). - : Springer Science and Business Media LLC. - 1436-3240 .- 1436-3259. ; 26:2, s. 157-176
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Tidskriftsartikel (refereegranskat)abstract
- Many impact studies require climate change information at a finer resolution than that provided by general circulation models (GCMs). Therefore the outputs from GCMs have to be downscaled to obtain the finer resolution climate change scenarios. In this study, an automated statistical downscaling (ASD) regression-based approach is proposed for predicting the daily precipitation of 138 main meteorological stations in the Yangtze River basin for 2010-2099 by statistical downscaling of the outputs of general circulation model (HadCM3) under A2 and B2 scenarios. After that, the spatial-temporal changes of the amount and the extremes of predicted precipitation in the Yangtze River basin are investigated by Mann-Kendall trend test and spatial interpolation. The results showed that: (1) the amount and the change pattern of precipitation could be reasonably simulated by ASD; (2) the predicted annual precipitation will decrease in all sub-catchments during 2020s, while increase in all sub-catchments of the Yangtze River Basin during 2050s and during 2080s, respectively, under A2 scenario. However, they have mix-trend in each sub-catchment of Yangtze River basin during 2020s, but increase in all sub-catchments during 2050s and 2080s, except for Hanjiang River region during 2080s, as far as B2 scenario is concerned; and (3) the significant increasing trend of the precipitation intensity and maximum precipitation are mainly occurred in the northwest upper part and the middle part of the Yangtze River basin for the whole year and summer under both climate change scenarios and the middle of 2040-2060 can be regarded as the starting point for pattern change of precipitation maxima.
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| 5. |
- Ariyawansa, Hiran A., et al.
(författare)
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Fungal diversity notes 111–252—taxonomic and phylogenetic contributions to fungal taxa
- 2015
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Ingår i: Fungal diversity. - : Springer Science and Business Media LLC. - 1560-2745 .- 1878-9129. ; 75, s. 27-274
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Tidskriftsartikel (refereegranskat)abstract
- This paper is a compilation of notes on 142 fungal taxa, including five new families, 20 new genera, and 100 new species, representing a wide taxonomic and geographic range. The new families, Ascocylindricaceae, Caryosporaceae and Wicklowiaceae (Ascomycota) are introduced based on their distinct lineages and unique morphology. The new Dothideomycete genera Pseudomassariosphaeria (Amniculicolaceae), Heracleicola, Neodidymella and P s e u d o m i c ros p h a e r i o p s i s ( D id y m e l l a c e a e ) , P s e u d o p i t h o m y c e s ( D i d y m o s p h a e r i a c e a e ) , Brunneoclavispora, Neolophiostoma and Sulcosporium (Halotthiaceae), Lophiohelichrysum (Lophiostomataceae), G a l l i i c o l a , Popul o c re s c e n t i a a nd Va g i c o l a (Phaeosphaeriaceae), Ascocylindrica (Ascocylindricaceae), E l o n g a t o p e d i c e l l a t a ( R o u s s o e l l a c e a e ) , Pseudoasteromassaria (Latoruaceae) and Pseudomonodictys (Macrodiplodiopsidaceae) are introduced. The newly described species of Dothideomycetes (Ascomycota) are Pseudomassariosphaeria bromicola (Amniculicolaceae), Flammeascoma lignicola (Anteagloniaceae), Ascocylindrica marina (Ascocylindricaceae) , Lembosia xyliae (Asterinaceae), Diplodia crataegicola and Diplodia galiicola ( B o t r yosphae r i a cea e ) , Caryospor a aquat i c a (Caryosporaceae), Heracleicola premilcurensis and Neodi dymell a thai landi cum (Didymellaceae) , Pseudopithomyces palmicola (Didymosphaeriaceae), Floricola viticola (Floricolaceae), Brunneoclavispora bambusae, Neolophiostoma pigmentatum and Sulcosporium thailandica (Halotthiaceae), Pseudoasteromassaria fagi (Latoruaceae), Keissleriella dactylidicola (Lentitheciaceae), Lophiohelichrysum helichrysi (Lophiostomataceae), Aquasubmersa japonica (Lophiotremataceae) , Pseudomonodictys tectonae (Macrodiplodiopsidaceae), Microthyrium buxicola and Tumidispora shoreae (Microthyriaceae), Alloleptosphaeria clematidis, Allophaeosphaer i a c y t i s i , Allophaeosphae r i a subcylindrospora, Dematiopleospora luzulae, Entodesmium artemisiae, Galiicola pseudophaeosphaeria, Loratospora(Basidiomycota) are introduced together with a new genus Neoantrodiella (Neoantrodiellaceae), here based on both morphology coupled with molecular data. In the class Agaricomycetes, Agaricus pseudolangei, Agaricus haematinus, Agaricus atrodiscus and Agaricus exilissimus (Agaricaceae) , Amanita m e l l e i a l b a , Amanita pseudosychnopyramis and Amanita subparvipantherina (Amanitaceae), Entoloma calabrum, Cora barbulata, Dictyonema gomezianum and Inocybe granulosa (Inocybaceae), Xerocomellus sarnarii (Boletaceae), Cantharellus eucalyptorum, Cantharellus nigrescens, Cantharellus tricolor and Cantharellus variabilicolor (Cantharellaceae), Cortinarius alboamarescens, Cortinarius brunneoalbus, Cortinarius ochroamarus, Cortinarius putorius and Cortinarius seidlii (Cortinariaceae), Hymenochaete micropora and Hymenochaete subporioides (Hymenochaetaceae), Xylodon ramicida (Schizoporaceae), Colospora andalasii (Polyporaceae), Russula guangxiensis and Russula hakkae (Russulaceae), Tremella dirinariae, Tremella graphidis and Tremella pyrenulae (Tremellaceae) are introduced. Four new combinations Neoantrodiella gypsea, Neoantrodiella thujae (Neoantrodiellaceae), Punctulariopsis cremeoalbida, Punctulariopsis efibulata (Punctulariaceae) are also introduced here for the division Basidiomycota. Furthermore Absidia caatinguensis, Absidia koreana and Gongronella koreana (Cunninghamellaceae), Mortierella pisiformis and Mortierella formosana (Mortierellaceae) are newly introduced in the Zygomycota, while Neocallimastix cameroonii and Piromyces irregularis (Neocallimastigaceae) ar e i n t roduced i n the Neocallimastigomycota. Reference specimens or changes in classification and notes are provided for Alternaria ethzedia, Cucurbitaria ephedricola, Austropleospora, Austropleospora archidendri, Byssosphaeria rhodomphala, Lophiostoma caulium, Pseudopithomyces maydicus, Massariosphaeria, Neomassariosphaeria and Pestalotiopsis montellica.
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| 6. |
- Feitosa, Mary F., et al.
(författare)
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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
- 2018
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Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 13:6
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Tidskriftsartikel (refereegranskat)abstract
- Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
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| 7. |
- Gossas, Thomas, et al.
(författare)
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The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors : characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
- 2013
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Ingår i: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 4:2, s. 432-442
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Tidskriftsartikel (refereegranskat)abstract
- The kinetic characteristics of hydroxamate-based inhibitors of matrix metalloproteinase (MMP)-12 were explored using an SPR biosensor-based assay and enzyme inhibition analysis. These high-affinity inhibitors were shown to dissociate very slowly from the enzyme-inhibitor complex while a carboxylate analogue had a much faster dissociation rate, verifying the importance of the hydroxamate group for the slow dissociation. Progress curve enzyme inhibition analysis confirmed that the hydroxamate compounds but not the carboxylate compound acted as time-dependent inhibitors. The slow dissociation excluded steady-state estimation of IC50-values and K-i values but also made K-i values from progress curve analysis unreliable. Although a full characterization of the inhibitors using biosensor analysis was limited by slow dissociation, it provided kinetic and mechanistic information of relevance for MMP drug discovery and avoided some pitfalls of conventional enzyme inhibition assays.
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| 8. |
- Guo, Jia Wei, et al.
(författare)
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2D Co metal-organic framework nanosheet as an oxidase-like nanozyme for sensitive biomolecule monitoring
- 2023
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Ingår i: Rare Metals. - : Springer Science and Business Media LLC. - 1001-0521 .- 1867-7185. ; 42:3, s. 797-805
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Nanozyme-based biomolecules sensitive and quantitative detection is an attractive strategy due to their high chemical, thermal stability and reactive activity. Here, we have synthesized a significant number of two-dimensional (2D) cobalt-metal-organic framework (Co-MOF) nanosheets with oxidase (OXD)-like activity using a facile solvothermal method in one pot for biomolecule monitoring. The synthesized Co-MOF nanosheets exhibit strong stability, higher specific surface area and more active sites due to their MOF structure. Such Co-MOF nanosheets with excellent OXD-like activity show adequate analytical performance in the quantitative determination of dopamine (DA) and glutathione (GSH) with a wider dynamic sensing range and lower detection limits (DA and GSH: 0.24 and 0.067 μmol·L−1, 3σ/slope, where σ is standard deviation of the blank). This work extends the application of 2D-MOF structures in bioassays and brings new insights into the application of OXD-like nanozymes in bioassays. Graphical abstract: [Figure not available: see fulltext.]
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| 9. |
- Hua, Chen, et al.
(författare)
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Downscaling GCMs using the Smooth Support Vector Machine method to predict daily precipitation in the Hanjiang Basin
- 2010
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Ingår i: Advances in Atmospheric Sciences. - : Springer Science and Business Media LLC. - 0256-1530 .- 1861-9533. ; 27:2, s. 274-284
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Tidskriftsartikel (refereegranskat)abstract
- General circulation models (GCMs) are often used in assessing the impact of climate change at global and continental scales. However, the climatic factors simulated by GCMs are inconsistent at comparatively smaller scales, such as individual river basins. In this study, a statistical downscaling approach based on the Smooth Support Vector Machine (SSVM) method was constructed to predict daily precipitation of the changed climate in the Hanjiang Basin. NCEP/NCAR reanalysis data were used to establish the statistical relationship between the larger scale climate predictors and observed precipitation. The relationship obtained was used to project future precipitation from two GCMs (CGCM2 and HadCM3) for the A2 emission scenario. The results obtained using SSVM were compared with those from an artificial neural network (ANN). The comparisons showed that SSVM is suitable for conducting climate impact studies as a statistical downscaling tool in this region. The temporal trends projected by SSVM based on the A2 emission scenario for CGCM2 and HadCM3 were for rainfall to decrease during the period 2011-2040 in the upper basin and to increase after 2071 in the whole of Hanjiang Basin.
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| 10. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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