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- Ekman, Maria, et al.
(författare)
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Inte så smakfullt
- 1997
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Ingår i: Dagens Nyheter. ; :27 februari
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 4. |
- Gustafsson, Tony, 1971-
(författare)
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Läkaren, döden och brottet : Studier i den svenska rättsmedicinens etablering
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation investigates the long historical process leading up to the establishment of Swedish forensic medicine in the middle of the 19th century. Both the development of the practice of investigating suspicious deaths, primarily through autopsies, and the scientific development, leading up to the founding of forensic medicine as a medical discipline and a distinct field of knowledge are dealt with. The focus of the study is primarily on the historical process itself, its phases, continuities and discontinuities. The theoretical framework is based on three analytical concepts: medicalization, professionalization and institutionalization. Special attention is also paid to the characteristics of forensic medicine, its position between the law and the medicine, and the consequences this had on its scientific development. The first analytical chapter of the dissertation investigates the oldest medico-legal activities on Swedish ground, with emphasis on the 17th and 18th centuries. In the following chapters the main focus is on the transition period between the older medico-legal activities and the 19th century forensic medicine, an analytical distinction used throughout the dissertation, and the institutionalization of forensic medicine as a teaching subject. The dissertation also includes an historical reconstruction of different aspects of the autopsy practice. Autopsies are viewed as physical operations and a special kind of sign reading, situated between the old semiotic model and the new diagnostic method of the 19th century. In the last chapter the process leading up to the foundation of a distinct forensic field of knowledge in Sweden is studied.
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| 5. |
- Lizárraga, Raquel, et al.
(författare)
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Crystal and magnetic structure investigation of TbNi5-xCux (x=0,0.5,1.0,1.5,2.0) : Experiment and theory
- 2006
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 74:9, s. 094419-
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Tidskriftsartikel (refereegranskat)abstract
- The effect of Cu substitution on the structural and magnetic properties of TbNi5-xCux (x=0,0.5,1.0,1.5,2.0) have been investigated by x-ray diffraction, magnetization measurements and neutron powder and single crystal diffraction. The electronic and the magnetic structures of TbNi5 were studied using first principles theory. All samples were found to have the CaCu5-type structure, space group P6/mmm. The lattice parameters increase monotonically with increasing Cu concentration. The Curie temperature T-c has a maximum value of 29 K at x=1.0. The magnetic structure of TbNi5 at 10 K is incommensurate with a helimagnetic component [wave vector q similar to 2 pi/c(0,0,0.02)] perpendicular to a ferromagnetic one. In contrast, the substituted TbNi5-xCux alloy is ferromagnetic. All magnetic moments are observed to be located on the Tb atoms. The magnetocrystalline anisotropy in the ab plane is observed to be strongly increased by the Cu substitution, whereas the magnetization decreases with the Cu concentration. The observed magnetic structure of TbNi5 is consistent with first principles calculations regarding both the magnetic moments and the helimagnetic structure. The microscopical origin of the helimagnet is analyzed and correlated to the Fermi surface topology.
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| 7. |
- Tyler, Torbjörn, et al.
(författare)
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Skånes mossor.
- 2003
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Ingår i: Floran i Skåne. Vegetation och utflyktsmål.. - 9197102148 ; , s. 117-124
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Bokkapitel (populärvet., debatt m.m.)
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| 8. |
- Aftab, Obaid, 1984-, et al.
(författare)
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NMR spectroscopy based metabolic profiling of drug induced changes in vitro can discriminate between pharmacological classes
- 2014
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Ingår i: Journal of chemical information and modeling. - : American Chemical Society (ACS). - 1549-9596 .- 1549-960X. ; 54:11, s. 3251-3258
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Tidskriftsartikel (refereegranskat)abstract
- Drug induced changes in mammalian cell line models have already been extensively profiled at the systemic mRNA level and subsequently used to suggest mechanisms of action for new substances as well as to support drug repurposing, i.e. identifying new potential indications for drugs already licensed for other pharmacotherapy settings. The seminal work in this field, which includes a large database and computational algorithms for pattern matching, is known as the “Connectivity Map” (CMap). The potential of similar exercises at the metabolite level is, however, still largely unexplored. Only recently the first high throughput metabolomic assay pilot study was published, involving screening of metabolic response to a set of 56 kinase inhibitors in a 96-well format. Here we report results from a separately developed metabolic profiling assay, which leverages 1H NMR spectroscopy to the quantification of metabolic changes in the HCT116 colorectal cancer cell line, in response to each of 26 compounds. These agents are distributed across 12 different pharmacological classes covering a broad spectrum of bioactivity. Differential metabolic profiles, inferred from multivariate spectral analysis of 18 spectral bins, allowed clustering of most tested drugs according to their respective pharmacological class. A more advanced supervised analysis, involving one multivariate scattering matrix per pharmacological class and using only 3 spectral bins (three metabolites), showed even more distinct pharmacology-related cluster formations. In conclusion, this kind of relatively fast and inexpensive profiling seems to provide a promising alternative to that afforded by mRNA expression analysis, which is relatively slow and costly. As also indicated by the present pilot study, the resulting metabolic profiles do not seem to provide as information rich signatures as those obtained using systemic mRNA profiling, but the methodology holds strong promise for significant refinement.
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| 9. |
- Ahmadi, Zainab, et al.
(författare)
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Smoking and home oxygen therapy : a review and consensus statement from a multidisciplinary Swedish taskforce
- 2024
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Ingår i: European Respiratory Review. - : European Respiratory Society. - 0905-9180 .- 1600-0617. ; 33:171
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Forskningsöversikt (refereegranskat)abstract
- Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and policies regarding this matter. This multidisciplinary Swedish taskforce aimed to review the potential benefits and risks of smoking in relation to HOT, including medical, practical, legal and ethical considerations.Methods: The taskforce of the Swedish Respiratory Society comprises 15 members across respiratory medicine, nursing, medical law and ethics. HOT effectiveness and adverse risks related to smoking, as well as practical, legal and ethical considerations, were reviewed, resulting in five general questions and four PICO (population–intervention–comparator–outcome) questions. The strength of each recommendation was rated according to the GRADE (grading of recommendation assessment, development and evaluation) methodology.Results: General questions about the practical, legal and ethical aspects of HOT were discussed and summarised in the document. The PICO questions resulted in recommendations about assessment, management and follow-up of smoking when considering HOT, if HOT should be offered to people that meet the eligibility criteria but who continue to smoke, if a specific length of time of smoking cessation should be considered before assessing eligibility for HOT, and identification of areas for further research.Conclusions: Multiple factors need to be considered in the benefit/risk evaluation of HOT in active smokers. A systematic approach is suggested to guide healthcare professionals in evaluating HOT in relation to smoking.
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