| 1. |
- Dalenbäck, Jan-Olof, 1954, et al.
(författare)
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Ställ tekniska egenskapskrav och använd deklarationerna
- 2014
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Ingår i: Energi & Miljö. - 1101-0568. ; 2014:4, s. 40-41
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Ta bort energikraven i BBR och ersätt dem med ändamålsenliga egenskaps¬krav. Gör sedan energideklarationerna värda namnet genom att inkludera hushålls- och verk¬sam¬hets¬el så att de kan användas för att följa upp energi¬användningen. I anslutning till Boverkets regeringsuppdrag (N2014/75/E) att definiera nya energihus¬håll¬ningskrav, finns det all anledning att diskutera om vi är på rätt väg med de krav på bygg¬naders energi¬prestanda som ställs i Boverkets Byggregler (BBR). Speciellt om dess uppfyllelse ska vara juridiskt bindande.
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| 2. |
- Godoy, Patricio, et al.
(författare)
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
- 2013
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Ingår i: Archives of Toxicology. - : Springer Science and Business Media LLC. - 0340-5761 .- 1432-0738. ; 87:8, s. 1315-1530
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Forskningsöversikt (refereegranskat)abstract
- This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4 alpha, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4 alpha), resulting in up- and downregulation of hundreds of genes. An understanding of these changes is crucial for a correct interpretation of in vitro data. The possibilities and limitations of the most useful liver in vitro systems are summarized, including three-dimensional culture techniques, co-cultures with non-parenchymal cells, hepatospheres, precision cut liver slices and the isolated perfused liver. Also discussed is how closely hepatoma, stem cell and iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, a summary is given of the state of the art of liver in vitro and mathematical modeling systems that are currently used in the pharmaceutical industry with an emphasis on drug metabolism, prediction of clearance, drug interaction, transporter studies and hepatotoxicity. One key message is that despite our enthusiasm for in vitro systems, we must never lose sight of the in vivo situation. Although hepatocytes have been isolated for decades, the hunt for relevant alternative systems has only just begun.
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| 3. |
- Gustavsson, Rudolf, et al.
(författare)
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IDENTITIES IN TRANSITION IN VIKING AGE ALAND?
- 2014
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Ingår i: Viking Age in Aland. - HELSINKI : ACADEMIA SCIENTIARM FINICA. - 9789514110986 - 9514110986 ; , s. 159-186
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Bokkapitel (refereegranskat)
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| 4. |
- Lindehammer, Sabina, et al.
(författare)
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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
- 2008
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Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
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| 5. |
- Sjöberg, Lena
(författare)
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Bäst i klassen? : Lärare och elever i svenska och europeiska policytexter
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis takes its departure in the recent criticism directed to the Swedish school system and its schools, teachers and pupils, but especially the epidemic of policies produced in order to develop and improve Swedish schools, in particular after the change of government in 2006. The general aim of this thesis is to study how teachers and pupils are represented, and thus constructed, regulated and positioned in a number of current key policy texts. The study also involves a discussion of the construction and regulation practices regarding the school, and its role in society. The main context for the study is policy texts and policy practices related to teacher education. Four studies form the cornerstone of the thesis. Through these policy texts different institutional practices are analyzed. These range from European union policy to examination data from a local teacher education institution in Sweden. A main source of inspiration to the theoretical framework of the study has been provided by the work of Michel Foucault. However, in addition to Foucault's constructionist and poststructural basis, theoretical and methodological approaches drawn from Norman Fairclough's critical discourse analysis, Mark Olssen's social-materialist analysis of policy and Stephen J Ball's policy sociology are also included. The first study examines the constructions and governing technologies in four policy texts within the European Union working programme 'Education 2010'. The second study takes a historical perspective in the construction of teachers and pupils, based on teacher education policy text since 1948, and how the ideal teacher, pupil and school are constructed and positioned genealogically. The third study explores the discursive notions of teacher professionalism and how the regulation of teachers operates through this and other discursive practices by the Swedish government and the Teacher union (Lärarförbundet) during two different time periods, 1995-2000 and 2007-2008. The final study examines student teachers' examination assignments, as a local policy practice, and how the student teachers position the ideal pupil and themselves as ideal teachers. It examines how different policy discourses operate in relation to positioning practices. The thesis shows that current neoliberal discourse order in educational policy today is partly challenged by neoconservative rationalities. Secondly, the thesis shows how each teacher and pupil is governed through several discourses, governing technologies and governing techniques, and how these three entities function relationally in the governing of the subject. In common for discourses, governing technologies and techniques are that they are often very 'seductively packaged', which implies that it is almost impossible to resist and oppose them. Finally I claim that the current discourse order, and its discourses, and governing technologies and techniques imply structural inequalities for teachers, but especially between different pupil groups
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| 6. |
- Stockeld, Dag, et al.
(författare)
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A Swedish study of chemoradiation in squamous cell carcinoma of the esophagus
- 2001
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 40, s. 566-
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Tidskriftsartikel (refereegranskat)abstract
- This multicenter study describes the development of a chemoradiation protocol for the treatment of non-metastatic squamous cell carcinoma of the esophagus. Eighty patients were treated with three courses of chemotherapy (cisplatinum and 5-fluorouracil) with concomitant radiotherapy (40 Gy) during the last two courses of chemotherapy. Esophagectomy was performed, when feasible. If no operation was performed, patients were planned to receive a target dose of 64 Gy. Toxicity was mainly attributable to hematological impairment and led to two adjustments of the treatment protocol (addition of filgrastim and lowering of the 5-fluorouracil dose). These changes made it possible to administer the planned treatment in a gradually higher proportion of patients (13/23 [57%] before changes of treatment compared with 30/36 [83%] after changes). Treatment-related mortality was 3.75% (3 patients, associated with leucopenic septicemia after chemotherapy). Fifty-four patients were resected. No per- or postoperative mortality was encountered. The complete response (pathological CR) rate in operated patients was 46% (27/59 patients) after chemoradiation. In the whole series the CR rate (including clinical CR for non-resected patients) was 44%. With a minimum follow-up of 37 months, the 3-year survival for the whole group was 31% compared with 57% for the CR patients. Total 5-year survival thus far (July 1999) is 26%.
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| 7. |
- Sun, Chengjun, et al.
(författare)
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CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
- 2012
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Ingår i: Human Immunology. - : Elsevier. - 0198-8859 .- 1879-1166. ; 73:7, s. 759-766
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.
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| 8. |
- Tebaldini, S., et al.
(författare)
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THE TOMOSENSE EXPERIMENT: MONO- AND BISTATIC SAR TOMOGRAPHY OF FORESTED AREAS AT P-, L-, AND C-BAND
- 2021
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Ingår i: International Geoscience and Remote Sensing Symposium (IGARSS). ; 2021-July, s. 7955-7958
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Konferensbidrag (refereegranskat)abstract
- The TomoSense experiment comprises campaign and research activities in support of future Synthetic Aperture Radar (SAR) mission concepts at P-, L-, and C-band by the European Space Agency (ESA). The research is intended to provide a quantitative basis for the evaluation of single-pass interferometry over temperate forests at L- and C-band and investigate potential synergies between C-band convoy mission concepts and future P- and L-band missions. SAR acquisitions include P- L-, and C-band data acquired at the Eifel National Park in Germany by flying approximately 25 trajectories to provide tomographic imaging capabilities. L- and C-band data were acquired by simultaneously flying two aircraft to gather bistatic data with varying interferometric baselines. Field activities include forest census (dbh, tree height and species) at 80 plots and Terrestrial Laser Scanning (TLS). The dataset is complemented by small-footprint Airborne Lidar Scanning (ALS) and derived products. Preliminary results are here shown relative to polarimetric tomography at P-band and L-band imaging.
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| 9. |
- Tebaldini, S., et al.
(författare)
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TomoSense: A unique 3D dataset over temperate forest combining multi-frequency mono- and bi-static tomographic SAR with terrestrial, UAV and airborne lidar, and in-situ forest census
- 2023
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Ingår i: Remote Sensing of Environment. - : Elsevier BV. - 0034-4257. ; 290
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Tidskriftsartikel (refereegranskat)abstract
- The TomoSense experiment was funded by the European Space Agency (ESA) to support research on remote sensing of forested areas by means of Synthetic Aperture Radar (SAR) data, with a special focus on the use of tomographic SAR (TomoSAR) to retrieve information about the vertical structure of the vegetation at different frequency bands. The illuminated scene is the temperate forest at the Eifel National Park, North-West Germany. Dominant species are beech and spruce trees. Forest height ranges roughly from 10 to 30 m, with peaks up to over 40 m. Forest Above Ground Biomass (AGB) ranges from 20 to 300 Mg/ha, with peaks up to over 400 Mg/ha. SAR data include P-, L-, and C-band surveys acquired by flying up to 30 trajectories in two headings to provide tomographic imaging capabilities. L- and C-band data were acquired by simultaneously flying two aircraft to gather bistatic data along different trajectories. The SAR dataset is complemented by 3D structural canopy measurements made via terrestrial laser scanning (TLS), Unoccupied Aerial Vehicle lidar (UAV-L) and airborne laser scanning (ALS), and in-situ forest census. This unique combination of SAR tomographic and multi-scale lidar data allows for direct comparison of canopy structural metrics across wavelength and scale, including vertical profiles of canopy wood and foliage density, and per-tree and plot-level above ground biomass (AGB). The resulting TomoSense data-set is free and openly available at ESA for any research purpose. The data-set includes ALS-derived maps of forest height and AGB, forest parameters at the level of single trees, TLS raw data, and plot-average TLS vertical profiles. The provided SAR data are coregistered, phase calibrated, and ground steered, to enable a direct implementation of any kind of interferometric or tomographic processing without having to deal with the subtleties of airborne SAR processing. Moreover, the data-base comprises SAR tomographic cubes representing forest scattering in 3D both in Radar and geographical coordinates, intended for use by non-Radar experts. For its unique features and completeness, the TomoSense data-set is intended to serve as an important basis for future research on microwave scattering from forested areas in the context of future Earth Observation missions.
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