| 1. |
- Gustafsson, Harald, et al.
(författare)
-
Den dubbla blicken. En inledning
- 2007
-
Ingår i: Den dubbla blicken. Historia i de nordiska samhällena. - 9789185767007 ; , s. 7-26
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 2. |
- Hommerberg, Charlotte, 1960-
(författare)
-
Hur vi talar om cancer
- 2017
-
Annan publikation (film/video) (populärvet., debatt m.m.)
|
|
| 3. |
- Pena-Perez, Lucia, et al.
(författare)
-
Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
- 2022
-
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 6:17, s. 5009-5023
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy-number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refined detection and reconstruction of SVs by providing long-range genetic information from standard short-read sequencing. This makes lrWGS an attractive solution for capturing the full genomic complexity of MM. Here we show that high-quality lrWGS data can be generated from low numbers of cells subjected to fluorescence-activated cell sorting (FACS) without DNA purification. Using this protocol, we analyzed MM cells after FACS from 37 patients with MM using lrWGS. We found high concordance between lrWGS and fluorescence in situ hybridization (FISH) for the detection of recurrent translocations and CNVs. Outside of the regions investigated by FISH, we identified > 150 additional SVs and CNVs across the cohort. Analysis of the lrWGS data allowed for resolution of the structure of diverse SVs affecting the MYC and t(11;14) loci, causing the duplication of genes and gene regulatory elements. In addition, we identified private SVs causing the dysregulation of genes recurrently involved in translocations with the IGH locus and show that these can alter the molecular classification of MM. Overall, we conclude that lrWGS allows for the detection of aberrations critical for MM prognostics and provides a feasible route for providing comprehensive genetics. Implementing lrWGS could provide more accurate clinical prognostics, facilitate genomic medicine initiatives, and greatly improve the stratification of patients included in clinical trials.
|
|
| 4. |
- Tornbjer, Charlotte, et al.
(författare)
-
Nationalism, kungligheter och genuskonstruktioner i Sverige kring 1905
- 2007
-
Ingår i: Den dubbla blicken. Historia i de nordiska samhällena. - 9789185767007 ; , s. 133-147
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Artiklen tar upp kvinnornas plats i det nationella historiemedvetandet i Sverige kring 1900 och behandlar reltaionen mellan genus och nation i en svensk kontext.
|
|
| 5. |
|
|
| 6. |
- Angelhoff, Charlotte, 1974-, et al.
(författare)
-
Parental mood when staying overnight at hospital with their sick child
- 2015
-
Konferensbidrag (refereegranskat)abstract
- Parental mood when staying overnight at hospital with their sick childObjectiveto describe mood in parents, staying with their sick children overnight at the hospital.MethodologyA descriptive design, including 75 parents staying overnight at hospital with their sick child, was used. The parents filled out Mood-scale the morning after staying overnight at the hospital. The Mood-scale is a validated and reliable self-administered instrument measuring six dimensions of mood; control, calmness, social orientation, pleasantness, activation, and extraversion (Sjöberg L, 1979). The study is a part of a larger project, with focus on mood, stress and sleep in parents staying with their sick children overnight at the hospital.ResultsThe result will describe how parents report their total mood and how they report the different dimensions when they stay with their sick children overnight at the hospital. A comparison will be made between the parent´s mood and gender and the child´s age. Data is under analysis and will be presented as preliminary data. ConclusionAccording to UNICEF Convention on the Rights of the Child, children in hospital have the right to have their parents with them at all times and parents should be offered accommodation and be encouraged to stay. However, the hospital environment, in combination with having a sick child, might affect the parent´s mood, which in turn might affect the ability to handle the situation and the child´s care. Therefore it is of importance to study parental mood and find ways to help the families during their hospital stay.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Angelhoff, Charlotte, 1974-, et al.
(författare)
-
Perceptions of sleep quality and stress by parents of children enrolled in hospital organized home-care
- 2013
-
Ingår i: Nordic Advances in Health Care Sciences Research, Lund, 2013. ; , s. 56-56
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- IntroductionCaring for a sick child creates much greater demands for parents than those associated with raising a healthy child. Parents of chronically ill children reports higher levels of parental stress as a consequence of the substantial social, emotional and personal demands associated with caring. Sleep quality is an important aspect of wellbeing and is strongly related to stress and quality of life. In some Swedish counties families are offered hospital organized home-care for sick children. Caring for a child at home gives the family the opportunity to be together in an environment they know well and where they can feel comfortable and secure. On the other hand it includes several sleep disturbances during the night which affects the ability to handle the situation and support their child. No other study is found about how parents sleep when their child is enrolled in hospital organized home-care. AimTo explore parents’ perceptions of sleep quality and stress when they sleep at home with a child enrolled in hospital organized home-care. MaterialFifteen parents (11 mothers and 4 fathers) with children enrolled in hospital organized home-care from one university hospital and one general hospital in South-eastern Sweden were included. The children ranged in age 0-12 years. MethodParents were interviewed with open-ended questions. Data was analysed with a phenomenographic method according to Marton and Both. ResultsFour descriptive categories in the phenomenon of parents’ perceptions of sleep quality and stress when they sleep at home with a child enrolled in hospital organized home-care were identified; Routines helps to manage the situation, Time for oneself and the partner, Feelings of isolation and Need of support ConclusionSleep is important for the parents in several aspects. They are in a stressful situation with high demands both from the society and from themselves and there is often a lack of support from relatives and friends. Nurses need to acknowledge and promote parents’ sleep when they care for their sick children at home and support them in the caregiving.
|
|
