| 1. |
- Gustafsson, Jennie, 1988-
(författare)
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The state of tenancy : Rental housing and municipal statecraft in Malmö, Sweden
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Rental housing tenants in Sweden and Europe are increasingly seeing their homes subsumed to market pressures. This thesis provides empirical and conceptual insights into the processes by which market and financial practices and logics shape the housing sector, through a critical analysis of rental housing in Malmö, Sweden. The aim of the thesis is to investigate the role of rental housing within the context of municipal governance and, in turn, to explore how the relationship between rental housing and municipal governance affects residents. Empirically, the thesis focuses on developments in and around the area of Rosengård. The methods used include an interpretive analysis of official documents and secondary statistics, interviews, focus group meetings, participant observations, photos, and analysis of register data. The thesis comprises four papers and a comprehensive summary (the “kappa”).Inspired by the regulation approach to political economy, the thesis engages with theoretical literatures on trajectories of rental housing market change, the financialization of rental housing, and local-state restructuring. In demonstrating how tenants and residents are affected by municipalities’ governance of rental markets, the thesis offers fresh perspectives on the nature of contemporary Swedish municipal “statecraft”.The thesis finds that mounting market pressures from the 1980s initially resulted in a relocation of Malmö’s public housing stock to more attractive urban areas, and greater financial independence for the municipal housing company (MKB). In the process, the municipality used its ownership of public housing to support rebranding of the city following deindustrialization. However, more recently, the municipality has integrated management of MKB’s finances into the governance of municipal finances more broadly. The thesis argues that recent examples of public housing privatization and urban renewal have seen the municipal housing stock come to function as a quasi-financial asset, one bearing local urban development-risk and signaling municipal economic flexibility to credit rating analysts. It also argues that residential property investors’ local use of renovations as an investment strategy strengthens their financial position while leading to declining affordability for tenants. Residents experience increasing rent levels, worry, and a lack of influence within – and disclosure of information about – processes of renovation and privatization. Meanwhile, the thesis finds that the spatial distribution of public and private rental housing has changed as a result of municipal governance initiatives to create attractive new urban spaces, with rental tenants being increasingly marginalized. In sum, the thesis concludes that market and financial practices and logics are progressively undermining Sweden’s renowned universal housing system, while reinforcing inequality.
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| 2. |
- Gustafsson, Peter, 1994-
(författare)
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Ships, clouds, and waves : understanding ecosystems in traditional industries
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation builds on a jointly phenomenological and theoretical approach to investigate how traditional industries face challenges related to ecosystem innovation. Phenomenologically, it investigates how innovation within the shipbuilding industry affects the activities performed by firms that have traditionally filled the role of suppliers to shipyards. Innovations in digitalisation threaten to upend long-standing relationships and, as a result, have a substantial impact on the structure of the industry, which has a long history of intense competition, long industry cycles, stable products and services, and dependence on global trade. Theoretically, this dissertation is positioned in the growing literature on ecosystems, which takes a particular interest in how innovation creates new interdependencies between actors, interdependencies that need to be aligned for value to materialise. Through this literature, we have an understanding of how innovation can enable new forms of value to reach end users, how firms can orchestrate such activities, and how new entrants can draw on innovation to threaten established industries. However, we have yet to fully consider how ecosystems emerge and are orchestrated in industries characterised by preexisting interdependencies and latent ecosystem structures and the role of complementors in this process.These issues are examined through four research papers that build on each other to investigate different aspects of the emergence and orchestration of ecosystems in traditional industries. This research follows an abductive approach, meaning that through iteration between data and theory, new results have been generated. The data for the studies are drawn from two case studies within the shipbuilding industry. The papers present four main findings: first, the emergence of ecosystems is significantly impacted by preexisting interdependencies, particularly incentives to innovate and regulatory dependence. Second, these preexisting interdependencies lead to complementors taking a leading role in innovation that spur the emergence of new ecosystems. Third, this is carried out through market and nonmarket strategies as firms must engage with each other and international organisations. Fourth, the preexisting interdependencies also lead to collective orchestration which requires significant internal coordination to successfully perform but allows for market actors to have greater influence in regulatory matters. I arrive at these results by drawing on insights from resource dependence theory, collective action theory, and corporate political activities.
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| 3. |
- Hagström, Peter, 1967-
(författare)
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Biomass Potential for Heat, Electricity and Vehicle Fuel in Sweden
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main objective of this thesis was to determine how far a biomass quantity, equal to the potential produced within the Swedish borders, could cover the present energy needs inSwedenwith respect to economic and ecological circumstances. Three scenarios were studied where the available biomass was converted to heat, electricity and vehicle fuel. Three different amounts of biomass supply were studied for each scenario: 1) potential biomass amounts derived from forestry, non-forest land, forest industry and community; 2) the same amounts as in Case 1, plus the potential biomass amounts derived from agriculture; 3) the same amounts as in Case 1, plus 50% of the potential pulpwood quantity.For evaluating the economic and ecological circumstances of using biomass in the Swedish energy system, the scenarios were complemented with energy, cost and emergy analysis.The scenarios indicated that it may be possible to produce 170.2 PJ (47.3 TWh) per year of electricity from the biomass amounts in Case 2. From the same amount of biomass, the maximum annual production of hydrogen was 241.5 PJ (67.1 TWh) per year or 197.2 PJ (54.8 TWh) per year of methanol.The energy analysis showed that the ratio of energy output to energy input for large-scale applications ranged from 1.9 at electric power generation by gasification of straw to 40 at district heating generation by combustion of recovered wood. The cost of electricity at gasification ranged from 7.95 to 22.58 €/GJ. The cost of vehicle work generated by using hydrogen produced from forestry biomass in novel fuel cells was economically competitive compared to today’s propulsion systems. However, the cost of vehicle work generated by using methanol produced from forestry biomass in combustion engines was rather higher compared to use of petrol in petrol engines.The emergy analysis indicated that the only biomass assortment studied with a larger emergy flow from the local environment, in relation to the emergy flow invested from society after conversion, was fuel wood from non-forest land. However, even use of this biomass assortment for production of heat, electricity or vehicle fuels had smaller yields of emergy output in relation to emergy invested from society compared to alternative conversion processes; thus, the net contribution of emergy generated to the economy was smaller compared to these alternative conversion processes.
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| 4. |
- Senkowski, Wojciech
(författare)
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High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. Monolayer cultures are highly proliferative and generally do not contain quiescent cells, thought to be one of the main reasons for the anticancer therapy failure in clinic. Thus, there is a need for in vitro cellular models that would increase predictive value of preclinical research results. The utilization of more complex three-dimensional (3D) cell cultures, such as multicellular tumor spheroids (MCTS), which contain both proliferating and quiescent cells, has therefore been proposed. However, difficult handling and high costs still pose significant hurdles for application of MCTS for HTS.In this work, we aimed to develop novel assays to apply MCTS for HTS and drug evaluation. We also set out to identify cellular processes that could be targeted to selectively eradicate quiescent cancer cells. In Paper I, we developed a novel MCTS-based HTS assay and found that nutrient-deprived and hypoxic cancer cells are selectively vulnerable to treatment with inhibitors of mitochondrial oxidative phosphorylation (OXPHOS). We also identified nitazoxanide, an FDA-approved anthelmintic agent, to act as an OXPHOS inhibitor and to potentiate the effects of standard chemotherapy in vivo. Subsequently, in Paper II we applied the high-throughput gene-expression profiling method for MCTS-based drug screening. This led to discovery that quiescent cells up-regulate the mevalonate pathway upon OXPHOS inhibition and that the combination of OXPHOS inhibitors and mevalonate pathway inhibitors (statins) results in synergistic toxicity in this cell population. In Paper III, we developed a novel spheroid-based drug combination-screening platform and identified a set of molecules that synergize with nitazoxanide to eradicate quiescent cancer cells. Finally, in Paper IV, we applied our MCTS-based methods to evaluate the effects of phosphodiesterase (PDE) inhibitors in PDE3A-expressing cell lines.In summary, this work illustrates how MCTS-based HTS yields potential to reveal and exploit previously unrecognized tumor-specific vulnerabilities. It also underscores the importance of cell culture conditions in preclinical drug discovery endeavors.
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| 5. |
- Vergoossen, Hellen P., 1988-
(författare)
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Breaking the Binary : Attitudes towards and cognitive effects of gender-neutral pronouns
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- For a long time, Swedish only had two third-person singular pronouns: hon [‘she’] and han [‘he’]. Following several publications using the gender-neutral pronoun hen to refer to its characters, a debate article in a national newspaper proposed expanding the Swedish pronouns with hen. This proposal ignited a nation-wide debate on the use of a gender-neutral pronoun and its potential consequences. Proponents of hen believed that hen would make the language more gender-fair by making gender less salient, and by having a pronoun for nonbinary gender individuals. Opponents believed hen would confuse children and be trivial for achieving gender equality. This response shows that hen challenges beliefs on what language should look like, how gender is defined, and how gender should be represented in language. In this thesis, I have documented beliefs about hen. I have mapped the initial resistance, and found underlying motivations for different types of criticism. In two experimental studies, I tested whether common arguments in the debate are supported by empirical evidence, and whether hen can affect the way others are perceived.Study I documented the content of the criticism of hen. As a background and coding scheme I used research on criticism of past gender-fair language initiatives, such as the replacing of generic ‘he’ with ‘he or she’. I found that the criticism of hen was largely the same as in the 1970s and 1980s. Subsequently, I generated four dimensions of underlying motivations that characterize criticism of gender-fair language. These dimensions of criticisms can be considered and addressed in different ways when implementing and researching gender-fair language.Study II tested whether hen indeed is more distracting in written communication than hon or han. Participants read sentences in which hen referred to role nouns that varied in how strongly they were associated with a gender. The results indicated that hen had a small processing cost compared to hon or han, and there was no difference between lexically gendered or stereotypically gendered role nouns. The common argument that hen is a strong distractor in written communication was thus not supported by these findings. Study III examined how pronouns influence gender categorization and the memory recall of a face. The results indicated that participants were more likely to categorize a gender-ambiguous face as a woman when presented with a feminine pronoun, and that they spent more time looking at feminine faces than masculine faces in the memory task. The opposite was found when the gender-ambiguous face was presented with a masculine pronoun. Encoding a gender-ambiguous face with hen partially eliminated the gender categorization effect. The results show that binary pronouns activate binary gender categorization and that gender-neutral pronouns can reduce such categorization. The findings in this thesis provide insights into the early stages of the implementation of a gender-neutral pronoun, and its potential to affect social cognition. It shows that criticism of hen is fueled by a set of ideological convictions and practical concerns, which it shares with criticism of other gender-fair language initiatives. In addition, hen leads to criticism of breaking the woman-man gender binary. This thesis provides early evidence for the potential of gender-neutral language, such as hen, to reduce biases in social cognition.
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| 6. |
- Williamson, Alice, et al.
(författare)
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
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Tidskriftsartikel (refereegranskat)abstract
- Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
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| 7. |
- Adolfsson, Emelie, 1985-
(författare)
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Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy.The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system towards applications in radiotherapy. The intrinsic efficiency for energies of relevance to brachytherapy and the signal stability were investigated. The dosimetry system was expanded to include a smaller dosimeter model, suitable for measurements in dose gradient regions. An individual sensitivity correction method was applied to the smaller dosimeters to be able to perform dose determinations with the same precision as for the larger ones. EPR dosimetry in general is time consuming and effort was spent to optimize the signal readout procedure regarding measurement time and measurement precision.The system was applied in two clinical applications chosen for their high demands on the dosimetry system: 1) a dosimetry audit for external photon beam therapy and 2) dose verification measurements around a low energy HDR brachytherapy source.The conclusions drawn from this thesis were: dose determinations can be performed with a standard uncertainty of 1.8-2.5% using both the original size dosimeters and the new developed smaller ones. The dosimetry system is robust and useful for applications when high measurement precision and accuracy is prioritized. It is a good candidate for dosimetry audits, both in external beam therapy and brachytherapy.
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| 8. |
- Angelhoff, Charlotte, 1974-
(författare)
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What about the parents? : Sleep quality, mood, saliva cortisol response and sense of coherence in parents with a child admitted to pediatric care
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Parents experience many stressful situations when their child is ill and needs medical care, irrespective of the child’s age, diagnosis or the severity of the illness. Poor sleep quality and negative mood decrease the parents’ ability to sustain attention and focus, to care for their ill child, and to cope with the challenges they face.The overall aim of this thesis was to evaluate sleep, mood, cortisol response, and sense of coherence (SOC) in parents caring for children in need of medical care, and to identify factors that may influence parents’ sleep.This thesis includes four original studies; two of these are quantitative, prospective, descriptive and comparative studies including parents (n=82) accommodated in six pediatric wards with their ill child, using questionnaires and sleep logs to measure sleep, mood and SOC, and saliva cortisol to measure cortisol response. A follow-up was performed four weeks later at home, after hospital discharge. The other two studies are qualitative, inductive and explorative interview studies, including parents (n=12) staying overnight with their preterm and/or ill infant in three neonatal intensive care units, and parents (n=15) with a child receiving hospital-based home care in two pediatric outpatient clinics. The interviews were analyzed with a phenomenographic method.Being together with one’s family seems beneficial for sleep and may decrease stress. The ability to stay with the child, in the hospital or at home, was highly appreciated by the parents. When caring for a child with illness, parents’ sleep quality was sufficient in the hospital; however, sleep quality improved further (p<0.05) at home after discharge. The parents reported frequent nocturnal awakenings in the hospital caused by the child, medical treatment and hospital staff. Concern and anxiety about the child’s health, and uncertainty about the future were stressors affecting the parents’ sleep and mood negatively. The parents had lower (p=0.01) morning awakening cortisol levels in the pediatric ward compared to at home, and parents accommodated for more than one night had lower (p<0.05) post-awakening cortisol levels compared to parents staying their first night.The findings of this thesis conclude that being together as a family is important for the parents’ sleep. The ability to be accommodated in the hospital and gather the family around the child may have given the parents time for relaxation and recovery, that in turn may lead to a less stressful hospital stay. When it is beneficial for the child, the whole family should be included in the pediatric care. Moreover, pediatric nurses must acknowledge parents’ sleep, in hospital and at home. Medical treatment and care at night should be scheduled and sleep promoted for the parents in order to maintain health and well-being in the family.
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| 9. |
- Babu, Prabhu, 1984-
(författare)
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Spectral Analysis of Nonuniformly Sampled Data and Applications
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Signal acquisition, signal reconstruction and analysis of spectrum of the signal are the three most important steps in signal processing and they are found in almost all of the modern day hardware. In most of the signal processing hardware, the signal of interest is sampled at uniform intervals satisfying some conditions like Nyquist rate. However, in some cases the privilege of having uniformly sampled data is lost due to some constraints on the hardware resources. In this thesis an important problem of signal reconstruction and spectral analysis from nonuniformly sampled data is addressed and a variety of methods are presented. The proposed methods are tested via numerical experiments on both artificial and real-life data sets.The thesis starts with a brief review of methods available in the literature for signal reconstruction and spectral analysis from non uniformly sampled data. The methods discussed in the thesis are classified into two broad categories - dense and sparse methods, the classification is based on the kind of spectra for which they are applicable. Under dense spectral methods the main contribution of the thesis is a non-parametric approach named LIMES, which recovers the smooth spectrum from non uniformly sampled data. Apart from recovering the spectrum, LIMES also gives an estimate of the covariance matrix. Under sparse methods the two main contributions are methods named SPICE and LIKES - both of them are user parameter free sparse estimation methods applicable for line spectral estimation. The other important contributions are extensions of SPICE and LIKES to multivariate time series and array processing models, and a solution to the grid selection problem in sparse estimation of spectral-line parameters.The third and final part of the thesis contains applications of the methods discussed in the thesis to the problem of radial velocity data analysis for exoplanet detection. Apart from the exoplanet application, an application based on Sudoku, which is related to sparse parameter estimation, is also discussed.
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| 10. |
- Enghag, Margareta
(författare)
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Two dimensions of student ownership of learning during small-group work with miniprojects and context rich problems in physics
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis the theoretical framework student ownership of learning (SOL) is developed both theoretically and with qualitative research, based on studies of small-group work in physics with miniprojects and context rich problems. Ownership is finally defined as actions of choice and control, i.e. the realised opportunities to own organisation of the work. The dimension group ownership of learning refers to the groups actions of choice and control of the management of the task: how the task is determined, performed and finally reported. The other dimension, the individual student ownership of learning, refers to the individual student's own question/idea that comes from own experiences, interests, or anomalies of understanding; an idea/question that recurs several times and leads to new insights. From literature and from own data, categories are constructed for group and individual student ownership of learning, which have been iteratively sharpened in order to identify ownership in these two dimensions. As a consequence, the use of the framework student ownership of learning is a way to identify an optimal level of ownership for better learning and higher motivation in physics teaching.The first part of the thesis gives an overview of the theoretical background to the studies made, and summarises the findings. The second part consists of six articles that report case studies with analyses of audio/video-recorded student cooperative work, and student group discussions, from three collections of data: 1) students working with miniprojects in teacher education, 2) upper secondary school students taking a physics course that includes both context rich problems with group discussions and miniprojects, and 3), aeronautical engineering students working with context rich problems in an introductory physics course at university.The thesis describes in a fine-grained analysis the conversation in the groups based on Barnes discourse moves, and finds that ownership and communication are related. Group discussions are found to be an indicator for group ownership of learning and exploratory talks often promotes individual student ownership of learning
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