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- Dixon-Suen, Suzanne C, et al.
(författare)
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Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study
- 2022
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 56:20, s. 1157-1170
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
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| 3. |
- Håkansson, Peter, et al.
(författare)
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Introduktion: Yrkesutbildningen och den ekonomiska historien
- 2013
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Ingår i: Yrkesutbildningens formering i Sverige 1940-1975. - 9789187351297 ; , s. 9-19
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Yrkesutbildningen har både påverkat och påverkats av den ekonomiska historien och det finns åtminstone två olika teoretiska perspektiv som kan användas. Det ena är det strukturanalytiska perspektivet som utgår från att ekonomin förändras i cykler. En insikt och förståelse som projektet har gett är att yrkesutbildningen inte alltid entydigt följt dessa cykler, och framförallt inte för alla branscher samtidigt. Skogsindustrin, som exempel, påbörjade sin mekanisering mycket senare än många andra branscher i Sverige. Däremot kom behovet av utbildning (i stort sett) att följa branschens mekanisering. Det andra perspektivet är det nyinstitutionella. Detta perspektiv har delvis andra utgångspunkter där utvecklingen av en institution inte alltid motsvaras av vad som tycks mest rationellt. Istället är det uppfattningar, normer, risk och värdesystem som spelar in när institutioner skapas och upprätthålls (North 2005). I detta kapitel presenterar vi dessa teoretiska perspektiv för att undersöka deras relation till yrkesutbildningens formering 1940-1975.
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| 4. |
- Håkansson, Peter, et al.
(författare)
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Ungdomars engagemang i kulturföreningar och socialt kapital
- 2010
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Ingår i: "Mycket mer än bara rock" : musik, ungdom och organisering. - 9789185343133
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Bokkapitel (populärvet., debatt m.m.)abstract
- Ungdomars engagemang i föreningsverksamhet och organisering förutsägs ofta á priori vara något bra. Mer sällan problematiseras frågan, t.ex. genom att ställa frågan vem som organiserar sig. Denna artikel utgår från litteraturen om socialt kapital och har bl.a. tagit intryck av Bourdieus modell för socialt kapital. I en ekonomisk modell med inspiration från Bourdieu kommer värdet av en individs sociala kapital (relationer) att bestämmas av nätverksmedlemmarnas sammanlagda sociala, kulturella och ekonomiska kapital. Detta leder till att det finns ett högre incitament för dem som redan har ett högt sammanlagt kapital att investera i socialt kapital. Artikeln använder sig av data från Ungdomsstyrelsens enkät Lokal uppföljning av ungdomspolitiken (LUPP) för att skatta engagemanget i musikföreningar, givet andra former av kapital.
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| 6. |
- Andersson, Peter, 1981-, et al.
(författare)
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Simulation of the response of a segmented High-Purity Germanium detector for gamma emission tomography of nuclear fuel
- 2020
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Ingår i: SN Applied Sciences. - : Springer. - 2523-3963 .- 2523-3971. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Irradiation testing of nuclear fuel is routinely performed in nuclear test reactors. For qualification and licensing of Accident Tolerant Fuels or Generation IV reactor fuels, an extensive increase in irradiation testing is foreseen in order to fill the gaps of existing validation data, both in normal operational conditions and in order to identify operational limits.Gamma Emission Tomography (GET) has been demonstrated as a viable technique for studies of the behavior of irradiated nuclear fuel, e.g. measurement of fission gas release and inspection of fuel behavior under Loss-Of-Coolant Accident conditions. In this work, the aim is to improve the technique of GET for irradiated nuclear fuel by developing a detector concept for an improved tomography system that allows for a higher spatial resolution and/or faster interrogation.We present the working principles of a novel concept for gamma emission tomography using a segmented High Purity Germanium (HPGe) detector. The performance of this concept was investigated using the Monte Carlo particle transport code MCNP. In particular, the data analysis of the proposed detector was evaluated, and the performance, in terms of full energy efficiency and localization failure rate, has been evaluated.We concluded that the segmented HPGe detector has an advantageous performance as compared to the traditional single-channel detector systems. Due to the scattering nature of gamma rays, a trade-off is presented between efficiency and cross-talk; however, the performance is nevertheless a substantial improvement over the currently used single-channel HPGe detector systems.
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| 9. |
- Bengtsson, Bo, et al.
(författare)
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Residential Mobility and Housing Policy : Continuity and Change in the Swedish Housing Regime
- 2019
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Ingår i: Investigating Spatial Inequalities: Mobility, Housing and Employment in Scandinavia and South-East Europe. - : Emerald Group Publishing Limited. - 9781789739428 ; , s. 139-158
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Bokkapitel (refereegranskat)abstract
- Transaction costs, responsive housing supply, rent controls, tenant protection, and access to credit affect residential mobility these different parts of housing policy are included in what has been defined as housing regimes, which embrace regulations, laws, norms, and ideology as well as economic factors. In this chapter, we investigate how these regimes change by using institutional theories of path dependence. We use Sweden as an example and study three Swedish housing market reforms during the past decades that may have affected residential mobility, each related to one of the main institutional pillars of housing provision: tenure legislation, taxation, and finance. More precisely, we study the development of the rental regulation since the late 1960s, the tax reform in 1991, and the new reforms on mortgages since 2010. What caused these reforms? What were the main mechanisms behind them, and why did they occur at the time they did? We argue, besides affecting residential mobility, these reforms have the common feature of including interesting elements of path dependence and forming critical junctures that have led the development on to a new path. Institutions of tenure legislation, housing finance, and taxation are often claimed to have effects on residential mobility. Although they are seldom designed with the explicit aim of supporting (or counteracting) residential mobility, they may sometimes do so as more or less unintended consequences.
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| 10. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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