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- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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2. |
- Taran, F. A., et al.
(författare)
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Screening and evaluation of potential recipients and donors for living donor uterus transplantation: results from a single-center observational study
- 2019
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282. ; 111:1, s. 186-193
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To report our experience with the screening and selection of potential recipients and living donors of our uterus transplantation (UTx) program. Design: Part of an observational program. Setting: University hospital. Patient(s): Patients with absolute uterine factor infertility (AUFI). Intervention(s): Screening by e-mail and telephone, selection during surgical consultation, and preoperative investigations according to a multistep procedure for living donation. Main Outcome Measure(s): Age, cause of AUFI, exclusion reasons, and preoperative workup. Result(s): A total of 212 potential recipients expressed interest in participation. Among the 46 potential recipients and 49 directed donors were 4 potential recipients, each with 2 directed donors. Mean (range) age of potential recipients was 29.6 (19–41) years. Of the potential recipients, 39 (84.8%) had congenital AUFI and 7 (17.3%) had acquired AUFI. Ultimately, 15 potential recipients with 16 directed donors were selected for participation, with 1 potential recipient having 2 directed donors. Mean age of included potential recipients was 28.9 (22–35) years, and mean donor age was 51.3 (37–62) years. Fourteen potential recipients (93.3%) had congenital AUFI, and one potential recipient (6.7%) had undergone hysterectomy for obstetric complications. Conclusion(s): The number of potential candidates for UTx is not inconsiderable, with congenital AUFI being the leading cause of AUFI in our cohort. However, our findings highlight that large numbers of AUFI patients need to be screened, considering our exclusion rates were >50%, owing to ABO incompatibility, unavailability of a directed donor, and self-withdrawal. Moreover, meticulous preoperative screening, including in-depth psychological assessment, is mandatory to maximize living donor safety and UTx success. © 2018 American Society for Reproductive Medicine
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3. |
- Brucker, S. Y., et al.
(författare)
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Living-Donor Uterus Transplantation: Pre-, Intra-, and Postoperative Parameters Relevant to Surgical Success, Pregnancy, and Obstetrics with Live Births
- 2020
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 9:8
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Tidskriftsartikel (refereegranskat)abstract
- Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS), a congenital disorder characterized by uterovaginal aplasia, but with functional ovaries. Based on our four successful living-donor transplantations and two resulting births, this analysis presents parameters relevant to standardizing recipient/donor selection, UTx surgery, and postoperative treatment, and their implementation in routine settings. We descriptively analyzed prospectively collected observational data from our four uterus recipients, all with MRKHS, their living donors, and the two newborns born to two recipients, including 1-year postnatal follow-ups. Analysis included only living-donor/recipient pairs with completed donor/recipient surgery. Two recipients, both requiring ovarian restimulation under immunosuppression after missed pregnancy loss in one case and no pregnancy in the other, each delivered a healthy boy by cesarean section. We conclude that parameters crucial to successful transplantation, pregnancy, and childbirth include careful selection of donor/recipient pairs, donor organ quality, meticulous surgical technique, a multidisciplinary team approach, and comprehensive follow-up. Surgery duration and blood vessel selection await further optimization, as do the choice and duration of immunosuppression, which are crucial to timing the first embryo transfer. Data need to be collected in an international registry due to the low prevalence of MRKHS.
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5. |
- Merker, L, et al.
(författare)
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Nephropathy for Patients with Diabetes
- 2019
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Ingår i: DIABETOLOGIE UND STOFFWECHSEL. - : Georg Thieme Verlag KG. - 1861-9002 .- 1861-9010. ; 14, s. S235-S239
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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6. |
- Merker, L, et al.
(författare)
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Nephropathy for Patients with Diabetes
- 2021
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Ingår i: DIABETOLOGIE UND STOFFWECHSEL. - : Georg Thieme Verlag KG. - 1861-9002 .- 1861-9010. ; 16, s. S324-S328
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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7. |
- Merker, L, et al.
(författare)
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Nephropathy in diabetes
- 2020
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Ingår i: DIABETOLOGE. - : Springer Science and Business Media LLC. - 1860-9716. ; 16:5, s. 510-514
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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8. |
- Merker, L, et al.
(författare)
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Nephropathy in diabetes
- 2021
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Ingår i: DIABETOLOGE. - : Springer Science and Business Media LLC. - 1860-9716. ; 17:2, s. 175-178
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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9. |
- Merker, L, et al.
(författare)
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Nephropathy in Diabetes
- 2021
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Ingår i: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. - : Georg Thieme Verlag KG. - 1439-3646. ; 129:S 01, s. S60-S63
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Tidskriftsartikel (refereegranskat)
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10. |
- Merker, L, et al.
(författare)
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Nephropathy in diabetes
- 2022
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Ingår i: DIABETOLOGE. - : Springer Science and Business Media LLC. - 1860-9716. ; 18:3, s. 284-288
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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