| 1. |
- Kapoor, Pooja Middha, et al.
(författare)
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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
- 2021
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 113:3, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
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| 2. |
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| 3. |
- Adedeji, Dickson O., et al.
(författare)
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Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients
- 2023
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Ingår i: Brain, Behavior, and Immunity - Health. - : Elsevier BV. - 2666-3546. ; 28
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Tidskriftsartikel (refereegranskat)abstract
- Background: Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases the susceptibility to stress-related health problems. Several dementia and Alzheimer's disease (AD) risk factors have been identified, yet little is known about the role of AL and its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) and cognitive function among memory clinic patients. Hence, this study aims to assess the association between AL and AD biomarkers, cognitive performance, and cognitive decline after 3-years of follow-up.Methods: Data from 188 memory clinic patients were derived from the Cortisol and Stress in AD (Co-STAR) study in Sweden. Participants underwent baseline assessments including blood tests for AL measures (including cortisol, thyroid stimulating hormone, cobalamin, homocysteine, leukocytes, glycated hemoglobin, albumin, high-density and low-density lipoprotein cholesterol, triglycerides, and creatinine), cerebrospinal fluid (CSF) sampling for AD biomarkers and neuropsychological tests including five cognitive domains. Linear regressions were conducted, adjusting for age, sex, and education.Results: Higher AL was associated with lower CSF Aβ1-42 levels (β = −0.175, p = 0.025), reflecting higher brain levels of Aβ1-42. Stratified analyses suggested a significant association among women but not men, although the AL-sex interaction was not statistically significant. AL was not significantly associated with T-tau level (β = −0.030, p = 0.682) and P-tau level (β = 0.091, p = 0.980). There were no significant associations between AL and cognition or cognitive decline after 3 years.Conclusion: This study showed that higher AL was associated with increased brain amyloid accumulation. This suggests that AL may play a role in AD/dementia pathophysiology. Potential sex-related differences should be assessed in further larger studies.
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| 4. |
- Alsanius, Beatrix, et al.
(författare)
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Förundersökning rörande minskat näringsläckage från odlingar med frilandsgrönsaker i Skåne
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Kväve (N) och fosfor (P) är två väsentliga faktorer bakom övergödningsproblematiken. Merparten av de svenska områdena med högt utsläpp av dessa ämnen ligger i södra Östersjön. Områdena kring den skånska kusten har klassats som särskilt känsliga områden. Samtidigt finns det mycket goda förutsättningar i Skåne för odling av kulturer med intensiva produktionsinsatser såsom frilandsgrönsaker. Odling av dessa kulturer förutsätter god tillgänglighet av näringsämnen, särskilt N, samt av vatten. Situationen i dessa kulturer är särskilt känslig i och med att många frilandsgrönsaker skördas i utvecklingsstadier med full tillväxt och då näringsupptaget är som störst. Det finns ett antal redskap för minskning av näringsläckage. Beräkning av växtnäringsbehovet och anpassning av gödslingen är två av dem. För att ytterligare komma tillrätta med problemet finns odlingsåtgärder såsom kvävemur, kalkfilter, reglerad dränering, uppsamling av vatten i dammar samt anläggning av våtmarker. Föreliggande rapport bygger på fallstudier i fem IP-odlingar i Skåne. Vi har utgått ifrån fält i fem pilotföretag med intensiva grönsaksväxtföljder i Skåne. De valda pilotföretagen ligger i vattendistrikten Södra Östersjön och Västerhavet. Pilotytorna varierade i storlek mellan 1 och 25 ha. Vi har analyserat förutsättningar för begränsning av näringsläckaget på pilotytorna ur ett biologiskt-teknologiskt och ekonomiskt perspektiv. I odlarintervjuer sållades möjliga åtgärder fram för begränsning av näringsläckaget på de givna platserna. De av odlarna prioriterade åtgärderna bedömdes sedan också ur ekonomiskt perspektiv. Åtgärder på fältnivå som befanns relevanta att utreda vidare var kalkfilter, kvävemur, våtmark, reglerad dränering, biologisk alvluckring/mullhaltsförbättring samt restaurering av vattendrag med hästskovåtmark samt dammar med fosforavskiljning, rötning av stallgödsel, full Controlled Traffic Farming (CTF) samt bygga en bevattningsdamm. Åtgärder på kulturnivå var bättre behovsanpassning av N och P dels genom förändrade proportioner i NPK-mikro-gödselmedel och dels genom en lärandeprocess med experiment och uppföljning. För de tre företag som inte redan tillämpade radmyllning vid sådd/plantering, till de kulturer där det var möjligt, var detta en relevant åtgärd. Andra åtgärder var bortförsel av skörderester för rötning och In season-CTF, djupluckring efter sättning/plantering, djupluckring vid bäddläggning samt bevattningsramp med slang. Ett försök att skatta effekten av åtgärderna samt beräkna kostnaden per sparat kg näringsämne gjordes på respektive företag. För kvävereduktion fanns viss möjlighet tack vare ungefärliga utlakningsberäkningar gjorda med STANK. Växtnäringsläckaget varierar mycket från fält till fält, från årstid till årstid och från kultur till kultur. Åtgärder i enskilda företag borde bygga på mätningar och kunskap och förutsätter en individuell prövning. De vinster man gör är dels inbesparade gödselmedel, dels miljövinster i form av minskade utsläpp. Dessa besparingar ska sättas i relation till de ökade kostnader som uppkommer
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| 5. |
- Andreasson, Eskil, et al.
(författare)
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Deformation and Damage Mechanisms in Thin Ductile Polymer Films
- 2013
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Konferensbidrag (refereegranskat)abstract
- The mechanical material behavior of highly extensible or ductile polymer films used in the packaging industry has been studied in this work. The polymer material, consisting of different variants of polyethylene grades, is used as several components in the packaging material structure at Tetra Pak®. Experimental tensile tests were used to quantify the mechanical behavior and to be able to calibrate numerical constitutive material models. The studied polymer materials were able to withstand large deformations before breaking, involving both necking in the width and thickness direction of the specimen. During deformation re-orientation of polymer chains and substantial strain-hardening were also occurring. The latter effect was accounted for in the presented material modeling approach. The numerical simulations were solved in the general finite element software Abaqus version 6.13. In this work a continuum damage modeling (CDM) approach was used. CDM which are attractive in macro scale applications, thus solving our engineering problems, was chosen in this study due to the computational efficiency. A damage model consisting of two functionalities; initiation of damage and evolution of damage was suitable for modeling the ductile fracture behavior. During the numerical analysis it has been assumed that the polymer materials are isotropic, homogenous through the thickness, independent of strain rate and independent of temperature to ease the material parameters identification.
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| 6. |
- Berhmann, Gerd, et al.
(författare)
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UPPAAL 4.0
- 2006
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Ingår i: Third International Conference on the Quantitative Evaluation of Systems, QEST 2006. - 0769526659 ; , s. 125-126
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Konferensbidrag (refereegranskat)abstract
- UPPAAL 4.0 is the result of over two and a half years of development and contains many new features, additions to the modeling language, performance improvements, enhancements and polish to the the easy to use graphical user interface, and is accompanied by several open source libraries. The tool and libraries are available free of charge for academic, educational and evaluation purposes from http://www.uppaal.com/. We describe three of the new features: User defined functions, priorities and symmetry reduction.
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| 7. |
- Borel, Cédric, 1979, et al.
(författare)
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Family of Isoreticular Chiral Metal-Organic Frameworks Based on Coordination and Hydrogen Bonds in [M[Co(ethylenediamine)(oxalato)2]2]
- 2010
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 10:4, s. 1971-1978
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Tidskriftsartikel (refereegranskat)abstract
- From the parent compound [Ca[Co(ethylenediamine)(oxalato)2]2]n . 4H2O, 1, a series of framework compounds was prepared via the soluble sodium salt and crystal growth with the divalent metal ions Cd2+, Mn2+, and Sr2+, (2-4). These compounds have the same general formula [M[Co(ethylenediamine)(oxalato)2]2]n . xH2O, and they all form the same four- and eight-connected 3D net having scu topology (and are thus isoreticular) with water filled channels of variable size running in one direction of the crystals. However, they crystallize in two different space groups, the chiral P21) (3, 4, and the low temperature form of 1) and the noncentrosymmetric P-4 (1 and 2). The potential voids upon water removal are 18-20% of the unit cell. Preliminary gas sorption measurements at 298 K and 8 bar show substantial CO2 and N2O uptake (12-14% and 15-16% by mass, respectively), while the H2 uptake was 0.18%, a relatively high value considering the low pressure and high temperature.
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| 8. |
- Carlson, Jan, et al.
(författare)
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SaveCCM: An Analysable Component Model for Real-Time Systems
- 2005
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Ingår i: Proceedings of International Workshop on Formal Aspects of Component Software.
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Konferensbidrag (refereegranskat)abstract
- Component based development is a promising approach for embeddedsystems. Typical for embedded software is the presence of resourceconstraints in multiple dimensions. An essential dimension is time,since many embedded systems have real-time requirements. We define aformal semantics of a component language for embedded systems,SaveCCM, a language designed with vehicle applications and safetyconcerns in focus. The semantics is defined by a transformation intotimed automata with tasks, a formalism that explicitly models timingand real-time task scheduling. A simple SaveCCM system with a PIcontroller is used as a case study. Temporal properties of the PIcontroller have been successfully verified using the timed automatamodel checker Uppaal.
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| 9. |
- Chakraborty, Amrita, et al.
(författare)
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Yeast and fruit fly mutual niche construction and antagonism against mould
- 2022
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Ingår i: Functional Ecology. - : Wiley. - 0269-8463 .- 1365-2435. ; 36:7, s. 1639-1654
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Tidskriftsartikel (refereegranskat)abstract
- A goal in insect–microbe ecology is to understand the mechanisms regulating species associations and mutualistic interactions. The spotted wing drosophila Drosophila suzukii develops in ripening fruit, unlike other drosophilids that typically feed on overripe fruit, and is associated with the yeast Hanseniaspora uvarum. We hypothesized that D. suzukii and H. uvarum engage in niche construction leading to a mutualistic relation, facilitating the exploitation of fruit and berries as larval substrate. We show that H. uvarum proliferates on both ripe and on unripe raspberries, mediates attraction of D. suzukii larvae and adult flies, enhances egg-laying in mated females and is a sufficient food substrate to support larval development. Moreover, H. uvarum suppresses the antagonistic grey mould, Botrytis cinerea in collaboration with D. suzukii larvae, and produces less ethanol than baker's yeast. H. uvarum thus creates favourable conditions for D. suzukii larval development, which is susceptible to ethanol and grey mould. D. suzukii, on the other hand, vectors H. uvarum to suitable substrates such as raspberries, where larval feeding activity enhances growth of H. uvarum. Larval feeding also helps to suppress B. cinerea, which otherwise outcompetes H. uvarum on raspberry, in the absence of fly larvae. In conclusion, H. uvarum enhances D. suzukii larval development on unripe berries, and D. suzukii promotes H. uvarum dispersal and growth on berries. Yeast and fly modify their shared habitat in reciprocal niche construction and mutual interaction. Read the free Plain Language Summary for this article on the Journal blog.
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| 10. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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